Growth and differentiation of human induced pluripotent stem cell (hiPSC)-derived kidney organoids using fully synthetic peptide hydrogels

Autor: Niall J. Treacy, Shane Clerkin, Jessica L. Davis, Ciarán Kennedy, Aline F. Miller, Alberto Saiani, Jacek K. Wychowaniec, Dermot F. Brougham, John Crean

Publikováno v: Bioactive Materials, Vol 21, Iss , Pp 142-156 (2023)

Human induced pluripotent stem cell (hiPSC)-derived kidney organoids have prospective applications ranging from basic disease modelling to personalised medicine. However, there remains a necessity to refine the biophysical and biochemical parameters

Externí odkaz: https://doaj.org/article/e2d13a4d716e47b4b691e887cb4c6098

Thermal, Mechanical, and Morphological Characterisations of Graphene Nanoplatelet/Graphene Oxide/High-Hard-Segment Polyurethane Nanocomposite: A Comparative Study

Autor: Muayad Albozahid, Haneen Zuhair Naji, Zoalfokkar Kareem Alobad, Jacek K. Wychowaniec, Alberto Saiani

Publikováno v: Polymers, Vol 14, Iss 19, p 4224 (2022)

The current work investigates the effect of the addition of graphene nanoplatelets (GNPs) and graphene oxide (GO) to high hard-segment polyurethane (75% HS) on its thermal, morphological, and mechanical properties. Polyurethane (PU) and its nanocompo

Externí odkaz: https://doaj.org/article/5824a8d3ab744a04bed9a8c713c6cb74

Self-Assembling Peptide Hydrogels as Functional Tools to Tackle Intervertebral Disc Degeneration

Autor: Cosimo Ligorio, Judith A. Hoyland, Alberto Saiani

Publikováno v: Gels, Vol 8, Iss 4, p 211 (2022)

Low back pain (LBP), caused by intervertebral disc (IVD) degeneration, is a major contributor to global disability. In its healthy state, the IVD is a tough and well-hydrated tissue, able to act as a shock absorber along the spine. During degeneratio

Externí odkaz: https://doaj.org/article/35b8263394b94457bfb7c66770472c92

Effect of the Molecular Structure of TPU on the Cellular Structure of Nanocellular Polymers Based on PMMA/TPU Blends

Autor: Ismael Sánchez-Calderón, Victoria Bernardo, Mercedes Santiago-Calvo, Haneen Naji, Alberto Saiani, Miguel Ángel Rodríguez-Pérez

Publikováno v: Polymers, Vol 13, Iss 18, p 3055 (2021)

In this work, the effects of thermoplastic polyurethane (TPU) chemistry and concentration on the cellular structure of nanocellular polymers based on poly(methyl-methacrylate) (PMMA) are presented. Three grades of TPU with different fractions of hard

Externí odkaz: https://doaj.org/article/a2ec749bf8b745e8b8c872afb9559cf0

Acidic and basic self-assembling peptide and peptide-graphene oxide hydrogels: characterisation and effect on encapsulated nucleus pulposus cells

Autor: Cosimo Ligorio, Aravind Vijayaraghavan, Judith A. Hoyland, Alberto Saiani

Publikováno v: Ligorio, C, Vijayaraghavan, A, Hoyland, J & Saiani, A 2022, ' Acidic and Basic Self-Assembling Peptide and Peptide-Graphene Oxide Hydrogels: Characterisation and Effect on Encapsulated Nucleus Pulposus Cells ', Acta Biomaterialia, vol. 143, pp. 145-158 . https://doi.org/10.1016/j.actbio.2022.02.022

Extracellular pH can have a profound effect on cell metabolism, gene and protein expression. Nucleus pulposus (NP) cells, for example, under acidic conditions accelerate the production of degradative enzymes and pro-inflammatory cytokines, leading ul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6193037f320bb6c25e8b6b4ab7409d01
https://doi.org/10.1016/j.actbio.2022.02.022