Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Alberto Gasco"'
Autor:
Loretta Lazzarato, Elena Gazzano, Marco Blangetti, Aurore Fraix, Federica Sodano, Giulia Maria Picone, Roberta Fruttero, Alberto Gasco, Chiara Riganti, Salvatore Sortino
Publikováno v:
Antioxidants, Vol 8, Iss 11, p 531 (2019)
The engineering of photosensitizers (PS) for photodynamic therapy (PDT) with nitric oxide (NO) photodonors (NOPD) is broadening the horizons for new and yet to be fully explored unconventional anticancer treatment modalities that are entirely control
Externí odkaz:
https://doaj.org/article/b53bd13b3ff34ae5b83f3aaf040f41a9
Publikováno v:
ARKIVOC, Vol 2006, Iss 7, Pp 301-309 (2006)
Externí odkaz:
https://doaj.org/article/895624c0f8bc41d09dcf67d870e4e0d1
Autor:
Elena Reddi, Francesca Spyrakis, Luca Menilli, Salvatore Sortino, Roberta Fruttero, Aurore Fraix, Alberto Gasco, Loretta Lazzarato, Cristina Parisi, Mariacristina Failla, Francesca Moret, Barbara Rolando
Publikováno v:
Chemical Science
The generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) as “unconventional” therapeutics with precise spatiotemporal control by using light stimuli may open entirely new horizons for innovative therapeutic modalities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b14864af30e19c642b9289da269058a
https://pubmed.ncbi.nlm.nih.gov/34163730
https://pubmed.ncbi.nlm.nih.gov/34163730
Autor:
Loretta Lazzarato, Alberto Gasco, Elisabetta Marini, Chiara Riganti, Elena Gazzano, Roberta Fruttero, Barbara Rolando, Federica Sodano
Publikováno v:
Bioorganic chemistry. 111
We herein report a study on a set of hybrid compounds in which 3-R-substituted furoxan moieties (R = CH3, CONH2, CN, SO2C6H5), endowed with varying NO-releasing capacities, are joined to a mitochondrial probe, rhodamine B. Each product has been inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f93606aeee0f55c06e9228f1e9b5dc6
https://pubmed.ncbi.nlm.nih.gov/33901795
https://pubmed.ncbi.nlm.nih.gov/33901795
Autor:
Stefano Guglielmo, Roberta Fruttero, Barbara Rolando, Aurore Fraix, Francesca Spyrakis, Loretta Lazzarato, Cristina Parisi, Alberto Gasco, Salvatore Sortino
A novel molecular hybrid has been designed and synthesized in which acridine orange (AO) is covalently linked to an N-nitrosoaniline derivative through an alkyl spacer. Photoexcitation of the AO antenna with the highly biocompatible green light resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361a8a2f9323bd68a56c133dc7711e04
http://hdl.handle.net/2318/1743323
http://hdl.handle.net/2318/1743323
Autor:
Salvatore Sortino, Alberto Gasco, Aurore Fraix, Roberta Fruttero, Francesca Spyrakis, Cristina Parisi, Konstantin Chegaev, Loretta Lazzarato, Mariacristina Failla
We report for the first time a NO photodonor (NOPD) operating with the widely used chemotherapeutic agent doxorubicin (DOX) as the light-harvesting antenna. This permits NO uncaging from an N-nitroso appendage upon selective excitation of DOX with hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5decae15d51621a99de36f4485ccc54
http://hdl.handle.net/2318/1743030
http://hdl.handle.net/2318/1743030
Autor:
Barbara Rolando, Marilù Fanelli, Ilaria Buondonno, Elisa Tavanti, Alberto Gasco, Konstantin Chegaev, Massimo Serra, Chiara Riganti, Claudia Maria Hattinger, Elena Gazzano, Joanna Kopecka, Roberta Fruttero
Publikováno v:
Cellular and Molecular Life Sciences. 76:609-625
Doxorubicin is one of the most effective drugs for the first-line treatment of high-grade osteosarcoma. Several studies have demonstrated that the major cause for doxorubicin resistance in osteosarcoma is the increased expression of the drug efflux t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4057abb1931dca5c51981d630a43c70
https://doi.org/10.1007/s00018-018-2967-9
https://doi.org/10.1007/s00018-018-2967-9
Autor:
Konstantin Chegaev, Roberta Fruttero, Joanna Kopecka, Barbara Rolando, Massimo Valoti, Barbara Stella, Mara Brancaccio, Iris Chiara Salaroglio, Silvia Arpicco, Isabella Pedrini, Simona Saponara, Elena Gazzano, Matteo Sorge, Chiara Riganti, Ilaria Buondonno, Alberto Gasco, Alessandro Marengo
Publikováno v:
Journal of Controlled Release. 270:37-52
Drug efflux transporters, in particular P-glycoprotein (Pgp), limit the success of chemotherapy. We previously found that synthetic doxorubicin conjugated with nitric oxide (NO)-releasing group overcomes resistance by inducing a NO-mediated inhibitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::685daf9eaf8698ab1836229104cdb476
https://doi.org/10.1016/j.jconrel.2017.11.042
https://doi.org/10.1016/j.jconrel.2017.11.042
Autor:
Roberta Fruttero, Elena Gazzano, Salvatore Sortino, Aurore Fraix, Federica Sodano, Marco Blangetti, Chiara Riganti, Alberto Gasco, Giulia Maria Picone, Loretta Lazzarato
Publikováno v:
Antioxidants
Volume 8
Issue 11
Antioxidants, Vol 8, Iss 11, p 531 (2019)
Volume 8
Issue 11
Antioxidants, Vol 8, Iss 11, p 531 (2019)
The engineering of photosensitizers (PS) for photodynamic therapy (PDT) with nitric oxide (NO) photodonors (NOPD) is broadening the horizons for new and yet to be fully explored unconventional anticancer treatment modalities that are entirely control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b78c476d9471e44e41e34553b72c12e9
http://europepmc.org/articles/PMC6912809
http://europepmc.org/articles/PMC6912809
Autor:
Mariacristina Failla, Elena Gazzano, Cristina Parisi, Francesca Spyrakis, Alberto Gasco, Barbara Rolando, Chiara Riganti, Aurore Fraix, Salvatore Sortino, Eleonora Gianquinto, Loretta Lazzarato, Roberta Fruttero
Two novel NO photodonors (NOPDs) based on BODIPY and Rhodamine antennae activatable with the highly biocompatible green light are reported. Both NOPDs exhibit considerable fluorescence emission and release NO with remarkable quantum efficiencies. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeffe9947389172109951a6f2dad207d
http://hdl.handle.net/2318/1712387
http://hdl.handle.net/2318/1712387