Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Albert J. Robichaud"'
Publikováno v:
ARKIVOC, Vol 2010, Iss 6, Pp 84-88 (2009)
Externí odkaz:
https://doaj.org/article/33c9eb10d3054a7e970878457fcb261c
Autor:
Matthew D. Hill, Maria-Jesus Blanco, Francesco G. Salituro, Zhu Bai, Jacob T. Beckley, Michael A. Ackley, Jing Dai, James J. Doherty, Boyd L. Harrison, Ethan C. Hoffmann, Tatiana M. Kazdoba, David Lanzetta, Michael Lewis, Michael C. Quirk, Albert J. Robichaud
Publikováno v:
Journal of Medicinal Chemistry. 65:9063-9075
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55c17424c1aec1450e3aa6abf75d1774
https://doi.org/10.1021/acs.jmedchem.2c00313
https://doi.org/10.1021/acs.jmedchem.2c00313
Autor:
Weiting Tang, Jacob T. Beckley, Jin Zhang, Rui Song, Yuchen Xu, Sukhan Kim, Michael C. Quirk, Albert J. Robichaud, Eva Sarai Diaz, Scott J. Myers, James J. Doherty, Michael A. Ackley, Stephen F. Traynelis, Hongjie Yuan
Publikováno v:
Cellular and Molecular Life Sciences. 80
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb1cf9a994a2f634cf6cecdf91ce7fd4
https://doi.org/10.1007/s00018-022-04667-7
https://doi.org/10.1007/s00018-022-04667-7
Autor:
James J. Doherty, Michael A. Ackley, Ethan Hoffmann, Tatiana M. Kazdoba, Zhu Bai, Boyd L. Harrison, Albert J. Robichaud, Andrew Griffin, Mike Lewis, Gabriel Martinez Botella, Francesco G. Salituro, Daniel S. La, Jing Dai, Michael Quirk
Publikováno v:
Journal of Medicinal Chemistry. 62:7526-7542
Neuroactive steroids (NASs) play a pivotal role in maintaining homeostasis is the CNS. We have discovered that one NAS in particular, 24(S)-hydroxycholesterol (24(S)-HC), is a positive allosteric modulator (PAM) of NMDA receptors. Using 24(S)-HC as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d85c93f6e01f9e02e46c0fd48ba0202c
https://doi.org/10.1021/acs.jmedchem.9b00591
https://doi.org/10.1021/acs.jmedchem.9b00591
Autor:
Francesco G. Salituro, Gabriel Martinez Botella, James J. Doherty, Rebecca S. Hammond, Alison L. Althaus, Carla Maciag, Albert J. Robichaud, Michael A. Ackley
Publikováno v:
Epilepsy Research. 134:16-25
Despite the availability of multiple antiepileptic drugs (AED), failure to adequately control seizures is a challenge for approximately one third of epilepsy patients, and new therapies with a differentiated mechanism of action are needed. The neuroa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2ebdf33e1a2544115114f31f08ce039
https://doi.org/10.1016/j.eplepsyres.2017.05.001
https://doi.org/10.1016/j.eplepsyres.2017.05.001
Autor:
Ethan Hoffman, Cecelia E. Jackson, James J. Doherty, John H. McDonough, Carl D. Smith, Albert J. Robichaud, Hilary S. McCarren, Alison L. Althaus, Aymen Alqazzaz, Rebecca S. Hammond
Publikováno v:
Epilepsy & Behavior. 68:22-30
Organophosphorus nerve agents (OPNAs) are irreversible inhibitors of acetylcholinesterase that pose a serious threat to public health because of their use as chemical weapons. Exposure to high doses of OPNAs can dramatically potentiate cholinergic sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d874169c0e40070626c865b31540039
https://doi.org/10.1016/j.yebeh.2016.12.024
https://doi.org/10.1016/j.yebeh.2016.12.024
Autor:
Daniel S, La, Francesco G, Salituro, Gabriel, Martinez Botella, Andrew M, Griffin, Zhu, Bai, Michael A, Ackley, Jing, Dai, James J, Doherty, Boyd L, Harrison, Ethan C, Hoffmann, Tatiana M, Kazdoba, Michael C, Lewis, Michael C, Quirk, Albert J, Robichaud
Publikováno v:
Journal of medicinal chemistry. 62(16)
Neuroactive steroids (NASs) play a pivotal role in maintaining homeostasis is the CNS. We have discovered that one NAS in particular, 24(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8edd1a5945ab2bc16424985f2d7c6fb6
https://pubmed.ncbi.nlm.nih.gov/31390523
https://pubmed.ncbi.nlm.nih.gov/31390523
Autor:
Paul Davies, Albert J. Robichaud, Ethan Hoffmann, James J. Doherty, Tatiana M. Kazdoba, Amit Modgil, Steven M. Gee, Stephen J. Moss, Rebecca S. Hammond, Gabriel M. Belfort, Alison L. Althaus, David P. Nguyen, Jing Dai, Michael Quirk, Francesco G. Salituro, Michael A. Ackley
Publikováno v:
Neuropharmacology. 181:108333
Zuranolone (SAGE-217) is a novel, synthetic, clinical stage neuroactive steroid GABAA receptor positive allosteric modulator designed with the pharmacokinetic properties to support oral daily dosing. In vitro, zuranolone enhanced GABAA receptor curre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99890c8b94a6266c6c6c30159fa25bcf
https://doi.org/10.1016/j.neuropharm.2020.108333
https://doi.org/10.1016/j.neuropharm.2020.108333
Autor:
James J. Doherty, Y. Ueyama, Gabriel M. Belfort, Albert J. Robichaud, W.W. Muir, Jing Dai, Francesco G. Salituro, B.L. Youngblood, R.H. Hammond
Publikováno v:
Journal of neuroscience methods. 305
Background Different levels of consciousness are required in order to perform different medical procedures. Sedation scales established to objectively define various levels of sedation in humans have not been thoroughly characterized in non-human spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f160f4a7bb8d81962d33da8d3579869
https://pubmed.ncbi.nlm.nih.gov/29772269
https://pubmed.ncbi.nlm.nih.gov/29772269
Autor:
Zhu Bai, Scott J. Grossman, Jiamiao Wang, Richard Thomas Beresis, Ethan Hoffmann, Gabriel Martinez Botella, Carlos M. Loya, Kaisheng Shen, Francesco G. Salituro, Albert J. Robichaud, Boyd L. Harrison, Michael A. Ackley, Shiling Jia, Gabriel M. Belfort, James J. Doherty
Publikováno v:
Journal of Medicinal Chemistry. 58:3500-3511
Neuroactive steroids (NASs) have been shown to impact central nervous system (CNS) function through positive allosteric modulation of the GABA(A) receptor (GABA(A)-R). Herein we report the effects on the activity and pharmacokinetic properties of a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::526fcbe06be37d20a154344dc5f6e61e
https://doi.org/10.1021/acs.jmedchem.5b00032
https://doi.org/10.1021/acs.jmedchem.5b00032