Zobrazeno 1 - 10
of 506
pro vyhledávání: '"Albert K. Groen"'
Autor:
Annika Wahlström, Ömrüm Aydin, Lisa M. Olsson, Wilhelm Sjöland, Marcus Henricsson, Annika Lundqvist, Hanns-Ulrich Marschall, Rutger Franken, Arnold van de Laar, Victor Gerdes, Abraham S. Meijnikman, Dag Hofsø, Albert K. Groen, Jøran Hjelmesæth, Max Nieuwdorp, Fredrik Bäckhed
Publikováno v:
EBioMedicine, Vol 106, Iss , Pp 105265- (2024)
Summary: Background: Bariatric surgery is an effective treatment option for obesity and provides long-term weight loss and positive effects on metabolism, but the underlying mechanisms are poorly understood. Alterations in bile acid metabolism have b
Externí odkaz:
https://doaj.org/article/64840ca30a314f63b2613355386bee20
Autor:
Ville T. Männistö, Dorota Kaminska, Sylke Haal, Juho Asteljoki, Panu K. Luukkonen, Pirjo Käkelä, Federica Tavaglione, Michel van Weeghel, Mikko Neuvonen, Mikko Niemi, Stefano Romeo, Max Nieuwdorp, Jussi Pihlajamäki, Albert K. Groen
Publikováno v:
Gastro Hep Advances, Vol 3, Iss 5, Pp 594-601 (2024)
Background and Aims: Gallstone disease (GSD) associates with significant morbidity and mortality. Decreased secretion of bile acids has been suggested as a driving factor for GSD. Recently, we linked the protein phosphatase 1 regulatory subunit 3 bet
Externí odkaz:
https://doaj.org/article/7c50f06b369c41d088bab1ac22b8f9fd
Autor:
Shauna D. O’Donovan, Milena Rundle, E. Louise Thomas, Jimmy D. Bell, Gary Frost, Doris M. Jacobs, Anne Wanders, Ryan de Vries, Edwin C.M. Mariman, Marleen A. van Baak, Luc Sterkman, Max Nieuwdorp, Albert K. Groen, Ilja C.W. Arts, Natal A.W. van Riel, Lydia A. Afman
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109362- (2024)
Summary: The manifestation of metabolic deteriorations that accompany overweight and obesity can differ greatly between individuals, giving rise to a highly heterogeneous population. This inter-individual variation can impede both the provision and a
Externí odkaz:
https://doaj.org/article/1afe869749f64bceae5d59aec0da226c
Autor:
Moritz V. Warmbrunn, Harsh Bahrar, Nicolien C. de Clercq, Annefleur M. Koopen, Pieter F. de Groot, Joost Rutten, Leo A. B. Joosten, Ruud S. Kootte, Kristien E. C. Bouter, Kasper W. ter Horst, Annick V. Hartstra, Mireille J. Serlie, Maarten R. Soeters, Daniel H. van Raalte, Mark Davids, Evgeni Levin, Hilde Herrema, Niels P. Riksen, Mihai G. Netea, Albert K. Groen, Max Nieuwdorp
Publikováno v:
Nutrients, Vol 16, Iss 12, p 1822 (2024)
Context/Objective: In order to better understand which metabolic differences are related to insulin resistance in metabolic syndrome (MetSyn), we used hyperinsulinemic–euglycemic (HE) clamps in individuals with MetSyn and related peripheral insulin
Externí odkaz:
https://doaj.org/article/c9a5b2be04634c13a2be6bcf5a19df26
Autor:
Vehpi Yildirim, Kasper W. ter Horst, Pim W. Gilijamse, Dewi van Harskamp, Henk Schierbeek, Hans Jansen, Alinda W.M. Schimmel, Max Nieuwdorp, Albert K. Groen, Mireille J. Serlie, Natal A.W. van Riel, Geesje M. Dallinga-Thie
Publikováno v:
JCI Insight, Vol 8, Iss 16 (2023)
Dyslipidemia in obesity results from excessive production and impaired clearance of triglyceride-rich (TG-rich) lipoproteins, which are particularly pronounced in the postprandial state. Here, we investigated the impact of Roux-en-Y gastric bypass (R
Externí odkaz:
https://doaj.org/article/0f159909912c460780398d2a0da730af
Autor:
