Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Albert W. H. Neitz"'
Autor:
Albert W. H. Neitz, Mohammed Auwal Ibrahim, June C. Serem, Anabella R.M. Gaspar, Megan Jean Bester
Publikováno v:
International Journal of Peptide Research and Therapeutics. 26:1949-1963
Type 2 diabetes mellitus (T2DM) is a multifactorial disease that requires multiple therapeutic strategies for its management. Bioactive peptides with multiple anti-diabetic targets are attractive therapeutic molecules. The present study was conducted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33e18cc658af60da933142c57617b043
https://doi.org/10.1007/s10989-019-09993-2
https://doi.org/10.1007/s10989-019-09993-2
Publikováno v:
Biomedicine & Pharmacotherapy. 107:234-242
Treatment of type 2 diabetes is achieved through the inhibition of carbohydrate hydrolyzing enzymes such as α-glucosidase and α-amylase. The present study was conducted to identify novel α-glucosidase inhibitory peptides and to validate the α-glu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c112fb05d1a453b85033af4dd69df2ea
https://doi.org/10.1016/j.biopha.2018.07.163
https://doi.org/10.1016/j.biopha.2018.07.163
Publikováno v:
International Journal of Peptide Research and Therapeutics. 25:437-446
In silico analysis was used to evaluate storage proteins from plant tubers as potential precursors of bioactive peptides after simulated gastrointestinal digestion. Proteins derived from potato (patatins), sweet potato (sporamins), yam (dioscorins) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0133e95d37a073fc25c0c9eccb00eca2
https://doi.org/10.1007/s10989-018-9688-7
https://doi.org/10.1007/s10989-018-9688-7
Autor:
Megan Jean Bester, Yasien Sayed, Adam A. Strömstedt, Clerisa Odendaal, Anabella R.M. Gaspar, Albert W. H. Neitz, June C. Serem, Naadhira O. Ismail
Publikováno v:
Journal of Peptide Science. 25
Previously Os, a 22 amino acid sequence of a defensin from the soft tick Ornithodoros savignyi, was found to kill Gram-positive and Gram-negative bacteria at low micromolar concentrations. In this study, we evaluated synthetic peptide analogues of Os
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1181dbf4846621e80dba3bb2cb89dcf1
https://doi.org/10.1002/psc.3223
https://doi.org/10.1002/psc.3223
Autor:
Megan Jean Bester, Mohammed Auwal Ibrahim, Albert W. H. Neitz, Anabella R.M. Gaspar, June C. Serem
Publikováno v:
Protein and peptide letters. 26(6)
Background: Peptide-based therapeutics offer a unique avenue for the development of novel agents for the treatment of diabetes mellitus including α-glucosidase inhibitors. The peptide, SQSPA, was reported to possess to α -glucosidase inhibitory act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee76fb3154967a1e56fcf9c6b43f54d8
https://pubmed.ncbi.nlm.nih.gov/30919765
https://pubmed.ncbi.nlm.nih.gov/30919765
Publikováno v:
Journal of Peptide Science. 22:43-51
Antimicrobial peptides are small cationic peptides that possess a large spectrum of bioactivities, including antimicrobial, anti-inflammatory and antioxidant activities. Several antimicrobial peptides are known to inhibit lipopolysaccharide (LPS)-ind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db5f3a67ed24a3387bad30991a6e7d68
https://doi.org/10.1002/psc.2838
https://doi.org/10.1002/psc.2838
Autor:
Anabella R.M. Gaspar, Albert W. H. Neitz, Mohammed Auwal Ibrahim, Megan Jean Bester, June C. Serem
Publikováno v:
International journal of biological macromolecules. 122
Antidiabetic agents with multiple targets have the greatest pharmaceutical potential. In this study, three α-glucosidase inhibitory peptides, PFP, YPL and YPG, were investigated for additional antidiabetic targets viz.; dipeptidyl peptidase-IV inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fec09a0cc6bd689b5fae3884a0928d
https://pubmed.ncbi.nlm.nih.gov/30365987
https://pubmed.ncbi.nlm.nih.gov/30365987
Publikováno v:
Veterinary Sciences
In comparison to other arachnids, ticks are major vectors of disease, but less than 8% of the known species are capable of inducing paralysis, as compared to the ~99–100% arachnids that belong to venomous classes. When considering the potential mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a604760673b6f3fd1d73cf5a84a97063
https://pubmed.ncbi.nlm.nih.gov/29757990
https://pubmed.ncbi.nlm.nih.gov/29757990
Publikováno v:
Peptides. 71:179-187
Os and Os-C are two novel antimicrobial peptides, derived from a tick defensin, which have been shown to have a larger range of antimicrobial activity than the parent peptide, OsDef2. The aim of this study was to determine whether the peptides Os and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ddd240b00deeb4968e818e4ae942607
https://doi.org/10.1016/j.peptides.2015.07.017
https://doi.org/10.1016/j.peptides.2015.07.017
Publikováno v:
Chemical biologydrug design. 91(2)
Bioactive peptides are emerging as promising class of drugs that could serve as α-glucosidase inhibitors for the treatment of type 2 diabetes. This article identifies structural and physicochemical requirements for the design of therapeutically rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12fdafceb162667e79f468f9a999c40
https://pubmed.ncbi.nlm.nih.gov/28884942
https://pubmed.ncbi.nlm.nih.gov/28884942