Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Alberto, Pappo"'
Publikováno v:
EJC Paediatric Oncology, Vol 2, Iss , Pp 100117- (2023)
Background: Immune checkpoint inhibitors (ICIs) are used to treat many adult cancers and are now being used to treat select pediatric cancers. Many toxicities resulting from ICIs, also known as immune-related adverse events (IRAEs), have been reporte
Externí odkaz:
https://doaj.org/article/7ce768dedfe54f4cb9a722a1c53e3e21
Autor:
James C. H. Yang, Marcia S. Brose, Gilberto Castro, Edward S. Kim, Ulrik N. Lassen, Serge Leyvraz, Alberto Pappo, Fernando López-Ríos, John A. Reeves, Marc Fellous, Frédérique Penault-Llorca, Erin R. Rudzinski, Ghazaleh Tabatabai, Gilles Vassal, Alexander Drilon, Jonathan Trent
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)
Abstract Background Tropomyosin receptor kinase (TRK) fusion proteins resulting from neurotrophic tyrosine receptor kinase (NTRK) gene fusions are rare primary oncogenic drivers in a wide array of tumors. Larotrectinib is a first-in-class, highly sel
Externí odkaz:
https://doaj.org/article/d03b60bd6de0450a90283154c262afe5
Autor:
Maged Zeineldin, Sara Federico, Xiang Chen, Yiping Fan, Beisi Xu, Elizabeth Stewart, Xin Zhou, Jongrye Jeon, Lyra Griffiths, Rosa Nguyen, Jackie Norrie, John Easton, Heather Mulder, Donald Yergeau, Yanling Liu, Jianrong Wu, Collin Van Ryn, Arlene Naranjo, Michael D. Hogarty, Marcin M. Kamiński, Marc Valentine, Shondra M. Pruett-Miller, Alberto Pappo, Jinghui Zhang, Michael R. Clay, Armita Bahrami, Peter Vogel, Seungjae Lee, Anang Shelat, Jay F. Sarthy, Michael P. Meers, Rani E. George, Elaine R. Mardis, Richard K. Wilson, Steven Henikoff, James R. Downing, Michael A. Dyer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible.
Externí odkaz:
https://doaj.org/article/08a87c1bf95d4f798e9e0d5a7daabd61
Autor:
Jared S. Rosenblum, Herui Wang, Pauline M. Dmitriev, Anthony J. Cappadona, Panagiotis Mastorakos, Chen Xu, Abhishek Jha, Nancy Edwards, Danielle R. Donahue, Jeeva Munasinghe, Matthew A. Nazari, Russell H. Knutsen, Bruce R. Rosenblum, James G. Smirniotopoulos, Alberto Pappo, Robert F. Spetzler, Alexander Vortmeyer, Mark R. Gilbert, Dorian B. McGavern, Emily Chew, Beth A. Kozel, John D. Heiss, Zhengping Zhuang, Karel Pacak
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Mutations in EPAS1, encoding hypoxia-inducible factor-2α (HIF-2α), were previously identified in a syndrome of multiple paragangliomas, somatostatinoma, and polycythemia. HIF-2α, when dimerized with HIF-1β, acts as an angiogenic transcription fac
Externí odkaz:
https://doaj.org/article/13982532d1b84ab7917970578fa07532
Autor:
Andrew DJ. Pearson, Carl Allen, Jason Fangusaro, Caroline Hutter, Olaf Witt, Susan Weiner, Gregory Reaman, Mark Russo, Pratiti Bandopadhayay, Sama Ahsan, Amy Barone, Elly Barry, Teresa de Rojas, Michael Fisher, Elizabeth Fox, Julia Glade Bender, Lia Gore, Darren Hargrave, Doug Hawkins, Brent Kreider, Abraham J. Langseth, Giovanni Lesa, Franca Ligas, Marcelo Marotti, Lynley V. Marshall, Kahina Nasri, Koen Norga, Karsten Nysom, Alberto Pappo, Gianluca Rossato, Nicole Scobie, Malcolm Smith, Elliot Stieglitz, Brenda Weigel, Amy Weinstein, Ruth Viana, Dominik Karres, Gilles Vassal
Publikováno v:
European Journal of Cancer. 177:120-142
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e51cb81f4e064a01a1e1d2c5bc7d4f56
https://doi.org/10.1016/j.ejca.2022.09.036
https://doi.org/10.1016/j.ejca.2022.09.036
Autor:
Jessica Gartrell, Alberto Pappo
Publikováno v:
F1000Research, Vol 9 (2020)
