Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Albert Jaxa-Chamiec"'
Autor:
Sandra Sacre, Albert Jaxa-Chamiec, Caroline M. R. Low, Giselle Chamberlain, Cathy Tralau-Stewart
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Antidepressants are increasingly recognized to have anti-inflammatory properties in addition to their ability to treat major depressive disorders. To explore if engagement of 5-hydroxytryptamine (5-HT) receptors was required for the anti-inflammatory
Externí odkaz:
https://doaj.org/article/e03023c2da2f45bea40af4e459cb2710
Autor:
Peter Cherepanov, Stephen Hare, Mathieu Métifiot, Albert Jaxa-Chamiec, Steven J. Smith, Yves Pommier, Stephen H. Hughes
Publikováno v:
Molecular Pharmacology. 80:565-572
Raltegravir (RAL) and related HIV-1 integrase (IN) strand transfer inhibitors (INSTIs) efficiently block viral replication in vitro and suppress viremia in patients. These small molecules bind to the IN active site, causing it to disengage from the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f94220b25e78a34e6d5eb89428f544b
https://doi.org/10.1124/mol.111.073189
https://doi.org/10.1124/mol.111.073189
Autor:
Laura Tornatore, Annamaria Sandomenico, Domenico Raimondo, Caroline Low, Alberto Rocci, Cathy Tralau-Stewart, Daria Capece, Daniel D’Andrea, Marco Bua, Eileen Boyle, Mark van Duin, Pietro Zoppoli, Albert Jaxa-Chamiec, Anil K. Thotakura, Julian Dyson, Brian A. Walker, Antonio Leonardi, Angela Chambery, Christoph Driessen, Pieter Sonneveld, Gareth Morgan, Antonio Palumbo, Anna Tramontano, Amin Rahemtulla, Menotti Ruvo, Guido Franzoso
Publikováno v:
Cancer Cell
Summary Constitutive NF-κB signaling promotes survival in multiple myeloma (MM) and other cancers; however, current NF-κB-targeting strategies lack cancer cell specificity. Here, we identify the interaction between the NF-κB-regulated antiapoptoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa807c597b910aa2661eb68d64a833f3
Autor:
Gavin A.C. Chung, Paul W. Smith, Mike R. Wood, Ken Duncan, Albert Jaxa Chamiec, Peter D. Howes, Andrew R. Whittington, Kevin N. Cobley
Publikováno v:
The Journal of Antibiotics. 48:73-82
A series of cephalosporins containing a novel 7-[2-(Z)-(2-amino-thiazol-4- yl)-3-(dimethoxy-phosphoryl)-acryloylamino] group were prepared and their antibacterial activity measured against a range of pathogens. In general the compounds displayed a br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3cf8f8e3b73e0a759a971665d1308c0
https://doi.org/10.7164/antibiotics.48.73
https://doi.org/10.7164/antibiotics.48.73
Autor:
FRANZOSO GUIDO, TORNATORE LAURA, ALBERT JAXA-CHAMIEC, SIMONA M. MONTI, CAROLINE LOW, CATHERINE TRALAU-STEWART, MENOTTI RUVO
Publikováno v:
PCT/GB2010/001970, Internazionale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=cnr_________::955bdb5b53827223544277d57caea1ff
http://www.cnr.it/prodotto/i/144484
http://www.cnr.it/prodotto/i/144484
Autor:
Katherine A. Scott, Albert Jaxa-Chamiec, Hayley C. Cordingley, Kathryn L. Chapman, Katie E. Judd, James C. Collins, Catherine Tralau-Stewart, David J. Mann, Alan Armstrong, Caroline M. R. Low
Publikováno v:
MedChemComm. 4:1148
A series of novel reversible inhibitors of the dual-specificity phosphatase Cdc25 was discovered using a two-stage molecular field-based similarity analysis. This method compares molecules on the basis of electrostatic and steric features, rather tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::288d632df36b142fddfb7cf7dcc49658
https://doi.org/10.1039/c3md00047h
https://doi.org/10.1039/c3md00047h
Autor:
Richard Cosstick, A. Stanley Jones, Colin Picton, Albert Jaxa Chamiec, Iain S. Sim, Richard T. Walker
Publikováno v:
Nucleosides and Nucleotides. 7:129-135
A series of 5′-substituted-deoxypyrimidine nucleosides were examined for their ability to inhibit the thymidine kinases of types 1 and 2 herpes simplex virus; structure activity relationships were determined.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b98dba61e657a624d3a0f123926185fb
https://doi.org/10.1080/07328318808070197
https://doi.org/10.1080/07328318808070197