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pro vyhledávání: '"Albert John Molinari"'
Autor:
John Considine, William DeMaio, Eugene John Trybulski, Kadum Ali, Jian Qi, David Cochran, Lynne Lihotz, Albert John Molinari, Jehan F. Bagli, Susan Christman Croce
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(21)
Small molecule agonists and antagonists of the V(2)-vasopressin receptor have been discovered and have undergone clinical trials. In conjunction with these discovery programs, the synthesis and biological testing of various metabolites associated wit
Autor:
Jehan F. Bagli, Albert John Molinari, Mark A. Ashwell, Eugene J. Trybulski, Mary M. Sherman, C.H. Park, C Palka, J.F Rogers, Thomas J. Caggiano, David K. Williams, Peter S. Chan
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(8)
Ionizable groups were introduced onto the 10,11-dihydro-5 H -pyrrolo[2,1- c ][1,4]benzodiazepine scaffold of the vasopressin V 2 -antagonist WAY-VPA-985 in the search for molecules optimized for parenteral formulation. The synthesis and structure–a