Reconstruction of the pulmonary artery by a novel biodegradable conduit engineered with perinatal stem cell-derived vascular smooth muscle cells enables physiological vascular growth in a large animal model of congenital heart disease

Autor: Ghorbel, Mohamed T., Jia, Huidong, Swim, Megan M., Iacobazzi, Dominga, Albertario, Ambra, Zebele, Carlo, Holopherne-Doran, Delphine, Hollander, Anthony, Madeddu, Paolo, Caputo, Massimo

Publikováno v: In Biomaterials October 2019 217

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Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine

Autor: Albertario, Ambra, Swim, Megan M., Ahmed, Eltayeb Mohamed, Iacobazzi, Dominga, Yeong, Michael, Madeddu, Paolo, Ghorbel, Mohamed T., Caputo, Massimo

Publikováno v: Albertario, A, Swim, M M, Mohamed Ahmed, E, Iacobazzi, D, Yeong, M, Madeddu, P, Ghorbel, M & Caputo, M 2019, ' Successful Reconstruction of the Right Ventricular Outflow Tract by Implantation of Thymus Stem Cell Engineered Graft in Growing Swine ', JACC: Basic to Translational Science, vol. 4, no. 3, pp. 364-384 . https://doi.org/10.1016/j.jacbts.2019.02.001
JACC: Basic to Translational Science

Visual Abstract
Highlights • T-MSCs were isolated from the thymus gland of new born pigs, expanded, characterized and seeded onto a commercially available scaffold. • The seeded-grafts were cultured within a bioreactor and then used to recon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::79c4c0905eb2596f4840472e6e1bf547
https://pubmed.ncbi.nlm.nih.gov/31312760

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Development of stem cell tissue engineered patches and assessment of their potential for corrective heart surgery using a cardiopulmonary bypass swine model

Autor: Albertario, Ambra

Congenital Heart Defects (CHDs) are the leading global cause of death in the first year of life. Truncus Arteriosus (TA) is a CHD characterized by a common aorta/pulmonary artery and a ventricular septal defect. When treating paediatric patients with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______341::28a0a15ad11fc570082a7489d39e6b3d
http://hdl.handle.net/1889/3374