Erythropoietin Receptor (EPOR) Signaling in the Osteoclast Lineage Contributes to EPO-Induced Bone Loss in Mice

Autor: Zamzam Awida, Sahar Hiram-Bab, Almog Bachar, Hussam Saed, Dan Zyc, Anton Gorodov, Nathalie Ben-Califa, Sewar Omari, Jana Omar, Liana Younis, Jennifer Ana Iden, Liad Graniewitz Visacovsky, Ida Gluzman, Tamar Liron, Bitya Raphael-Mizrahi, Albert Kolomansky, Martina Rauner, Ben Wielockx, Yankel Gabet, Drorit Neumann

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 19, p 12051 (2022)

Erythropoietin (EPO) is a pleiotropic cytokine that classically drives erythropoiesis but can also induce bone loss by decreasing bone formation and increasing resorption. Deletion of the EPO receptor (EPOR) on osteoblasts or B cells partially mitiga

Externí odkaz: https://doaj.org/article/fadd650e158c4b2ab96699f84a359a83

Anti-CD20-Mediated B Cell Depletion Is Associated With Bone Preservation in Lymphoma Patients and Bone Mass Increase in Mice

Autor: Albert Kolomansky, Irit Kaye, Nathalie Ben-Califa, Anton Gorodov, Zamzam Awida, Ofer Sadovnic, Maria Ibrahim, Tamar Liron, Sahar Hiram-Bab, Howard S. Oster, Nadav Sarid, Chava Perry, Yankel Gabet, Moshe Mittelman, Drorit Neumann

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

Immunotherapy with anti-CD20-specific antibodies (rituximab), has become the standard of care for B cell lymphoproliferative disorders and many autoimmune diseases. In rheumatological patients the effect of rituximab on bone mass yielded conflicting

Externí odkaz: https://doaj.org/article/8fe13af2d8c84491be39e81d8606f215

Erythropoietin Mediated Bone Loss in Mice Is Dose-Dependent and Mostly Irreversible

Autor: Albert Kolomansky, Sahar Hiram-Bab, Nathalie Ben-Califa, Tamar Liron, Naamit Deshet-Unger, Moshe Mittelman, Howard S. Oster, Martina Rauner, Ben Wielockx, Drorit Neumann, Yankel Gabet

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 11, p 3817 (2020)

Recent studies have demonstrated that erythropoietin (EPO) treatment in mice results in trabecular bone loss. Here, we investigated the dose-response relationship between EPO, hemoglobin (Hgb) and bone loss and examined the reversibility of EPO-induc

Externí odkaz: https://doaj.org/article/a15386e8a4b042f4ac0a0bdbf4c18e9d

Erythropoietin receptor in B cells plays a role in bone remodeling in mice

Autor: Nathalie Ben-Califa, Moshe Mittelman, Martina Rauner, Albert Kolomansky, Maria Ibrahim, Naamit Deshet-Unger, Tamar Liron, Sahar Hiram-Bab, Dafna Gilboa, Yankel Gabet, Howard S. Oster, Anton Gorodov, Zamzam Awida, Drorit Neumann, Ben Wielockx

Publikováno v: Theranostics

Erythropoietin (EPO) is a key regulator of erythropoiesis. However, EPO receptors (EPO-Rs) are also expressed on non-erythroid cell types, including myeloid and bone cells. Immune cells also participate in bone homeostasis. B cells produce receptor a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf2020edc4f686c3f8d1398eeaa636c
https://doi.org/10.7150/thno.45845

A predictive algorithm using clinical and laboratory parameters may assist in ruling out and in diagnosing MDS

Autor: Ioannis Kotsianidis, Theo de Witte, Bander Abu Shrkihe, Mette Holm, Pierre Fenaux, Corine van Marrewijk, Albert Kolomansky, Guillermo Sanz, Eva Hellström-Lindberg, Alexandra Smith, Jaroslav Cermak, Dominic Culligan, Argiris Symeonidis, Juliet Mills, David T. Bowen, Saskia Langemeijer, Ulrich Germing, Moshe Mittelman, Simon Crouch, Shoham Baruch, Ge Yu, Howard S. Oster, Laurence Sanhes, Reinhard Stauder, Agnès Guerci-Bresler, Luca Malcovati, Shachar Naor, Krzysztof Madry, Jonathan Ben-Ezra

Publikováno v: Blood Advances
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Blood Advances, 5, 3066-3075
Blood Advances, 5, 16, pp. 3066-3075
Blood Adv
Oster, H S, Crouch, S, Smith, A, Yu, G, Shrkihe, B A, Baruch, S, Kolomansky, A, Ben-Ezra, J, Naor, S, Fenaux, P, Symeonidis, A, Stauder, R, Cermak, J, Sanz, G, Hellstrom-Lindberg, E, Malcovati, L, Langemeijer, S, Germing, U, Holm, M S, Madry, K, Guerci-Bresler, A, Culligan, D, Sanhes, L, Mills, J, Kotsianidis, I, Van Marrewijk, C, Bowen, D, De Witte, T & Mittelman, M 2021, ' A predictive algorithm using clinical and laboratory parameters may assist in ruling out and in diagnosing MDS ', Blood Advances, vol. 5, no. 16, pp. 3066-3075 . https://doi.org/10.1182/bloodadvances.2020004055

Contains fulltext : 237720.pdf (Publisher’s version ) (Open Access) We present a noninvasive Web-based app to help exclude or diagnose myelodysplastic syndrome (MDS), a bone marrow (BM) disorder with cytopenias and leukemic risk, diagnosed by BM ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94b7e20d54f6e4df735596e0eb528ce7
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=14761