Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Albert T. Higgins-Chen"'
Autor:
Alina P. S. Pang, Albert T. Higgins-Chen, Florence Comite, Ioana Raica, Christopher Arboleda, Hannah Went, Tavis Mendez, Michael Schotsaert, Varun Dwaraka, Ryan Smith, Morgan E. Levine, Lishomwa C. Ndhlovu, Michael J. Corley
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The host epigenetic landscape rapidly changes during SARS-CoV-2 infection, and evidence suggest that severe COVID-19 is associated with durable scars to the epigenome. Specifically, aberrant DNA methylation changes in immune cells and alterations to
Externí odkaz:
https://doaj.org/article/b77f973272304187808a89b6508d8ed7
Autor:
Albert T. Higgins-Chen, Sarah B. Abdallah, Jennifer B. Dwyer, Alfred P. Kaye, Gustavo A. Angarita, Michael H. Bloch
Publikováno v:
Frontiers in Psychiatry, Vol 10 (2019)
Illness anxiety disorder (IAD, formerly hypochondriasis) is characterized by preoccupation with fear of serious illness despite medical reassurance. IAD is common, debilitating, challenging to treat, and results in high healthcare utilization. Outpat
Externí odkaz:
https://doaj.org/article/beb64882977c42c2b37b812ea2e11afb
Autor:
Albert T. Higgins-Chen, Kyra L. Thrush, Yunzhang Wang, Christopher J. Minteer, Pei-Lun Kuo, Meng Wang, Peter Niimi, Gabriel Sturm, Jue Lin, Ann Zenobia Moore, Stefania Bandinelli, Christiaan H. Vinkers, Eric Vermetten, Bart P. F. Rutten, Elbert Geuze, Cynthia Okhuijsen-Pfeifer, Marte Z. van der Horst, Stefanie Schreiter, Stefan Gutwinski, Jurjen J. Luykx, Martin Picard, Luigi Ferrucci, Eileen M. Crimmins, Marco P. Boks, Sara Hägg, Tina T. Hu-Seliger, Morgan E. Levine
Publikováno v:
Nature aging, 2(7), 644-661. Nature Publishing Group
Nature Aging, 2(7), 644-661. Springer
Higgins-Chen, A T, Thrush, K L, Wang, Y, Minteer, C J, Kuo, P-L, Wang, M, Niimi, P, Sturm, G, Lin, J, Moore, A Z, Bandinelli, S, Vinkers, C H, Vermetten, E, Rutten, B P F, Geuze, E, Okhuijsen-Pfeifer, C, van der Horst, M Z, Schreiter, S, Gutwinski, S, Luykx, J J, Picard, M, Ferrucci, L, Crimmins, E M, Boks, M P, Hägg, S, Hu-Seliger, T T & Levine, M E 2022, ' A computational solution for bolstering reliability of epigenetic clocks : implications for clinical trials and longitudinal tracking ', Nature Aging, vol. 2, no. 7, pp. 644-661 . https://doi.org/10.1038/s43587-022-00248-2
Nature Aging, 2(7), 644-661. Springer
Higgins-Chen, A T, Thrush, K L, Wang, Y, Minteer, C J, Kuo, P-L, Wang, M, Niimi, P, Sturm, G, Lin, J, Moore, A Z, Bandinelli, S, Vinkers, C H, Vermetten, E, Rutten, B P F, Geuze, E, Okhuijsen-Pfeifer, C, van der Horst, M Z, Schreiter, S, Gutwinski, S, Luykx, J J, Picard, M, Ferrucci, L, Crimmins, E M, Boks, M P, Hägg, S, Hu-Seliger, T T & Levine, M E 2022, ' A computational solution for bolstering reliability of epigenetic clocks : implications for clinical trials and longitudinal tracking ', Nature Aging, vol. 2, no. 7, pp. 644-661 . https://doi.org/10.1038/s43587-022-00248-2
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data, but this data can be surprisingly unreliable. Here we show technical noise produces deviations up to 9 years between replicates for six prominent epigenetic cloc
Publikováno v:
Harvanek, Z M, Boks, M P, Vinkers, C H & Higgins-Chen, A T 2023, ' The Cutting Edge of Epigenetic Clocks : In Search of Mechanisms Linking Aging and Mental Health ', Biological Psychiatry . https://doi.org/10.1016/j.biopsych.2023.02.001
