Zobrazeno 1 - 10
of 370
pro vyhledávání: '"Alberto, Villanueva"'
Autor:
Marie-Julie Nokin, Alessia Mira, Enrico Patrucco, Biagio Ricciuti, Sophie Cousin, Isabelle Soubeyran, Sonia San José, Serena Peirone, Livia Caizzi, Sandra Vietti Michelina, Aurelien Bourdon, Xinan Wang, Daniel Alvarez-Villanueva, María Martínez-Iniesta, August Vidal, Telmo Rodrigues, Carmen García-Macías, Mark M. Awad, Ernest Nadal, Alberto Villanueva, Antoine Italiano, Matteo Cereda, David Santamaría, Chiara Ambrogio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Selective KRASG12C inhibitors have been developed to covalently lock the oncogene in the inactive GDP-bound state. Two of these molecules, sotorasib and adagrasib, are approved for the treatment of adult patients with KRASG12C-mutated previo
Externí odkaz:
https://doaj.org/article/720b0c9c9a024f38961f97cf298e776d
Autor:
Edgar Creus‐Bachiller, Juana Fernández‐Rodríguez, Miriam Magallón‐Lorenz, Sara Ortega‐Bertran, Susana Navas‐Rutete, Cleofe Romagosa, Tulio M. Silva, Maria Pané, Anna Estival, Diana Perez Sidelnikova, Mireia Morell, Helena Mazuelas, Meritxell Carrió, Tereza Lausová, David Reuss, Bernat Gel, Alberto Villanueva, Eduard Serra, Conxi Lázaro
Publikováno v:
Molecular Oncology, Vol 18, Iss 4, Pp 895-917 (2024)
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft‐tissue sarcomas with a poor survival rate, presenting either sporadically or in the context of neurofibromatosis type 1 (NF1). The histological diagnosis of MPNSTs can be challen
Externí odkaz:
https://doaj.org/article/7781165f8bd2471e855029a3e508c066
Autor:
Valentina Tonelotto, Marcel Costa-Garcia, Eve O’Reilly, Kaelin Francis Smith, Kayleigh Slater, Eugene T. Dillon, Marzia Pendino, Catherine Higgins, Paola Sist, Rosa Bosch, Sabina Passamonti, Josep M. Piulats, Alberto Villanueva, Federica Tramer, Luca Vanella, Michelle Carey, Breandán N. Kennedy
Publikováno v:
Cell Death Discovery, Vol 10, Iss 1, Pp 1-18 (2024)
Abstract Uveal melanoma (UM) is an ocular cancer, with propensity for lethal liver metastases. When metastatic UM (MUM) occurs, as few as 8% of patients survive beyond two years. Efficacious treatments for MUM are urgently needed. 1,4-dihydroxy quini
Externí odkaz:
https://doaj.org/article/a9bd8fb17964483389a107365ee28f49
Autor:
Maria Eugénia Marques Da Costa, Sakina Zaidi, Jean-Yves Scoazec, Robin Droit, Wan Ching Lim, Antonin Marchais, Jerome Salmon, Sarah Cherkaoui, Raphael J. Morscher, Anouchka Laurent, Sébastien Malinge, Thomas Mercher, Séverine Tabone-Eglinger, Isabelle Goddard, Francoise Pflumio, Julien Calvo, Francoise Redini, Natacha Entz-Werlé, Aroa Soriano, Alberto Villanueva, Stefano Cairo, Pascal Chastagner, Massimo Moro, Cormac Owens, Michela Casanova, Raquel Hladun-Alvaro, Pablo Berlanga, Estelle Daudigeos-Dubus, Philippe Dessen, Laurence Zitvogel, Ludovic Lacroix, Gaelle Pierron, Olivier Delattre, Gudrun Schleiermacher, Didier Surdez, Birgit Geoerger
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-15 (2023)
Abstract Pediatric patients with recurrent and refractory cancers are in most need for new treatments. This study developed patient-derived-xenograft (PDX) models within the European MAPPYACTS cancer precision medicine trial (NCT02613962). To date, 1
Externí odkaz:
https://doaj.org/article/0bccef955fcd4460a5c66a0d211aaac0
Autor:
Eva Quandt, Núria Masip, Sara Hernández‐Ortega, Abril Sánchez‐Botet, Laura Gasa, Ainhoa Fernández‐Elorduy, Sara Plutta, Joan Marc Martínez‐Láinez, Samuel Bru, Pau M. Munoz‐Torres, Martin Floor, Jordi Villà‐Freixa, May C. Morris, August Vidal, Alberto Villanueva, Josep Clotet, Mariana P. C. Ribeiro
Publikováno v:
Molecular Oncology, Vol 17, Iss 7, Pp 1228-1245 (2023)
Cyclin‐dependent kinases (CDKs), together with their cyclin partners, are the master cell cycle regulators. Remarkably, the cyclin family was extended to include atypical cyclins, characterized by distinctive structural features, but their partner
Externí odkaz:
https://doaj.org/article/4d91340f06a24d8eb0bf9f70674462b3
Autor:
Vanessa Ortiz-Barahona, Marta Soler, Veronica Davalos, Carlos A. García-Prieto, Maxime Janin, Fernando Setien, Irene Fernández-Rebollo, Joan J. Bech-Serra, Carolina De La Torre, Sonia Guil, Alberto Villanueva, Pei-Hong Zhang, Li Yang, Marco Guarnacci, Ulrike Schumann, Thomas Preiss, Ugne Balaseviciute, Robert Montal, Josep M. Llovet, Manel Esteller
