Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Albert J, Sylvester"'
Autor:
Laurent Humeau, David Weiner, Robert H Vonderheide, Matthew P Morrow, Trevor McMullan, Anthony F Shields, Ashish V Chintakuntlawar, Kimberly A Kraynyak, Autumn J McRee, Jennifer M Johnson, Weijing Sun, Jan Pawlicki, Albert J Sylvester, Robert Samuels, Joseph J Kim, Jean D Boyer, Jeffrey M Skolnik
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background Human telomerase reverse transcriptase (hTERT) is frequently classified as a ‘universal’ tumor associated antigen due to its expression in a vast number of cancers. We evaluated plasmid DNA-encoded hTERT as an immunotherapy across nine
Externí odkaz:
https://doaj.org/article/a019d7273be04e4cbb43557f12c156de
Autor:
Jeffrey M, Jacobson, David, Zahrieh, Carrie A, Strand, Marcia, Cruz-Correa, Surakit, Pungpapong, Lewis R, Roberts, Sumithra J, Mandrekar, Luz María, Rodriguez, Jean, Boyer, Idania, Marrero, Kimberly A, Kraynyak, Matthew P, Morrow, Albert J, Sylvester, Jan M, Pawlicki, Elisabeth, Gillespie, Eduardo, Barranco, Ellen, Richmond, Asad, Umar, David B, Weiner, Paul J, Limburg
Publikováno v:
Cancer Prevention Research. 16:163-173
Chronic hepatitis C can lead to cirrhosis and hepatocellular carcinoma. We studied the safety and immunogenicity of a novel therapeutic hepatitis C virus (HCV) genotype 1a/1b consensus DNA vaccine, INO-8000, encoding HCV NS3, NS4A, NS4B, and NS5A pro
Autor:
Mark L. Bagarazzi, Cornelia L. Trimble, David B. Weiner, Stanley Plotkin, J. Joseph Kim, Niranjan Y. Sardesai, Laurent Humeau, Amir S. Khan, Russell Vang, Jian Yan, Jean D. Boyer, Dawson Knoblock, Michael Dallas, Albert J. Sylvester, Kimberly A. Kraynyak, Matthew P. Morrow
Supplemental Figure 1 - Rates of CIN2/3 regression (primary endpoint) or CIN2/3 regression concomitant with clearance of HPV16 and/or HPV18 infection (secondary endpoint) in the Per Protocol population of the Phase IIb study of VGX-3100 for the treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aba4a17eb58c63a1341c4b673bd3881
https://doi.org/10.1158/1078-0432.22467135.v1
https://doi.org/10.1158/1078-0432.22467135.v1
Autor:
Mark L. Bagarazzi, Cornelia L. Trimble, David B. Weiner, Stanley Plotkin, J. Joseph Kim, Niranjan Y. Sardesai, Laurent Humeau, Amir S. Khan, Russell Vang, Jian Yan, Jean D. Boyer, Dawson Knoblock, Michael Dallas, Albert J. Sylvester, Kimberly A. Kraynyak, Matthew P. Morrow
Purpose: As previously reported, treatment of high-grade cervical dysplasia with VGX-3100 resulted in complete histopathologic regression (CR) concomitant with elimination of HPV16/18 infection in 40.0% of VGX-3100–treated patients compared with on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b28af5e03ba2006f897889071c16ba8
https://doi.org/10.1158/1078-0432.c.6526548.v1
https://doi.org/10.1158/1078-0432.c.6526548.v1
Autor:
Mark L. Bagarazzi, Ildiko Csiki, David Weiner, Rakesh Kumar, Mark Esser, Susan Duff, Sandra Oyola, Michael Dallas, Russell Vang, Drishty Mangrolia, Kelsie Dickerson, Aubrey Anton, Sophie Tan, Lindsay Sakata, Jean Boyer, Alexander Lin, Gregory S. Weinstein, Joshua M. Bauml, Dawson M. Knoblock, Albert J. Sylvester, Kimberly A. Kraynyak, Matthew P. Morrow, Roger B. Cohen, Charu Aggarwal
Supplemental Table 2: Number of patients in each cohort with any seroreactivity against the candidate antigens (HPV 16,18 E6 and E7) at (A) any timepoint following vaccination and (B) three months following final vaccination Supplemental Table 3: Flo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00eabed1abfd4b80f484b655c53dec8d