Rhabdomyosarcoma (RMS) is a high-grade malignant neoplasm, with a morphologic appearance mimicking that of developing skeletal muscle. Over the last 30 years, patient outcomes have improved with the incorporation of multimodal therapies, including ch
Externí odkaz:
https://doaj.org/article/b403a924b2424b598eea9d0185076418
Autor:
Tanja A. Gruber, Jinghui Zhang, Chunliang Li, Alberto Pappo, Joy Nakitandwe, Susana Raimondi, Teresa Santiago, Vasiliki Leventaki, Gang Wu, Yang Zhang, Jing Ma, Sarah Aldridge, Alyssa N. Obermayer, Amelia M.R. Smith, Kohei Hagiwara, Scott Newman, Alexander M. Gout, Timothy I. Shaw, Jinjun Dang, Jennifer L. Kamens
Supplementary Methods and FiguresSupplementary Figure 1. A newborn with isolated myeloid sarcoma.Supplementary Figure 2. Myeloid Sarcoma Histology.Supplementary Figure 3. Bone Marrow.Supplementary Figure 4. Genes Upregulated in CIC-NUTM2A.Supplementa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23670cd213589435a04c8fc64695de62
https://doi.org/10.1158/1541-7786.22495345.v1
https://doi.org/10.1158/1541-7786.22495345.v1
Autor:
Tanja A. Gruber, Jinghui Zhang, Chunliang Li, Alberto Pappo, Joy Nakitandwe, Susana Raimondi, Teresa Santiago, Vasiliki Leventaki, Gang Wu, Yang Zhang, Jing Ma, Sarah Aldridge, Alyssa N. Obermayer, Amelia M.R. Smith, Kohei Hagiwara, Scott Newman, Alexander M. Gout, Timothy I. Shaw, Jinjun Dang, Jennifer L. Kamens
Myeloid sarcoma is a rare condition consisting of extramedullary myeloid blasts found in association with acute myeloid leukemia or, in the absence of bone marrow involvement. We identified an infant with isolated myeloid sarcoma whose bone marrow wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc64f8f2492e4398d6986bb804922672
https://doi.org/10.1158/1541-7786.c.6534832.v1
https://doi.org/10.1158/1541-7786.c.6534832.v1
Autor:
Tanja A. Gruber, Jinghui Zhang, Chunliang Li, Alberto Pappo, Joy Nakitandwe, Susana Raimondi, Teresa Santiago, Vasiliki Leventaki, Gang Wu, Yang Zhang, Jing Ma, Sarah Aldridge, Alyssa N. Obermayer, Amelia M.R. Smith, Kohei Hagiwara, Scott Newman, Alexander M. Gout, Timothy I. Shaw, Jinjun Dang, Jennifer L. Kamens
Supplementary Table 1. Validated Tier 1-3 Mutation CallsSupplementary Table 2. Genes Upregulated in CIC-NUTM2ASupplementary Table 3. CIC-NUTM2A Gene Set Enrichment Analysis in Pediatric Hematologic MalignanciesSupplementary Table 4. ssGSEA for Top Sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f132a3df9d78380038efd4c3b320cb
https://doi.org/10.1158/1541-7786.22495342
https://doi.org/10.1158/1541-7786.22495342
Autor:
Teresa Rojas, Andrew J. Pearson, Nicole Scobie, Leona Knox, Darshan Wariabharaj, Pamela Kearns, Gilles Vassal, Gregory Reaman, Todd Alonzo, Andrea Biondi, Kathy Brodeur‐Robb, Maryam Fouladi, Thomas Gross, Stephen Hunger, Geoff McCowage, Alberto Pappo, Martin Schrappe, Maria Grazia Valsecchi, Brenda Weigel, Peter Wejbora, James Whitlock, Michel Zwaan, Vickie Buenger, Donna Ludwinski, Elly Barry, Kathleen Neville, Anjali Sharma, Dominik Karres
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 10, Iss 23, Pp 8462-8474 (2021)
Cancer Medicine, Vol 10, Iss 23, Pp 8462-8474 (2021)
Background Since pediatric cancer drug development is a global enterprise, we sought to provide an overview of the landscape of intercontinental clinical trials in pediatric oncology opened over the last decade. Methods ClinicalTrials.gov was systema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f0b97eded30450b8df1e28242a214ca
https://doi.org/10.1002/cam4.4356
https://doi.org/10.1002/cam4.4356