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Akademický článek

Supervised mutational signatures for obesity and other tissue-specific etiological factors in cancer

Autor: Bahman Afsari, Albert Kuo, YiFan Zhang, Lu Li, Kamel Lahouel, Ludmila Danilova, Alexander Favorov, Thomas A Rosenquist, Arthur P Grollman, Ken W Kinzler, Leslie Cope, Bert Vogelstein, Cristian Tomasetti

Publikováno v: eLife, Vol 10 (2021)

Determining the etiologic basis of the mutations that are responsible for cancer is one of the fundamental challenges in modern cancer research. Different mutational processes induce different types of DNA mutations, providing ‘mutational signature

Externí odkaz: https://doaj.org/article/eb75fd97d7114fa0ba902af179400db3

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Quantification and statistical modeling of droplet-based single-nucleus RNA-sequencing data

Autor: Albert Kuo, Kasper D Hansen, Stephanie C Hicks

Publikováno v: Biostatistics.

Summary In complex tissues containing cells that are difficult to dissociate, single-nucleus RNA-sequencing (snRNA-seq) has become the preferred experimental technology over single-cell RNA-sequencing (scRNA-seq) to measure gene expression. To accura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fa0135edf360885d96bd93954cbe656d
https://doi.org/10.1093/biostatistics/kxad010

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Evaluating the impact of multicancer early detection testing on health and economic outcomes: Toward a decision modeling strategy

Autor: Joseph Lipscomb, Susan Horton, Albert Kuo, Cristian Tomasetti

Publikováno v: Cancer. 128:892-908

Emerging data provide initial support for the concept that a single, minimally invasive liquid biopsy test, performed in conjunction with confirmatory radiologic or other diagnostic testing, when indicated, could be deployed on a broad scale to scree

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2b50fc59444f4a15e0fab26b557f80
https://doi.org/10.1002/cncr.33980

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Quantification and statistical modeling of Chromium-based single-nucleus RNA-sequencing data

Autor: Albert Kuo, Kasper D. Hansen, Stephanie C. Hicks

In complex tissues containing cells that are difficult to dissociate, single-nucleus RNA-sequencing (snRNA-seq) has become the preferred experimental technology over single-cell RNA-sequencing (scRNA-seq) to measure gene expression. To accurately mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3249c50bb265490c70bbfc34bcde4142
https://doi.org/10.1101/2022.05.20.492835

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OA29 Clinical outcomes up to week 48 of filgotinib treatment in an ongoing long-term extension trial of RA patients with inadequate response to methotrexate initially treated with filgotinib or adalimumab during the Phase 3 Parent Trial

Autor: Bernard Combe, Yoshiya Tanaka, Paul Emery, Alena Pechonkina, Albert Kuo, Qi Gong, Katrien Van Beneden, Vijay Rajendran, Hendrik Schulze-Koops

Publikováno v: Rheumatology. 61

Background/Aims The preferential Janus kinase (JAK)-1 inhibitor filgotinib (FIL) is approved for treatment of moderately to severely active RA in Europe and Japan. We assessed efficacy and safety of FIL in patients (pts) with inadequate response to M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::248209ab4d55864543fadbc0f49dd6b1
https://doi.org/10.1093/rheumatology/keac132.029

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