https://doi.org/10.1158/1078-0432.22472916.v1
https://doi.org/10.1158/1078-0432.22472916.v1
Autor:
Mark L. Bagarazzi, Ildiko Csiki, David Weiner, Rakesh Kumar, Mark Esser, Susan Duff, Sandra Oyola, Michael Dallas, Russell Vang, Drishty Mangrolia, Kelsie Dickerson, Aubrey Anton, Sophie Tan, Lindsay Sakata, Jean Boyer, Alexander Lin, Gregory S. Weinstein, Joshua M. Bauml, Dawson M. Knoblock, Albert J. Sylvester, Kimberly A. Kraynyak, Matthew P. Morrow, Roger B. Cohen, Charu Aggarwal
Purpose:Clinical responses with programmed death (PD-1) receptor–directed antibodies occur in about 20% of patients with advanced head and neck squamous cell cancer (HNSCCa). Viral neoantigens, such as the E6/E7 proteins of HPV16/18, are attractive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6796bfeadb07acc04de8d95a04654454
https://doi.org/10.1158/1078-0432.c.6528372
https://doi.org/10.1158/1078-0432.c.6528372
Autor:
Mark L. Bagarazzi, Cornelia L. Trimble, David B. Weiner, Stanley Plotkin, J. Joseph Kim, Niranjan Y. Sardesai, Laurent Humeau, Amir S. Khan, Russell Vang, Jian Yan, Jean D. Boyer, Dawson Knoblock, Michael Dallas, Albert J. Sylvester, Kimberly A. Kraynyak, Matthew P. Morrow
Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::781222e7481bb332437ebd226d7503f2
https://doi.org/10.1158/1078-0432.22467138
https://doi.org/10.1158/1078-0432.22467138
Autor:
Mark L. Bagarazzi, Ildiko Csiki, David Weiner, Rakesh Kumar, Mark Esser, Susan Duff, Sandra Oyola, Michael Dallas, Russell Vang, Drishty Mangrolia, Kelsie Dickerson, Aubrey Anton, Sophie Tan, Lindsay Sakata, Jean Boyer, Alexander Lin, Gregory S. Weinstein, Joshua M. Bauml, Dawson M. Knoblock, Albert J. Sylvester, Kimberly A. Kraynyak, Matthew P. Morrow, Roger B. Cohen, Charu Aggarwal
Supplemental legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51803170b0d9f9397e5106bcc930d031
https://doi.org/10.1158/1078-0432.22472922.v1
https://doi.org/10.1158/1078-0432.22472922.v1
Autor:
Charu Aggarwal, Roger B. Cohen, Matthew P Morrow, Kimberly A Kraynyak, Albert J Sylvester, Jocelyn Cheung, Kelsie Dickerson, Veronique Schulten, Dawson Knoblock, Elisabeth Gillespie, Joshua M. Bauml, Jian Yan, Malissa Diehl, Jean Boyer, Michael Dallas, J. Joseph Kim, David B Weiner, Jeffrey M. Skolnik
Publikováno v:
Vaccines, Vol 8, Iss 1, p 56 (2020)
Background: Recurrent respiratory papillomatosis (RRP) is a rare disorder characterized by the generation of papillomas of the aerodigestive tract, usually associated with human papilloma virus (HPV) subtypes 6, 11. INO-3106 is a DNA plasmid-based im
Externí odkaz:
https://doaj.org/article/f4b8a7fdd42a4cab99ccb32b9c547661
Autor:
Matthew P Morrow, Kimberly A Kraynyak, Albert J Sylvester, Xuefei Shen, Dinah Amante, Lindsay Sakata, Lamar Parker, Jian Yan, Jean Boyer, Christian Roh, Laurent Humeau, Amir S Khan, Kate Broderick, Kathleen Marcozzi-Pierce, Mary Giffear, Jessica Lee, Cornelia L Trimble, J Joseph Kim, Niranjan Y Sardesai, David B Weiner, Mark L Bagarazzi
Publikováno v:
Molecular Therapy: Oncolytics, Vol 3, Iss C (2016)
We have previously demonstrated the immunogenicity of VGX-3100, a multicomponent DNA immunotherapy for the treatment of Human Papillomavirus (HPV)16/18-positive CIN2/3 in a phase 1 clinical trial. Here, we report on the ability to boost immune respon
Externí odkaz:
https://doaj.org/article/6cdec84404f44e6da5cce111757a5347