Zobrazeno 1 - 10
of 302
pro vyhledávání: '"Albert S. Baldwin"'
Autor:
Yuanli Zhen, Kai Liu, Lei Shi, Simran Shah, Qin Xu, Haley Ellis, Eranga R. Balasooriya, Johannes Kreuzer, Robert Morris, Albert S. Baldwin, Dejan Juric, Wilhelm Haas, Nabeel Bardeesy
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Genomic alterations that activate Fibroblast Growth Factor Receptor 2 (FGFR2) are common in intrahepatic cholangiocarcinoma (ICC) and confer sensitivity to FGFR inhibition. However, the depth and duration of response is often limited. Here,
Externí odkaz:
https://doaj.org/article/5cd054ddc21245bf928ef895954d9dac
Autor:
Ahmet K. Korkaya, Jeffrey Fischer, Anthony Peppers, Sean M. Crosson, Manira Rayamajhi, Edward A. Miao, Albert S. Baldwin, Jennifer W. Bradford
Publikováno v:
Innate Immunity, Vol 29 (2023)
Here, we describe the production and characterization of a novel p65 fl/fl /LysMCre mouse model, which lacks canonical nuclear factor-kappaB member RelA/p65 (indicated as p65 hereafter) in bone marrow-derived macrophages. Cultured bone marrow-derived
Externí odkaz:
https://doaj.org/article/19c92616d7fb4835a876189233035ff3
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107115- (2023)
Summary: The histone methyltransferase EZH2 has been studied most extensively in the context of PRC2-dependent gene repression. Accumulating evidence indicates non-canonical functions for EZH2 in cancer contexts including promoting paradoxical gene e
Externí odkaz:
https://doaj.org/article/05129ec8ef54481fbaac6ad06e66a2d4
Autor:
Tarmo Äijö, Dimitris Theofilatos, Meng Cheng, Matthew D. Smith, Yue Xiong, Albert S. Baldwin, Ageliki Tsagaratou
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
TET proteins mediate DNA demethylation by oxidizing 5-methylcytosine to 5-hydroxymethylcytosine (5hmC) and other oxidative derivatives. We have previously demonstrated a dynamic enrichment of 5hmC during T and invariant natural killer T cell lineage
Externí odkaz:
https://doaj.org/article/c3cdb185ee6a4a8ab117f4bf7075dbf2
Autor:
Alessandro Porrello, Patrick L. Leslie, Emily B. Harrison, Balachandra K. Gorentla, Sravya Kattula, Subrata K. Ghosh, Salma H. Azam, Alisha Holtzhausen, Yvonne L. Chao, Michele C. Hayward, Trent A. Waugh, Sanggyu Bae, Virginia Godfrey, Scott H. Randell, Cecilia Oderup, Liza Makowski, Jared Weiss, Matthew D. Wilkerson, D. Neil Hayes, H. Shelton Earp, Albert S. Baldwin, Alisa S. Wolberg, Chad V. Pecot
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Lung squamous carcinomas (LUSC) are poorly molecularly characterized, but sub-populations show promising response to immune checkpoint inhibitors. Here, the authors identify a subset of LUSC characterized by infiltration of inflammatory monocytes, wh
Externí odkaz:
https://doaj.org/article/98a06355bdd34530b4587e1a8b9d1ffe
Autor:
Juli R. Bagó, Adolfo Alfonso-Pecchio, Onyi Okolie, Raluca Dumitru, Amanda Rinkenbaugh, Albert S. Baldwin, C. Ryan Miller, Scott T. Magness, Shawn D. Hingtgen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Neural stem cells have a tropism for glioblastoma. Here the authors employ fibroblasts directly reprogrammed into induced neural stem cells and loaded with cytotoxic molecules to migrate to xenotransplanted brain tumours in mice, achieving tumour shr
Externí odkaz:
https://doaj.org/article/b167638618f64960906efb2752744934
Autor:
Jeffrey S. Damrauer, Michael E. Stadler, Swarnali Acharyya, Albert S. Baldwin, Marion E. Couch, Denis C. Guttridge
Publikováno v:
European Journal of Translational Myology, Vol 28, Iss 2 (2018)
A compounding feature of greater than 50% of all cancers is the high incidence of the cachexia syndrome, a complex metabolic disorder characterized by extreme weight loss due mainly to the gross depletion of skeletal muscle tissue. Although studies i
Externí odkaz:
https://doaj.org/article/67b392e706db4aeb90de69444dfa2a11
Publikováno v:
Cells, Vol 7, Iss 9, p 139 (2018)
While primarily studied for their roles in innate immune response, the IκB kinase (IKK)-related kinases TANK-binding kinase 1 (TBK1) and IKKε also promote the oncogenic phenotype in a variety of cancers. Additionally, several substrates of these ki
Externí odkaz:
https://doaj.org/article/e8dbd4d9c21b4a6dbf10b5bad253c0ba
Publikováno v:
Cells, Vol 5, Iss 2, p 16 (2016)
The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune responses. Additionally, aberrant NF-κB signaling has been identified in many types of cancer. Downstream of key oncogenic pathways, such as RAS, BCR-ABL, and
Externí odkaz:
https://doaj.org/article/87495ce84b1d416e9004f01fc712f906
Autor:
Sabrina E. Iskandar, Jarrett M. Pelton, Elizaveta T. Wick, Derek L. Bolhuis, Albert S. Baldwin, Michael J. Emanuele, Nicholas G. Brown, Albert A. Bowers
Publikováno v:
Journal of the American Chemical Society. 145:1512-1517
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::662a991c89b8f21f88273271a19bff4d
https://doi.org/10.1021/jacs.2c11294
https://doi.org/10.1021/jacs.2c11294