Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Alberto, Malerba"'
Autor:
Alexis Boulinguiez, Jamila Dhiab, Barbara Crisol, Laura Muraine, Ludovic Gaut, Corentin Rouxel, Justine Flaire, Hadidja‐Rose Mouigni, Mégane Lemaitre, Benoit Giroux, Lucie Audoux, Benjamin SaintPierre, Arnaud Ferry, Vincent Mouly, Gillian Butler‐Browne, Elisa Negroni, Alberto Malerba, Capucine Trollet
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 1976-1988 (2024)
Abstract Background Exercise is widely considered to have beneficial impact on skeletal muscle aging. In addition, there are also several studies demonstrating a positive effect of exercise on muscular dystrophies. Oculopharyngeal muscular dystrophy
Externí odkaz:
https://doaj.org/article/9e6f075692794eb9b63cdf6993ff5f94
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 13, p 6994 (2024)
Aberrant expression of the double homeobox 4 (DUX4) gene in skeletal muscle predominantly drives the pathogenesis of facioscapulohumeral muscular dystrophy (FSHD). We recently demonstrated that berberine, an herbal extract known for its ability to st
Externí odkaz:
https://doaj.org/article/8749c0e0aece4567af6bee0137a0ced0
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6113 (2024)
Periostin, a multifunctional 90 kDa protein, plays a pivotal role in the pathogenesis of fibrosis across various tissues, including skeletal muscle. It operates within the transforming growth factor beta 1 (Tgf-β1) signalling pathway and is upregula
Externí odkaz:
https://doaj.org/article/e19bfd2bc8d6464394b032da00f30953
Autor:
Jessica Trundle, Viktorija Cernisova, Alexis Boulinguiez, Ngoc Lu-Nguyen, Alberto Malerba, Linda Popplewell
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 216 (2024)
Duchenne muscular dystrophy (DMD) is characterised by fibrotic tissue deposition in skeletal muscle. We assessed the role of periostin in fibrosis using mdx mice, an established DMD murine model, for which we conducted a thorough examination of perio
Externí odkaz:
https://doaj.org/article/5a4bd7e0587f4f5dbd16d1319112f24a
Autor:
Jamuna Selvakumaran, Simona Ursu, Melissa Bowerman, Ngoc Lu-Nguyen, Matthew J. Wood, Alberto Malerba, Rafael J. Yáñez-Muñoz
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2700 (2023)
The blood–brain barrier (BBB) is the specialised microvasculature system that shields the central nervous system (CNS) from potentially toxic agents. Attempts to develop therapeutic agents targeting the CNS have been hindered by the lack of predict
Externí odkaz:
https://doaj.org/article/14867b7d6d744afa821bb2668320729c
Autor:
Pradeep Harish, Alberto Malerba, Rosemarie H. M. J. M. Kroon, Milad Shademan, Baziel van Engelan, Vered Raz, Linda Popplewell, Stuart G. Snowden
Publikováno v:
Metabolites, Vol 13, Iss 6, p 769 (2023)
The identification of metabolomic biomarkers relies on the analysis of large cohorts of patients compared to healthy controls followed by the validation of markers in an independent sample set. Indeed, circulating biomarkers should be causally linked
Externí odkaz:
https://doaj.org/article/7b4b232f8a1a4bc39b22afcb63bb9d4d
Autor:
Vanessa Strings-Ufombah, Alberto Malerba, Shih-Chu Kao, Sonal Harbaran, Fanny Roth, Ornella Cappellari, Ngoc Lu-Nguyen, Keiko Takahashi, Sophie Mukadam, Georgina Kilfoil, Claudia Kloth, Petrus Roelvink, George Dickson, Capucine Trollet, David Suhy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 67-78 (2021)
Oculopharyngeal muscular dystrophy (OPMD) is a rare autosomal dominant disease that results from an alanine expansion in the N-terminal domain of Poly-A Binding Protein Nuclear-1 (PABPN1). We have recently demonstrated that a two-vector gene therapy
Externí odkaz:
https://doaj.org/article/a38e66f16de34830a7d74e6ea8d9e973
Autor:
Viktorija Cernisova, Ngoc Lu-Nguyen, Jessica Trundle, Shan Herath, Alberto Malerba, Linda Popplewell
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 8174 (2023)
Duchenne muscular dystrophy (DMD) is a rare neuromuscular disease affecting 1:5000 newborn males. No cure is currently available, but gene addition therapy, based on the adeno-associated viral (AAV) vector-mediated delivery of microdystrophin transge
Externí odkaz:
https://doaj.org/article/72b7832e602d4d8d822ed9b6eec6cd5d
Autor:
Haiyan Zhou, Jinhong Meng, Alberto Malerba, Francesco Catapano, Palittiya Sintusek, Susan Jarmin, Lucy Feng, Ngoc Lu‐Nguyen, Lianwen Sun, Virginie Mariot, Julie Dumonceaux, Jennifer E. Morgan, Paul Gissen, George Dickson, Francesco Muntoni
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 3, Pp 768-782 (2020)
Abstract Background Spinal muscular atrophy (SMA) is caused by genetic defects in the survival motor neuron 1 (SMN1) gene that lead to SMN deficiency. Different SMN‐restoring therapies substantially prolong survival and function in transgenic mice
Externí odkaz:
https://doaj.org/article/833a799c692e44558f9719c738478c3a
Autor:
Pradeep Harish, Alberto Malerba, Ngoc Lu‐Nguyen, Leysa Forrest, Ornella Cappellari, Fanny Roth, Capucine Trollet, Linda Popplewell, George Dickson
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 10, Iss 5, Pp 1016-1026 (2019)
Abstract Background Oculopharyngeal muscular dystrophy (OPMD) is a late‐onset muscle disease affecting one per 80 000 of the general population characterized by profound dysphagia and ptosis, and limb weakness at later stages. Affected muscles are
Externí odkaz:
https://doaj.org/article/c5412e71a06841f79b1919d787c6f2b6