Correction to: Clinical trial-ready patient cohorts for multiple system atrophy: coupling biospecimen and iPSC banking to longitudinal deep-phenotyping

Autor: Alain Ndayisaba, Ariana T. Pitaro, Andrew S. Willett, Kristie A. Jones, Claudio Melo de Gusmao, Abby L. Olsen, Jisoo Kim, Eero Rissanen, Jared K. Woods, Sharan R. Srinivasan, Anna Nagy, Amanda Nagy, Merlyne Mesidor, Steven Cicero, Viharkumar Patel, Derek H. Oakley, Idil Tuncali, Katherine Taglieri-Noble, Emily C. Clark, Jordan Paulson, Richard C. Krolewski, Gary P. Ho, Albert Y. Hung, Anne-Marie Wills, Michael T. Hayes, Jason P. Macmore, Luigi Warren, Pamela G. Bower, Carol B. Langer, Lawrence R. Kellerman, Christopher W. Humphreys, Bonnie I. Glanz, Elodi J. Dielubanza, Matthew P. Frosch, Roy L. Freeman, Christopher H. Gibbons, Nadia Stefanova, Tanuja Chitnis, Howard L. Weiner, Clemens R. Scherzer, Sonja W. Scholz, Dana Vuzman, Laura M. Cox, Gregor Wenning, Jeremy D. Schmahmann, Anoopum S. Gupta, Peter Novak, Geoffrey S. Young, Mel B. Feany, Tarun Singhal, Vikram Khurana

Publikováno v: The Cerebellum.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7951ae47ca6c7e4babafd17fdca7078
https://doi.org/10.1007/s12311-022-01501-5

β-Glucocerebrosidase activity in GBA-linked Parkinson disease

Autor: Ann L. Hunt, John H. Growdon, Ganqiang Liu, Bradley T. Hyman, Joseph J. Locascio, Stephen N. Gomperts, Clemens R. Scherzer, Yuliya I. Kuras, Aleksandar Videnovic, Albert Y. Hung, Michael A. Schwarzschild, Anne-Marie Wills, Michael T. Hayes, Idil Tuncali, Todd M. Herrington, Ming Sum Ruby Chiang, Zhixiang Liao, Young Eun Huh, Karbi Choudhury, Sergio Pablo Sardi

Publikováno v: Neurology. 95:e685-e696

ObjectiveTo test the relationship between clinically relevant types of GBA mutations (none, risk variants, mild mutations, severe mutations) and β-glucocerebrosidase activity in patients with Parkinson disease (PD) in cross-sectional and longitudina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0609737a9108fdcfcf141150d1711f3e
https://doi.org/10.1212/wnl.0000000000009989

Effect of Urate-Elevating Inosine on Early Parkinson Disease Progression: The SURE-PD3 Randomized Clinical Trial

Autor: Tanya Simuni, Holly A. Shill, Matthew Brodsky, Marcie Rabin, Michael A. Schwarzschild, Kenneth Marek, Cheryl Waters, Cindy Casaceli, Steven A. Gunzler, Stephen G. Reich, Codrin Lungu, Sarah Elizabeth Zauber, Kellie Keith, Shyamal H. Mehta, Dariush Mozaffarian, Valerie Suski, Marie Saint-Hilaire, John L. Goudreau, Alice Rudolph, Ruth B. Schneider, Aaron Daley, Eric A. Macklin, Zoltan Mari, Grace F. Crotty, Andres Deik, Alberto J. Espay, Ashley Laroche, Sherri Mosovsky, Joohi Jimenez-Shahed, Mark S. LeDoux, Cynthia Poon, Ashley Gerald, John C. Morgan, Carolyn Peterson, Joseph H. Friedman, David Klements, Robert A. Hauser, Doozie Russell, David Simon, Kathrin LaFaver, Vanessa K. Hinson, Richard B. Dewey, Melissa Ainslie, Jason Aldred, Tiago A. Mestre, John Y. Fang, Liana S. Rosenthal, Grace Bwala, Raymond C. James, Binit B. Shah, Gearoid M. McMahon, Ariane Park, Rajeev Kumar, Lin Zhang, Ivan Bodis-Wollner, Mya C. Schiess, Katherine F. Callahan, David Oakes, Kelvin L. Chou, Melissa Kostrzebski, Roger Kurlan, Lisa Gauger, Albert Y. Hung, Melissa Bixby, Ira Shoulson, Michael Soileau, James T. Boyd, Peter A LeWitt, Burton L. Scott, Claire Henchcliffe, Patricia Kaminski, Alberto Ascherio, Cornelia Kamp, Lindsay Pothier, Anwar Ahmed, Jill Ciccarello, David J. Houghton, April Langhammer, Rebecca Fitzgerald, Maureen A. Leehey, Anthony E. Lang, Carmen Serrano, Martha McGraw, David Shprecher, Jennifer Durphy, Aleksandar Videnovic, Danish Bhatti, Christine Hunter, Amber Servi Ratel, J. Antonelle de Marcaida, Christopher G. Goetz, Emily Houston, Rajesh Pahwa, Chadwick W. Christine, Gary C. Curhan, Irene Litvan, Christopher A. Beck, Leslie J. Cloud, Patrick Bolger, Karen Thomas, Natividad Stover, Karen Blindauer, Sushrut S. Waikar, Susan R. Criswell

Publikováno v: JAMA

IMPORTANCE: Urate elevation, despite associations with crystallopathic, cardiovascular, and metabolic disorders, has been pursued as a potential disease-modifying strategy for Parkinson disease (PD) based on convergent biological, epidemiological, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4608ea519947a922d23da1991ccca9
https://europepmc.org/articles/PMC8441591/

Sex differences by design and outcome in the Safety of Urate Elevation in PD (SURE-PD) trial

Autor: Albert Y. Hung, David S. Russell, Michael A. Schwarzschild, Eric A. Macklin, Marie Saint-Hilaire, Gary C. Curhan, Grace Bwala, Joshua M. Hare, Alice Rudolph, Christopher G. Goetz, Shamik Battacharyya, Rachit Bakshi, Robert Logan, John L. Goudreau, Sotirios A. Parashos, Alberto J. Espay, Alberto Ascherio

Publikováno v: Neurology

ObjectiveTo investigate whether women and men with Parkinson disease (PD) differ in their biochemical and clinical responses to long-term treatment with inosine.MethodsThe Safety of Urate Elevation in Parkinson’s Disease (SURE-PD) trial enrolled 75

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2017650bb524175e9fedb8686212a3a9
https://doi.org/10.1212/wnl.0000000000008194

Approaches to Disease Modification for Parkinson's Disease: Clinical Trials and Lessons Learned

Autor: Michael A. Schwarzschild, Albert Y. Hung

Publikováno v: Neurotherapeutics

Despite many clinical trials over the last three decades, the goal of demonstrating that a treatment slows the progression of Parkinson’s disease (PD) remains elusive. Research advances have shed new insight into cellular pathways contributing to P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f44e0c0409982e94f60dfcffd036d2a
https://pubmed.ncbi.nlm.nih.gov/33205384