Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Albert W Cheng"'
Autor:
Yarden Katz, Feifei Li, Nicole J Lambert, Ethan S Sokol, Wai-Leong Tam, Albert W Cheng, Edoardo M Airoldi, Christopher J Lengner, Piyush B Gupta, Zhengquan Yu, Rudolf Jaenisch, Christopher B Burge
Publikováno v:
eLife, Vol 3 (2014)
The conserved Musashi (Msi) family of RNA binding proteins are expressed in stem/progenitor and cancer cells, but generally absent from differentiated cells, consistent with a role in cell state regulation. We found that Msi genes are rarely mutated
Externí odkaz:
https://doaj.org/article/1bcc618553ce4884a9566906671808ea
Autor:
Michael A Lodato, Christopher W Ng, Joseph A Wamstad, Albert W Cheng, Kevin K Thai, Ernest Fraenkel, Rudolf Jaenisch, Laurie A Boyer
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003288 (2013)
SOX2 is a master regulator of both pluripotent embryonic stem cells (ESCs) and multipotent neural progenitor cells (NPCs); however, we currently lack a detailed understanding of how SOX2 controls these distinct stem cell populations. Here we show by
Externí odkaz:
https://doaj.org/article/02a27a75c5fb421e971eff1e44cbf4c4
Autor:
Irina M Shapiro, Albert W Cheng, Nicholas C Flytzanis, Michele Balsamo, John S Condeelis, Maja H Oktay, Christopher B Burge, Frank B Gertler
Publikováno v:
PLoS Genetics, Vol 7, Iss 8, p e1002218 (2011)
Epithelial-mesenchymal transition (EMT), a mechanism important for embryonic development, plays a critical role during malignant transformation. While much is known about transcriptional regulation of EMT, alternative splicing of several genes has al
Externí odkaz:
https://doaj.org/article/1155c6be6fce4575882391d9737d933b
Autor:
Aziz Taghbalout, Menghan Du, Nathaniel Jillette, Wojciech Rosikiewicz, Abhijit Rath, Christopher D. Heinen, Sheng Li, Albert W. Cheng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
DNA methylation plays an important role in regulating a wide variety of cellular processes and is implicated in a range of diseases. Here the authors present Casilio-ME to assemble protein complexes to demethylate target loci.
Externí odkaz:
https://doaj.org/article/6bfa03502fb24550a614110069d7480f
Autor:
Roel G.W. Verhaak, Albert W. Cheng, Patricia A. Clow, Nathaniel Jillette, Sunit Das, Qianru Yu, Megan L. Costa, Samirkumar B. Amin, Kevin C. Johnson, Dacheng Zhao, Hoon Kim, Molly Guthrie, Amit D. Gujar, Eunhee Yi
Supplementary Figures 1-26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23501318d0da2a1f2a732924ae33fc98
https://doi.org/10.1158/2159-8290.22540790.v1
https://doi.org/10.1158/2159-8290.22540790.v1
Autor:
Roel G.W. Verhaak, Albert W. Cheng, Patricia A. Clow, Nathaniel Jillette, Sunit Das, Qianru Yu, Megan L. Costa, Samirkumar B. Amin, Kevin C. Johnson, Dacheng Zhao, Hoon Kim, Molly Guthrie, Amit D. Gujar, Eunhee Yi
Oncogenic extrachromosomal DNA elements (ecDNA) play an important role in tumor evolution, but our understanding of ecDNA biology is limited. We determined the distribution of single-cell ecDNA copy number across patient tissues and cell line models
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a88643c243e39b9460b64613fae1d5b7
https://doi.org/10.1158/2159-8290.c.6549473.v1
https://doi.org/10.1158/2159-8290.c.6549473.v1
Publikováno v:
ACS Synth Biol
Here we describe TALE.Sense, a versatile platform for sensing DNA sequences in live mammalian cells enabling programmable generation of a customable response that discerns cells containing specified sequence targets. The platform is based on the prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe8a7a295d75f880ac86aa16be1c6ed
https://doi.org/10.1021/acssynbio.1c00212
https://doi.org/10.1021/acssynbio.1c00212
Autor:
Rachel Lasry, Noam Maoz, Albert W. Cheng, Nataly Yom Tov, Elisabeth Kulenkampff, Meir Azagury, Hui Yang, Cora Ople, Styliani Markoulaki, Dina A. Faddah, Kirill Makedonski, Ofra Sabbag, Rudolf Jaenisch, Yosef Buganim
A complete knockout (KO) of a single key pluripotency gene has been shown to drastically affect embryonic stem cell (ESC) function and epigenetic reprogramming. However, knockin (KI)/KO of a reporter gene only in one of two alleles in a single plurip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf279f3ce01365409347813a3802c36f
https://doi.org/10.1101/2022.05.18.492474
https://doi.org/10.1101/2022.05.18.492474
CRISPR-Cas technologies enable precise editing of genomic sequences. One major way to introduce precise editing is through homology directed repair (HDR) of DNA double strand breaks (DSB) templated by exogenously supplied single-stranded oligodeoxyri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c55512ff3227e3d285a917d5d861e712
https://doi.org/10.1101/2022.04.13.488255
https://doi.org/10.1101/2022.04.13.488255
Autor:
Patricia A. Clow, Menghan Du, Nathaniel Jillette, Aziz Taghbalout, Jacqueline J. Zhu, Albert W. Cheng
Publikováno v:
Nature Communications. 13
Three-dimensional (3D) structures of the genome are dynamic, heterogeneous and functionally important. Live cell imaging has become the leading method for chromatin dynamics tracking. However, existing CRISPR- and TALE-based genomic labeling techniqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60a06d5693fb0d2722fba7a0408309da
https://doi.org/10.1038/s41467-022-29343-z
https://doi.org/10.1038/s41467-022-29343-z