Ilias Attaye, Pierre Bel Lassen, Solia Adriouch, Emilie Steinbach, Rafael Patiño-Navarrete, Mark Davids, Rohia Alili, Flavien Jacques, Sara Benzeguir, Eugeni Belda, Ina Nemet, James T. Anderson, Laure Alexandre-Heymann, Arno Greyling, Etienne Larger, Stanley L. Hazen, Sophie L. van Oppenraaij, Valentina Tremaroli, Katharina Beck, Per-Olof Bergh, Fredrik Bäckhed, Suzan P.M. ten Brincke, Hilde Herrema, Albert K. Groen, Sara-Joan Pinto-Sietsma, Karine Clément, Max Nieuwdorp
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107471- (2023)
Summary: High-protein diets are promoted for individuals with type 2 diabetes (T2D). However, effects of dietary protein interventions on (gut-derived) metabolites in T2D remains understudied. We therefore performed a multi-center, randomized-control
Externí odkaz:
https://doaj.org/article/0078ac92a6de49509fac4a5b45e06330
Autor:
Guido J. Bakker, Abraham S. Meijnikman, Torsten P. Scheithauer, Mark Davids, Ömrüm Aydin, Thomas C. C. Boerlage, L. Maurits deBrauw, Arnold W. van deLaar, Victor E. Gerdes, Albert K. Groen, Daniël H. vanRaalte, Hilde Herrema, Max Nieuwdorp
Publikováno v:
Obesity Science & Practice, Vol 8, Iss 1, Pp 56-65 (2022)
Abstract Aims Visceral adipose tissue inflammation is a fundamental mechanism of insulin resistance in obesity and type 2 diabetes. Translocation of intestinal bacteria has been suggested as a driving factor for the inflammation. However, although ba
Externí odkaz:
https://doaj.org/article/8634882a32a6483e959e0f2d98ad71e1
Autor:
Maaike Blankestijn, Vincent W. Bloks, Dicky Struik, Nicolette Huijkman, Niels Kloosterhuis, Justina C. Wolters, Ronald J. A. Wanders, Frédéric M. Vaz, Markus Islinger, Folkert Kuipers, Bart van de Sluis, Albert K. Groen, Henkjan J. Verkade, Johan W. Jonker
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Peroxisomes play an important role in the metabolism of a variety of biomolecules, including lipids and bile acids. Peroxisomal Membrane Protein 4 (PXMP4) is a ubiquitously expressed peroxisomal membrane protein that is transcriptionally reg
Externí odkaz:
https://doaj.org/article/4641e716dcdd48d6b1399eb16d2429df
Autor:
Dimitra Lappa, Abraham S. Meijnikman, Kimberly A. Krautkramer, Lisa M. Olsson, Ömrüm Aydin, Anne-Sophie Van Rijswijk, Yair I. Z. Acherman, Maurits L. De Brauw, Valentina Tremaroli, Louise E. Olofsson, Annika Lundqvist, Siv A. Hjorth, Boyang Ji, Victor E. A. Gerdes, Albert K. Groen, Thue W. Schwartz, Max Nieuwdorp, Fredrik Bäckhed, Jens Nielsen
Publikováno v:
PLoS ONE, Vol 18, Iss 3 (2023)
Weight loss through bariatric surgery is efficient for treatment or prevention of obesity related diseases such as type 2 diabetes and cardiovascular disease. Long term weight loss response does, however, vary among patients undergoing surgery. Thus,
Externí odkaz:
https://doaj.org/article/ff98972c69364e71830211bcfa198324
Autor:
Shiqi Zhong, Raphael Chèvre, David Castaño Mayan, Maria Corlianò, Blake J. Cochran, Kai Ping Sem, Theo H. van Dijk, Jianhe Peng, Liang Juin Tan, Siddesh V. Hartimath, Boominathan Ramasamy, Peter Cheng, Albert K. Groen, Folkert Kuipers, Julian L. Goggi, Chester Drum, Rob M. van Dam, Ru San Tan, Kerry-Anne Rye, Michael R. Hayden, Ching-Yu Cheng, Shaji Chacko, Jason Flannick, Xueling Sim, Hong Chang Tan, Roshni R. Singaraja
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 21 (2022)
BACKGROUND Cytochrome P450 family 8 subfamily B member 1 (CYP8B1) generates 12α-hydroxylated bile acids (BAs) that are associated with insulin resistance in humans.METHODS To determine whether reduced CYP8B1 activity improves insulin sensitivity, we
Externí odkaz:
https://doaj.org/article/d03f46bd050f440897a9444be497521e