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pro vyhledávání: '"Albert Negrete-Hurtado"'
Autor:
Elena Calleja Barca, Elodie De Bruyckere, Natalia L. Kononenko, Santiago Camblor-Perujo, James Adjaye, Soraia Martins, Sujoy Bera, Christoph Wittich, Albert Negrete-Hurtado, Nina Ellrich, Julia Racho
Publikováno v:
EMBO Reports
Cleavage of amyloid precursor protein (APP) by BACE‐1 (β‐site APP cleaving enzyme 1) is the rate‐limiting step in amyloid‐β (Aβ) production and a neuropathological hallmark of Alzheimer's disease (AD). Despite decades of research, mechanis