Zobrazeno 1 - 10
of 295
pro vyhledávání: '"Alberto, Boffi"'
Autor:
Lorenzo Barolo, Ylenia Gigante, Lorenza Mautone, Silvia Ghirga, Alessandro Soloperto, Alessandra Giorgi, Francesca Ghirga, Martina Pitea, Alessio Incocciati, Francesco Mura, Giancarlo Ruocco, Alberto Boffi, Paola Baiocco, Silvia Di Angelantonio
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Tauopathies, including Alzheimer’s disease and Frontotemporal Dementia, are debilitating neurodegenerative disorders marked by cognitive decline. Despite extensive research, achieving effective treatments and significant symptom management
Externí odkaz:
https://doaj.org/article/d69b351b7e094759bfd10aa20ce9dd0f
Autor:
Giacomo Parisi, Roberta Piacentini, Alessio Incocciati, Alessandra Bonamore, Alberto Macone, Jakob Rupert, Elsa Zacco, Mattia Miotto, Edoardo Milanetti, Gian Gaetano Tartaglia, Giancarlo Ruocco, Alberto Boffi, Lorenzo Di Rienzo
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2024)
The development of methods able to modulate the binding affinity between proteins and peptides is of paramount biotechnological interest in view of a vast range of applications that imply designed polypeptides capable to impair or favour Protein-Prot
Externí odkaz:
https://doaj.org/article/7a5d138e1b4c4cc189f2c031fc731c96
Publikováno v:
Pharmaceuticals, Vol 17, Iss 3, p 398 (2024)
Lactoferrins and lactoferrin-derived peptides display numerous functions linked to innate immunity in mammalians, spanning from antimicrobial to anti-inflammatory and immunomodulatory actions, and even demonstrate antitumor properties. To date, the p
Externí odkaz:
https://doaj.org/article/f0ac4da9eb4e44a4b000fd8a1764ca95
Autor:
Francesca Romana Liberati, Sara Di Russo, Lorenzo Barolo, Giovanna Peruzzi, Maria Vittoria Farina, Sharon Spizzichino, Federica Di Fonzo, Deborah Quaglio, Luca Pisano, Bruno Botta, Alessandra Giorgi, Alberto Boffi, Francesca Cutruzzolà, Alessio Paone, Paola Baiocco
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 402 (2024)
Chronic lymphocytic leukemia (CLL) is a widespread type of leukemia that predominantly targets B lymphocytes, undermining the balance between cell proliferation and apoptosis. In healthy B cells, miR-15/16, a tandem of microRNAs, functions as a tumor
Externí odkaz:
https://doaj.org/article/c3cb26ae36b04029a7e08117175fdbb3
Autor:
Alessandro Soloperto, Deborah Quaglio, Paola Baiocco, Isabella Romeo, Mattia Mori, Matteo Ardini, Caterina Presutti, Ida Sannino, Silvia Ghirga, Antonia Iazzetti, Rodolfo Ippoliti, Giancarlo Ruocco, Bruno Botta, Francesca Ghirga, Silvia Di Angelantonio, Alberto Boffi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Numerous studies have shown a strong correlation between the number of neurofibrillary tangles of the tau protein and Alzheimer's disease progression, making the quantitative detection of tau very promising from a clinical point of view. How
Externí odkaz:
https://doaj.org/article/ea4bc56ead7f4f7b80769aef5c5bb896
Autor:
Mattia Miotto, Lorenzo Di Rienzo, Giorgio Gosti, Leonardo Bo’, Giacomo Parisi, Roberta Piacentini, Alberto Boffi, Giancarlo Ruocco, Edoardo Milanetti
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Miotto et al. perform molecular dynamics simulations on a selected set of possible SARS-CoV-2 spike variants in order to assess the stabilizing effect of particular amino acid substitutions on the molecular complex. Their analysis can help to monitor
Externí odkaz:
https://doaj.org/article/6610a54fcca44b15a5429e0925d0f7b2
Publikováno v:
Separations, Vol 10, Iss 7, p 414 (2023)
Recent years have witnessed remarkable progress in the field of drug delivery driven by the pursuit of efficient and targeted delivery systems [...]
Externí odkaz:
https://doaj.org/article/38978d6864f4441290f927b990581505
Autor:
Federica Palombarini, Silvia Masciarelli, Alessio Incocciati, Francesca Liccardo, Elisa Di Fabio, Antonia Iazzetti, Giancarlo Fabrizi, Francesco Fazi, Alberto Macone, Alessandra Bonamore, Alberto Boffi
Publikováno v:
Journal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-12 (2021)
Abstract Background In recent years, the use of ferritins as nano-vehicles for drug delivery is taking center stage. Compared to other similar nanocarriers, Archaeoglobus fulgidus ferritin is particularly interesting due to its unique ability to asse
Externí odkaz:
https://doaj.org/article/89baeb4218b64c8895bc7e372e5941d0
Autor:
Lorenzo Di Rienzo, Michele Monti, Edoardo Milanetti, Mattia Miotto, Alberto Boffi, Gian Gaetano Tartaglia, Giancarlo Ruocco
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3006-3014 (2021)
Since the beginning of the Covid19 pandemic, many efforts have been devoted to identifying approaches to neutralize SARS-CoV-2 replication within the host cell. A promising strategy to block the infection consists of using a mutant of the human recep
Externí odkaz:
https://doaj.org/article/6deac1cb7b4f4f21a5ea69c29a6146e5
Autor:
Lorenzo Di Rienzo, Edoardo Milanetti, Claudia Testi, Linda Celeste Montemiglio, Paola Baiocco, Alberto Boffi, Giancarlo Ruocco
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 2678-2686 (2020)
Protein-protein interactions regulate almost all cellular functions and rely on a fine tune of surface amino acids properties involved on both molecular partners. The disruption of a molecular association can be caused even by a single residue mutati
Externí odkaz:
https://doaj.org/article/592c7c1f9b1d4423a9bee4991381d46f