Individuals with psychiatric disorders are at increased risk of age-related diseases and early mortality. Recent studies demonstrate that this link between mental health and aging is reflected in epigenetic clocks, aging biomarkers based on DNA methy
Publikováno v:
Semin Cell Dev Biol
Quantifying biological aging is critical for understanding why aging is the primary driver of morbidity and mortality and for assessing novel therapies to counter pathological aging. In the past decade, many biomarkers relevant to brain aging have be
BackgroundEpigenetic clocks are promising tools for the study of aging in humans. The clocks quantify biological aging above and beyond chronological age, demonstrate systematic associations with risk factors that accelerate aging, and predict age-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14940b3f70c2e50ac6a07f7fae98463e
https://doi.org/10.1101/2022.07.13.499978
https://doi.org/10.1101/2022.07.13.499978
Autor:
Kyra L. Thrush, David A. Bennett, Christopher Gaiteri, Steve Horvath, Christopher H. van Dyck, Albert T. Higgins-Chen, Morgan E. Levine
Publikováno v:
Aging. 14(14)
Alzheimer's disease (AD) risk increases exponentially with age and is associated with multiple molecular hallmarks of aging, one of which is epigenetic alterations. Epigenetic age predictors based on 5' cytosine methylation (DNAm), or epigenetic cloc
Publikováno v:
Biological Psychiatry, 88(3), 224-235. Elsevier USA
Higgins-Chen, A T, Boks, M P, Vinkers, C H, Kahn, R S & Levine, M E 2020, ' Schizophrenia and Epigenetic Aging Biomarkers : Increased Mortality, Reduced Cancer Risk, and Unique Clozapine Effects ', Biological Psychiatry, vol. 88, no. 3, pp. 224-235 . https://doi.org/10.1016/j.biopsych.2020.01.025
Higgins-Chen, A T, Boks, M P, Vinkers, C H, Kahn, R S & Levine, M E 2020, ' Schizophrenia and Epigenetic Aging Biomarkers : Increased Mortality, Reduced Cancer Risk, and Unique Clozapine Effects ', Biological Psychiatry, vol. 88, no. 3, pp. 224-235 . https://doi.org/10.1016/j.biopsych.2020.01.025
Background Schizophrenia (SZ) is associated with increased all-cause mortality, smoking, and age-associated proteins, yet multiple previous studies found no association between SZ and biological age using Horvath’s epigenetic clock, a well-establis
Autor:
Alina PS Pang, Albert T. Higgins-Chen, Florence Comite, Ioana Raica, Christopher Arboleda, Hannah Went, Tavis Mendez, Michael Schotsaert, Varun Dwaraka, Ryan Smith, Morgan E. Levine, Lishomwa C. Ndhlovu, Michael J. Corley
Publikováno v:
Frontiers in genetics. 13
The host epigenetic landscape rapidly changes during SARS-CoV-2 infection, and evidence suggest that severe COVID-19 is associated with durable scars to the epigenome. Specifically, aberrant DNA methylation changes in immune cells and alterations to
Autor:
Stefania Bandinelli, Yunzhang Wang, Elbert Geuze, Eileen M. Crimmins, Christopher Minteer, Meng Wang, Stefanie Schreiter, Marco P. Boks, Albert T. Higgins-Chen, Ann Zenobia Moore, Pei-Lun Kuo, Morgan E. Levine, Jurjen J. Luykx, Marte Z. van der Horst, Bart P. F. Rutten, Sara Hägg, Kyra Thrush, Eric Vermetten, Luigi Ferrucci, Cynthia Okhuijsen-Pfeifer, Stefan Gutwinski, Christiaan H. Vinkers, Tina T. Hu-Seliger
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data. Unfortunately, measurements for individual CpGs can be surprisingly unreliable due to technical noise, and this may limit the utility of epigenetic clocks. We re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eea51c47e3e3aa0e65733fecc0ade2c
https://doi.org/10.1101/2021.04.16.440205
https://doi.org/10.1101/2021.04.16.440205