Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Albert J. Azzaro"'
Autor:
Kimberly Blanchard Portland, Melissa P. DelBello, Arif Khan, Graham J. Emslie, Albert J. Azzaro, Alain Katic, Thomas J. Hochadel
Publikováno v:
Journal of Child and Adolescent Psychopharmacology. 24:311-317
A randomized, double-blind, placebo-controlled flexible-dose, parallel group trial was conducted at 26 clinical investigational sites in the United States to examine the safety and efficacy of the selegiline transdermal system (STS) (EMSAM®) in adol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e609a50cc4cfa07dfe5ae71514a637c7
https://doi.org/10.1089/cap.2013.0138
https://doi.org/10.1089/cap.2013.0138
Publikováno v:
Clinical Pharmacology in Drug Development. 3:4-12
This Phase 1, single-center, double-blind, placebo-controlled, three-period study assessed cardiovascular safety of CX157, a specific Reversible Inhibitor of Monoamine Oxidase A (RIMA), following the oral administration of tyramine. In Period 1, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3bd8b8e415838d040dd947bedb2e08ef
https://doi.org/10.1002/cpdd.61
https://doi.org/10.1002/cpdd.61
Autor:
Chad M. VanDenBerg, Lawrence F. Blob, Albert J. Azzaro, Bryan J. Campbell, Eva M. Kemper, John Ziemniak
Publikováno v:
The Journal of Clinical Pharmacology. 47:978-990
Selegiline transdermal system is a recently approved monoamine oxidase inhibitor antidepressant. Medications that inhibit monoamine oxidase type A can augment the pressor effects of sympathomimetic amines, increasing the potential for hypertensive cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea8dc55543660d932dc7f02b090ce3a
https://doi.org/10.1177/0091270007302950
https://doi.org/10.1177/0091270007302950
Publikováno v:
The Journal of Clinical Pharmacology. 47:146-158
Selegiline transdermal system (STS) is a recently approved monoamine oxidase inhibitor antidepressant. This article reports results from 3 studies examining the potential for cytochrome P450-dependent pharmacokinetic interactions between STS and 3 ps
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58bde23b6b784b86ad85721479998142
https://doi.org/10.1177/0091270006296151
https://doi.org/10.1177/0091270006296151
Publikováno v:
Journal of Toxicology: Cutaneous and Ocular Toxicology. 23:173-178
Two preclinical sensitization studies were conducted to determine the potential for allergic contact dermatitis with the selegiline transdermal system (STS), a novel transdermal system being developed to treat major depressive disorder. These include
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a5eb9b37129f4057452542c718d4f99
https://doi.org/10.1081/cus-200035363
https://doi.org/10.1081/cus-200035363
Publikováno v:
Journal of Clinical Pharmacology. 43:604-609
Tyramine challenge studies have demonstrated that it requires approximately twice the amount of tyramine administered with a meal compared to administration after a fast to elicit the same effect, suggesting a reduction in bioavailability of tyramine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7335e47176149648947e665522d73fec
https://doi.org/10.1177/0091270003043006006
https://doi.org/10.1177/0091270003043006006
Autor:
Dennis Cole, Virgilio Centenera, Emmanuel Schenkman, Anne Johnson, Albert J. Azzaro, Julie Kim, Michael G. Mawhinney, John P. Durham
Publikováno v:
Journal of Urology. 167:1897-1904
Guinea pig seminal vesicle smooth muscle displays an initial androgen dependent, proliferative response during early puberty, followed by progression to an androgen resistant, amitotic state in adults. We determined the role of norepinephrine in andr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de79a137cc82e14b5e9c833a7a7134ed
https://doi.org/10.1016/s0022-5347(05)65257-3
https://doi.org/10.1016/s0022-5347(05)65257-3
Autor:
Lynn Wecker, Kathleen A. Sherman, Christopher D Muller, Albert J. Azzaro, Marcia N. Gordon, David G. Morgan
Publikováno v:
Pharmacology Biochemistry and Behavior. 63:501-506
These studies compared the dose-response effects of oral vs. transdermal selegiline on antidepressant-like activity and brain monoamine oxidase (MAO) activities in rats. Rats received selegiline by gavage (0-100 mg/kg) or via transdermal patches (0-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c402e77877d56a3562655e8c9235b85
https://doi.org/10.1016/s0091-3057(99)00016-7
https://doi.org/10.1016/s0091-3057(99)00016-7
Autor:
A.R. Disanto, Thomas J. Hochadel, Richard J. Morales, Jeffrey S. Barrett, John Darnow, Shashank Rohatagi, Albert J. Azzaro, Sara K. Watson, Kimberly E. DeWitt
Publikováno v:
The Journal of Clinical Pharmacology. 37:238-247
Orally administered selegiline hydrochloride is a selective monoamine oxidase type B inhibitor at the recommended regimen of 10 mg/day, but it loses selectivity at higher doses. In bypassing first-pass metabolism, a 24-hour application of transdermal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9fd22f3389e7b57c419b09f6aa1b331
https://doi.org/10.1002/j.1552-4604.1997.tb04786.x
https://doi.org/10.1002/j.1552-4604.1997.tb04786.x
Publikováno v:
Neuroendocrinology. 62:333-339
The role of the amygdala in the regulation of hypothalamic release of corticotropin-releasing factor (CRF) was investigated. Microinjection of glutamate (50 nmol) into the amygdala resulted in increased plasma corticosterone in male rats previously s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763ce39b032a296ac13d613b5407c586
https://doi.org/10.1159/000127022
https://doi.org/10.1159/000127022