Self-assembly of cyclodextrins and their complexes in aqueous solutions

Autor: Sabine Inghelbrecht, Govert W. Somsen, Albertina Arien, Phennapha Saokham, Alexey Ryzhakov, Kristof Kimpe, Thorsteinn Loftsson, Laura Bertoletti, Koen Schrijnemakers, Thao Do Thi, Sergey V. Kurkov, Jef Stappaerts, Patrick Augustijns, Guy Van den Mooter, M. Ilias Jimidar, André Rodrigues Sá Couto

Publikováno v: Journal of Pharmaceutical Sciences, 105(9), 2556-2569. John Wiley and Sons Inc.
Ryzhakov, A, DoThi, T, Stappaerts, J, Bertoletti, L, Kimpe, K, Rodrigues Sa Couto, A, Saokham, P, van den Mooter, G, Augustijns, P, Somsen, G W, Kurkov, S, Inghelbrecht 4, S, Arien, A, Jimidar, M I, Schrijnemakers, K & Loftsson, T 2016, ' Self-assembly of cyclodextrins and their complexes in aqueous solutions. ', Journal of Pharmaceutical Sciences, vol. 105, no. 9, pp. 2556-2569 . https://doi.org/10.1016/j.xphs.2016.01.019

Cyclodextrins (CDs) are enabling pharmaceutical excipients that can be found in numerous pharmaceutical products worldwide. Because of their favorable toxicologic profiles, CDs are often used in toxicologic and phase I assessments of new drug candida

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5d44a134e32be35670d7d87b458ef18
https://research.vu.nl/en/publications/708efab5-e270-4d31-82b4-cae30ba03a93

Freeze-Drying of Nanosuspensions, Part 3: Investigation of Factors Compromising Storage Stability of Highly Concentrated Drug Nanosuspensions

Autor: Albertina Arien, Sabine Inghelbrecht, Jakob Beirowski, Henning Gieseler

Publikováno v: Journal of Pharmaceutical Sciences. 101:354-362

On the basis of a previously developed formulation and process guideline for lyophilized, highly concentrated drug nanosuspensions for parenteral use, it was the purpose of this study to demonstrate that the original nanoparticle size distribution ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2735643d1d857dda9e15a1138b28641
https://doi.org/10.1002/jps.22745

Passive diffusion of polymeric surfactants across lipid bilayers

Autor: André Schanck, Marcus E. Brewster, Albertina Arien, Frédéric Mathot, M. Noppe, Véronique Préat, F. Van Bambeke

Publikováno v: Journal of Controlled Release. 120:79-87

Self-assembling polymeric surfactant, mmePEG(750)P(CL-co-TMC) [monomethylether poly(ethylene glycol)(750)-poly(caprolactone-co-trimethylene carbonate)], increases drug solubility and crosses an enterocyte monolayer both in vitro and in vivo. The aims

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11738d3c9a40752bd95864e62b603a7b
https://doi.org/10.1016/j.jconrel.2007.03.015

The effect of supercritical CO2 as a reversible plasticizer and foaming agent on the hot stage extrusion of itraconazole with EC 20cps

Autor: Patrick Rombaut, Koen Heymans, Annelies Decorte, Jef Peeters, Albertina Arien, Marcus E. Brewster, Guy Van den Mooter, Dehua Liu, Jef Adriaensen, David L. Tomasko, Geert Verreck

Publikováno v: The Journal of Supercritical Fluids. 40:153-162

The aim of the current research project was to explore the possibilities of combining pressurized carbon dioxide with hot stage extrusion during manufacturing of solid dispersions of itraconazole and ethylcellulose 20 cps (EC 20 cps), to evaluate the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3566ec1b1e6af6449c77bf8aea6cee39
https://doi.org/10.1016/j.supflu.2006.05.005

The effect of pressurized carbon dioxide as a plasticizer and foaming agent on the hot melt extrusion process and extrudate properties of pharmaceutical polymers

Autor: Annelies Decorte, Jef Peeters, Geert Verreck, David L. Tomasko, Patrick Rombaut, Marcus E. Brewster, Guy Van den Mooter, Albertina Arien, Hongbo Li

Publikováno v: The Journal of Supercritical Fluids. 38:383-391

The aim of the current research project was to explore the possibilities of combining pressurized carbon dioxide with hot melt extrusion of polyvinylpyrrolidone-co-vinyl acetate 64, Eudragit ® E100 and ethylcellulose 20 cps, to evaluate the ability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44fd58390e6c9dc2db770bab60f7f641
https://doi.org/10.1016/j.supflu.2005.11.022