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-15 (2023)
Abstract Background RNA modifications are important regulators of transcript activity and an increasingly emerging body of data suggests that the epitranscriptome and its associated enzymes are altered in human tumors. Methods Combining data mining a
Externí odkaz:
https://doaj.org/article/b94a70a8367746bebebcde0b3709b994
Autor:
Anthony Edey, Neal Navani, Andrew W Creamer, Kitty Chan, Graham Robinson, Janine Zylstra, Paul Robinson, Laura Green, Anand Devaraj, Jane Rowlands, Allan Hackshaw, Carolyn Horst, Arjun Nair, Sam M Janes, Kate Davies, Jeannie Eng, Mamta Ruparel, Samantha L Quaife, Jennifer L Dickson, Magali Taylor, Angshu Bhowmik, Karen Sennett, Samantha Quaife, Samuel Janes, Hasti Robbie, Joseph Jacob, Laura Farrelly, Sophie Tisi, Andrew Creamer, Helen Hall, Samanjit Hare, Jon Teague, Thea Buchan, Stephen Ellis, Thomas Callender, Rachael Sarpong, John McCabe, Zaheer Mangera, Ethaar El-Emir, Terry O'Shaughnessy, Nick Screaton, Priyam Verghese, William M Ricketts, Anne-Marie Mullin, Vicky Bowyer, Kylie Gyertson, Fanta Bojang, Claire Levermore, Ruth Prendecki, Amyn Bhamani, Malavika Suresh, Judy Airebamen, Alice Cotton, Kaylene Phua, Elodie Murali, Simranjit Mehta, Karen Parry-Billings, Columbus Ife, April Neville, Zahra Hanif, Helen Kiconco, Ricardo McEwen, Dominique Arancon, Nicholas Beech, Derya Ovayolu, Christine Hosein, Sylvia Patricia Enes, Qin April Neville, Aashna Samson, Urja Patel, Fahmida Hoque, Hina Pervez, Sofia Nnorom, Moksud Miah, Julian McKee, Mark Clark, Anant Patel, Sara Lock, Rajesh Banka, Ugo Ekeowa, Charlotte Cash, Tunku Aziz, Alberto Villanueva, Elena Stefan, Charlie Sayer, Navinah Nundlall, Lyndsey Gallagher, Andrew Crossingham, Tanita Limani, Kate Gowers, James Rusius, Jennifer Dickson, Anne-Marie Hacker, Jonathon Teague, Andrew Perugia TaniaAnastasiadis
Publikováno v:
BMJ Open Respiratory Research, Vol 10, Iss 1 (2023)
Background Pulmonary and extrapulmonary incidental findings are frequently identified on CT scans performed for lung cancer screening. Uncertainty regarding their clinical significance and how and when such findings should be reported back to clinici
Externí odkaz:
https://doaj.org/article/692746dcaaef4d76b3535374a9068d7e
Autor:
Isabel C. Lopez‐Mejia, Jordi Pijuan, Raúl Navaridas, Maria Santacana, Sònia Gatius, Ana Velasco, Gerard Castellà, Anaïs Panosa, Elisa Cabiscol, Miquel Pinyol, Laura Coll, Núria Bonifaci, Laura Plata Peña, August Vidal, Alberto Villanueva, Eloi Gari, David Llobet‐Navàs, Lluis Fajas, Xavier Matias‐Guiu, Andrée Yeramian
Publikováno v:
Molecular Oncology, Vol 17, Iss 1, Pp 98-118 (2023)
Uterine serous carcinoma (USC) is an aggressive form of endometrial cancer (EC), characterized by its high propensity for metastases. In fact, while endometrioid endometrial carcinoma (EEC), which accounts for 85% of EC, presents a good prognosis, US
Externí odkaz:
https://doaj.org/article/f663469d36c74406919fb1ffb516ab40
Autor:
Helena Mazuelas, Itziar Uriarte-Arrazola, Juana Fernández-Rodríguez, Miriam Magallón-Lorenz, Alberto Villanueva, Conxi Lázaro, Bernat Gel, Eduard Serra, Meritxell Carrió
Publikováno v:
STAR Protocols, Vol 4, Iss 2, Pp 102198- (2023)
Summary: Neurofibromas are benign peripheral nervous system tumors associated with neurofibromatosis type 1, which originate from NF1(−/−) Schwann cell precursors. We describe a protocol to generate neurofibromaspheres by differentiating NF1(−/
Externí odkaz:
https://doaj.org/article/00a95e5266fc439d86b484a9ead626ee
Autor:
Laura Solé, Teresa Lobo-Jarne, Daniel Álvarez-Villanueva, Josune Alonso-Marañón, Yolanda Guillén, Marta Guix, Irene Sangrador, Catalina Rozalén, Anna Vert, Antonio Barbachano, Joan Lop, Marta Salido, Beatriz Bellosillo, Raquel García-Romero, Marta Garrido, Jessica González, María Martínez-Iniesta, Erika López-Arribillaga, Ramón Salazar, Clara Montagut, Ferrán Torres, Mar Iglesias, Toni Celià-Terrassa, Alberto Muñoz, Alberto Villanueva, Anna Bigas, Lluís Espinosa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The failure of chemotherapy in colorectal cancer is currently unclear. Here, the authors show that upon sub-lethal dose of chemotherapy wild-type p53 colorectal cancers acquire a quiescence-like phenotype and a YAP-dependent fetal-like intestinal ste
Externí odkaz:
https://doaj.org/article/a95e4335e7804b569fac9baa390c372b