Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Albert S. W. Sohn"'
Autor:
Seth J. Parker, Joel Encarnación-Rosado, Kate E. R. Hollinshead, David M. Hollinshead, Leonard J. Ash, Juan A. K. Rossi, Elaine Y. Lin, Albert S. W. Sohn, Mark R. Philips, Drew R. Jones, Alec C. Kimmelman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Analogues of α-ketoglutarate are used in many cellular studies but assumptions are made about cellular uptake. Here, the authors show that esterified analogues rapidly hydrolyse in aqueous medium resulting in an analogue which can be quickly taken u
Externí odkaz:
https://doaj.org/article/a430c84ac3014555b5b20af966982f02
Autor:
Douglas E. Biancur, Joao A. Paulo, Beata Małachowska, Maria Quiles Del Rey, Cristovão M. Sousa, Xiaoxu Wang, Albert S. W. Sohn, Gerald C. Chu, Steven P. Gygi, J. Wade Harper, Wojciech Fendler, Joseph D. Mancias, Alec C. Kimmelman
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Glutaminase inhibition (GLSi) has promising activity against certain cancers. Here, the authors show that GLSi has no effect on multiple mouse models of pancreatic cancer and characterize the metabolic pathways activated in response to GLSi whose con
Externí odkaz:
https://doaj.org/article/3c1c97f9f96f44b8b385caffd639b374
Autor:
Joseph D. Mancias, Seth J. Parker, Mark R. Philips, Drew R. Jones, Alec C. Kimmelman, Doug E. Biancur, Steven P. Gygi, Joao A. Paulo, Qijia Yu, Albert S. W. Sohn, Kate E.R. Hollinshead, Keisuke Yamamoto, Rebecca E. Rose, Joel Encarnación-Rosado, Madeleine M. LaRue, Caroline R. Amendola, Huamin Wang, Dafna Bar-Sagi
Publikováno v:
Cancer Discov
Pancreatic ductal adenocarcinoma (PDAC) evolves a complex microenvironment comprised of multiple cell types, including pancreatic stellate cells (PSC). Previous studies have demonstrated that stromal supply of alanine, lipids, and nucleotides support
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c91019722e5bddd9dc300472d58443e1
https://doi.org/10.1158/2159-8290.cd-19-0959
https://doi.org/10.1158/2159-8290.cd-19-0959
Autor:
David M. Hollinshead, Alec C. Kimmelman, Elaine Y. Lin, Mark R. Philips, Juan A. Kochen Rossi, Seth J. Parker, Albert S. W. Sohn, Leonard J. Ash, Joel Encarnación-Rosado, Kate E.R. Hollinshead, Drew R. Jones
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
α-ketoglutarate (KG), also referred to as 2-oxoglutarate, is a key intermediate of cellular metabolism with pleiotropic functions. Cell-permeable esterified analogs are widely used to study how KG fuels bioenergetic and amino acid metabolism and DNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee28be91e2da97e7b31a7249bcc0a44c
http://europepmc.org/articles/PMC8361106
http://europepmc.org/articles/PMC8361106
Autor:
Albert S. W. Sohn, Keisuke Yamamoto, Quentin Spillier, Michael E. Pacold, Guangbin Shi, Robert S. Banh, Esther S. Kim, Alec C. Kimmelman, Drew R. Jones, Douglas E. Biancur
Publikováno v:
Nature
Oxygen is critical for a multitude of metabolic processes that are essential for human life. Biological processes can be identified by treating cells with 18O2 or other isotopically labelled gases and systematically identifying biomolecules incorpora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016c0d50b705c5e084c73dc631830716
https://pubmed.ncbi.nlm.nih.gov/34471290
https://pubmed.ncbi.nlm.nih.gov/34471290
Autor:
Adam Brown, Keisuke Yamamoto, David E. Root, Alec C. Kimmelman, Andrew J. Aguirre, Jasper E. Neggers, Warren L. Wu, Robert S. Banh, Albert S. W. Sohn, Robert T. Manguso, Douglas E. Biancur, Kevin S. Kapner
Publikováno v:
Cell Metab
Summary Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer characterized by complex metabolic adaptations that promote survival in a severely hypoxic and nutrient-limited tumor microenvironment (TME). Modeling microenvironmental influences in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb0ba94959f4657ef6baa06a269a907
https://doi.org/10.1016/j.cmet.2020.10.018
https://doi.org/10.1016/j.cmet.2020.10.018
Autor:
Beth Walters, Ajami Gikandi, Robert S. Banh, Douglas E. Biancur, Alec C. Kimmelman, Huamin Wang, Miljan Kuljanin, Keisuke Yamamoto, Joseph D. Mancias, Albert S. W. Sohn, Michael E. Pacold, Robert J. Schneider
Publikováno v:
Cell. 183:1202-1218.e25
Pancreatic ductal adenocarcinoma (PDAC) tumors have a nutrient-poor, desmoplastic, and highly innervated tumor microenvironment. Although neurons can release stimulatory factors to accelerate PDAC tumorigenesis, the metabolic contribution of peripher
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40fab89d658a891e1577a62ad94ff409
https://doi.org/10.1016/j.cell.2020.10.016
https://doi.org/10.1016/j.cell.2020.10.016
Autor:
Maria Quiles Del Rey, Gerald C. Chu, Joao A. Paulo, J. Wade Harper, Alec C. Kimmelman, Joseph D. Mancias, Xiaoxu Wang, Douglas E. Biancur, Albert S. W. Sohn, Beata Małachowska, Cristovão M. Sousa, Steven P. Gygi, Wojciech Fendler
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Pancreatic ductal adenocarcinoma is a notoriously difficult-to-treat cancer and patients are in need of novel therapies. We have shown previously that these tumours have altered metabolic requirements, making them highly reliant on a number of adapta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d779e5d13d3b0ef4cfb0d41f092d29
https://pubmed.ncbi.nlm.nih.gov/28671190
https://pubmed.ncbi.nlm.nih.gov/28671190