Zobrazeno 1 - 10
of 628
pro vyhledávání: '"Albert J R Heck"'
Autor:
Miranda P Dierselhuis, Maaike Nederend, Jeanette H W Leusen, Mitchell Evers, Marco Jansen, Chilam Chan, Thomas Valerius, Friederike Meyer-Wentrup, Annelisa M Cornel, Marjolein C Stip, Karli R Reiding, Mirjam J Damen, Albert J R Heck, Sofia Koustoulidou, Ruud Ramakers, Gerard C Krijger, Remmert de Roos, Edouard Souteyrand, Mark de Boer, Geert van Tetering
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 7 (2023)
Background Immunotherapy targeting GD2 is very effective against high-risk neuroblastoma, though administration of anti-GD2 antibodies induces severe and dose-limiting neuropathic pain by binding GD2-expressing sensory neurons. Previously, the IgG1 c
Externí odkaz:
https://doaj.org/article/91ef00d451c44452a3b035076288a7e9
Autor:
Sietske Kooijman, Jolanda Brummelman, Cécile A C M van Els, Fabio Marino, Albert J R Heck, Elly van Riet, Bernard Metz, Gideon F A Kersten, Jeroen L A Pennings, Hugo D Meiring
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197885 (2018)
Aluminum-based adjuvants have widely been used in human vaccines since 1926. In the absence of antigens, aluminum-based adjuvants can initiate the inflammatory preparedness of innate cells, yet the impact of antigens on this response has not been inv
Externí odkaz:
https://doaj.org/article/6ad0b8e6c56a4ef89898621dfb1da13b
Autor:
Tokameh Mahmoudi, Sylvia F Boj, Pantelis Hatzis, Vivian S W Li, Nadia Taouatas, Robert G J Vries, Hans Teunissen, Harry Begthel, Jeroen Korving, Shabaz Mohammed, Albert J R Heck, Hans Clevers
Publikováno v:
PLoS Biology, Vol 15, Iss 2, p e1002596 (2017)
[This corrects the article DOI: 10.1371/journal.pbio.1000539.].
Externí odkaz:
https://doaj.org/article/62c1db93ed6448449dcd4f427ae3ddea
Autor:
Amila Zuko, Asami Oguro-Ando, Harm Post, Renske L.R.E. Taggenbrock, Roland E. van Dijk, Maarten Altelaar, Albert J R Heck, Alexander G Petrenko, Bert van der Zwaag, Yasushi Shimoda, R. Jeroen Pasterkamp, J. Peter H. Burbach
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 9 (2016)
In view of important neurobiological functions of the cell adhesion molecule contactin-6 (Cntn6) that have emerged from studies on null-mutant mice and autism spectrum disorders (ASD) patients, we set out to examine pathways underlying functions of C
Externí odkaz:
https://doaj.org/article/c6bf140738f3416cb64bb637ae7ca4b6
Autor:
Vincent Portegijs, Lars-Eric Fielmich, Matilde Galli, Ruben Schmidt, Javier Muñoz, Tim van Mourik, Anna Akhmanova, Albert J R Heck, Mike Boxem, Sander van den Heuvel
Publikováno v:
PLoS Genetics, Vol 12, Iss 10, p e1006291 (2016)
During cell division, the mitotic spindle segregates replicated chromosomes to opposite poles of the cell, while the position of the spindle determines the plane of cleavage. Spindle positioning and chromosome segregation depend on pulling forces on
Externí odkaz:
https://doaj.org/article/65b4e9471ec84fcebdab820d5774c799
Autor:
Rob N de Jong, Frank J Beurskens, Sandra Verploegen, Kristin Strumane, Muriel D van Kampen, Marleen Voorhorst, Wendy Horstman, Patrick J Engelberts, Simone C Oostindie, Guanbo Wang, Albert J R Heck, Janine Schuurman, Paul W H I Parren
Publikováno v:
PLoS Biology, Vol 14, Iss 1, p e1002344 (2016)
IgG antibodies can organize into ordered hexamers on cell surfaces after binding their antigen. These hexamers bind the first component of complement C1 inducing complement-dependent target cell killing. Here, we translated this natural concept into
Externí odkaz:
https://doaj.org/article/bfabba60d9884594bbcd39074b399b29
Autor:
Siddarth Soni, Antonia J A Raaijmakers, Linsey M Raaijmakers, J Mirjam A Damen, Leonie van Stuijvenberg, Marc A Vos, Albert J R Heck, Toon A B van Veen, Arjen Scholten
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0152231 (2016)
AIMS:Synchronous beating of the heart is dependent on the efficient functioning of the cardiac intercalated disk (ID). The ID is composed of a complex protein network enabling electrical continuity and chemical communication between individual cardio
Externí odkaz:
https://doaj.org/article/0b7a0274d6d84bf1b6e6b9b5692925bf
Autor:
Saurabh K Srivastava, Vincent J B Ruigrok, Natalie J Thompson, Anke K Trilling, Albert J R Heck, Cees van Rijn, Jules Beekwilder, Maarten A Jongsma
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64040 (2013)
BACKGROUND: The 16 kDa heat shock protein (HSP) is an immuno-dominant antigen, used in diagnosis of infectious Mycobacterium tuberculosis (M.tb.) causing tuberculosis (TB). Its use in serum-based diagnostics is limited, but for the direct identificat
Externí odkaz:
https://doaj.org/article/0dd5c70f4a6f4ba59ec4c6a630ed4c8a
Autor:
Simon Lindhoud, Willy A M van den Berg, Robert H H van den Heuvel, Albert J R Heck, Carlo P M van Mierlo, Willem J H van Berkel
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41363 (2012)
In organisms, various protective mechanisms against oxidative damaging of proteins exist. Here, we show that cofactor binding is among these mechanisms, because flavin mononucleotide (FMN) protects Azotobacter vinelandii flavodoxin against hydrogen p
Externí odkaz:
https://doaj.org/article/c0657a937ec941ee85eef1934c95b15a
Autor:
Vanessa M Y Ding, Paul J Boersema, Leong Yan Foong, Christian Preisinger, Geoffrey Koh, Subaashini Natarajan, Dong-Yup Lee, Jos Boekhorst, Berend Snel, Simone Lemeer, Albert J R Heck, Andre Choo
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17538 (2011)
The role of fibroblast growth factor-2 (FGF-2) in maintaining undifferentiated human embryonic stem cells (hESC) was investigated using a targeted phosphoproteomics approach to specifically profile tyrosine phosphorylation events following FGF-2 stim
Externí odkaz:
https://doaj.org/article/adbbe8a9de054032b918e4b6a0ff1945