Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Albert J. Mura"'
Autor:
Dennis J. Hlasta, Dunlap Richard Paul, Ranjit C. Desai, Jian Shen, Catherine A. Franke, John J. Court, Timothy G. Talomie, Albert J. Mura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2941-2946
Distinct differences in the SAR for HLE and PPE inhibition in this class of compounds were observed. For example, larger lipophilic substituents at the benzisothiazolone 4-position afforded inhibitors that were potent against HLE, but inactive agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::711bb7085e99a1a2abd047658bc4eb09
https://doi.org/10.1016/s0960-894x(96)00553-7
https://doi.org/10.1016/s0960-894x(96)00553-7
Autor:
Virendra Kumar, Malcolm R. Bell, Arup K. Ghose, Catherine A. Franke, Albert J. Mura, Dunlap Richard Paul, Chakrapani Subramanyam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:325-330
Potent mechanism based inhibition of human leukocyte elastase (HLE) by tetrahydrobenzisothiazolones ( 2 ) is described. Structure activity relationships studies led to the identification of WIN 62816 ( 2c ), the most potent inhibitor in this series w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e3510b7945951cca9da8aa953256dab
https://doi.org/10.1016/0960-894x(95)00029-s
https://doi.org/10.1016/0960-894x(95)00029-s
Autor:
Robert G. Gordon, Albert J. Mura, Edward Ferguson, Malcolm R. Bell, Dunlap Richard Paul, Catherine A. Franke, Chakrapani Subramanyam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:319-324
A series of 4-isopropyl benzisothiazolinylmethyl aryl ethers were prepared and evaluated as inhibitors of human leukocyte elastase (HLE). Among the phenols attached as leaving groups onto N-methyl of the 4-isopropyl benzisothiazolone nucleus, the sul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b99c537ff959f3a951328b41b6cf0c7
https://doi.org/10.1016/0960-894x(95)00028-r
https://doi.org/10.1016/0960-894x(95)00028-r
Autor:
Sandhya Subramanian, Virendra Kumar, Catherine A. Franke, Dunlap Richard Paul, Dennis J. Hlasta, Malcolm R. Bell, Edward Ferguson, Anne G. Rowlands, Judith A. Johnson, John J. Court, David Robinson, Manohar Saindane, Marion L. Drozd, Chakrapani Subramanyam, Alan L. Maycock, Karl R. Mueller, W. Mark Eickhoff, Paul J. Silver, Albert J. Mura, Edward D. Pagani, Robert J. Gordon, Ranjit C. Desai, Philip M. Carabateas
Publikováno v:
Journal of medicinal chemistry. 38(5)
Human leukocyte elastase (HLE) has been proposed as a primary mediator of pulmonary emphysema and other inflammatory airway diseases. HLE is capable of cleaving many proteins, including elastin, other components of connective tissue, certain compleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd72bd054d626ee601414321d310026
https://pubmed.ncbi.nlm.nih.gov/7877139
https://pubmed.ncbi.nlm.nih.gov/7877139
Publikováno v:
Tetrahedron Letters. 16:4437-4440
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15a8d6aaea1165ccffd73cb8e73f804a
https://doi.org/10.1016/s0040-4039(00)91086-4
https://doi.org/10.1016/s0040-4039(00)91086-4
Publikováno v:
Tetrahedron Letters. 16:4433-4436
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d921b048fc95686adbde1f252321309c
https://doi.org/10.1016/s0040-4039(00)91085-2
https://doi.org/10.1016/s0040-4039(00)91085-2
Publikováno v:
The Journal of Organic Chemistry. 40:812-813
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d941f58f75369373ec4b7829dde619c
https://doi.org/10.1021/jo00894a038
https://doi.org/10.1021/jo00894a038
Publikováno v:
The Journal of Organic Chemistry. 41:2506-2507
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9a2752061d824e683cf644f7648358e
https://doi.org/10.1021/jo00876a041
https://doi.org/10.1021/jo00876a041
Autor:
Albert J. Mura, Elaine R. Fogel, Theodore Cohen, J. R. Falck, Robert J. Ruffner, David W. Shull
Publikováno v:
The Journal of Organic Chemistry. 41:3218-3219
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc2593c66d1b349276eff0de5e682051
https://doi.org/10.1021/jo00881a041
https://doi.org/10.1021/jo00881a041
Publikováno v:
The Journal of Organic Chemistry. 40:3810-3810
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ed6d679a49db56c796f1f6e63bbd801
https://doi.org/10.1021/jo00913a610
https://doi.org/10.1021/jo00913a610