Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Albert I. Chen"'
Autor:
Jessica R. Gaunt, Norliyana Zainolabidin, Alaric K. K. Yip, Jia Min Tan, Aloysius Y. T. Low, Albert I. Chen, Toh Hean Ch’ng
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-27 (2023)
Abstract Alzheimer’s disease (AD) pathology and amyloid-beta (Aβ) plaque deposition progress slowly in the cerebellum compared to other brain regions, while the entorhinal cortex (EC) is one of the most vulnerable regions. Using a knock-in AD mous
Externí odkaz:
https://doaj.org/article/fc4eb1419a4f471fb294404841a20a6c
Autor:
Aloysius Y.T. Low, Ayesha R. Thanawalla, Alaric K.K. Yip, Jinsook Kim, Kelly L.L. Wong, Martesa Tantra, George J. Augustine, Albert I. Chen
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2322-2333 (2018)
Summary: The deep cerebellar nuclei (DCN) represent output channels of the cerebellum, and they transmit integrated sensorimotor signals to modulate limb movements. But the functional relevance of identifiable neuronal subpopulations within the DCN r
Externí odkaz:
https://doaj.org/article/7c9691c02c10440b8e69d126382b3d0e
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
GABAergic inhibitory neurons in the cerebellum are subdivided into Purkinje cells and distinct subtypes of interneurons from the same pool of progenitors, but the determinants of this diversification process are not well defined. To explore the trans
Externí odkaz:
https://doaj.org/article/c9697933b70442628b599b83f6a5e770
Autor:
Kuei-Pin Huang, Nitsan Goldstein, Mark A. Halko, Jessica Ruth Gaunt, Helen S. T. Ho, Nicholas Baltar, Laura E. Martin, October M. Sessions, Aloysius Y. T. Low, Roscoe O. Brady, Ju Y. Choi, Laura M. Holsen, Jamie R. E. Carty, Clara Lenherr, Norliyana Zainolabidin, Alekso M. Miller, J. Nicholas Betley, Eiman Azim, Amber L. Alhadeff, Albert I. Chen, Alaric K. K. Yip, Amanda S. Bruce, Toh Hean Ch'ng
Publikováno v:
Nature
The brain is the seat of body weight homeostasis. However, our inability to control the increasing prevalence of obesity highlights a need to look beyond canonical feeding pathways to broaden our understanding of body weight control1–3. Here we use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ec7311e188766259a5cbcf284d57a2
https://europepmc.org/articles/PMC8665128/
https://europepmc.org/articles/PMC8665128/
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(42)
The tight balance between synaptic excitation and inhibition (E/I) within neocortical circuits in the mammalian brain is important for complex behavior. Many loss-of-function studies have demonstrated that brain-derived neurotrophic factor (BDNF) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5b3a9ca0aebb33194af417502166473
https://pubmed.ncbi.nlm.nih.gov/30282736
https://pubmed.ncbi.nlm.nih.gov/30282736
Autor:
Alaric K. K. Yip, Jinsook Kim, Albert I. Chen, Kelly L. L. Wong, George J. Augustine, Martesa Tantra, Ayesha R. Thanawalla, Aloysius Y. T. Low
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2322-2333 (2018)
Summary: The deep cerebellar nuclei (DCN) represent output channels of the cerebellum, and they transmit integrated sensorimotor signals to modulate limb movements. But the functional relevance of identifiable neuronal subpopulations within the DCN r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55cdba754192d3e0c3aa98804d70353
http://hdl.handle.net/10220/44499
http://hdl.handle.net/10220/44499
Autor:
Sandhya Prakash Kamath, Albert I. Chen
Publikováno v:
Molecular Neurobiology
Mef2c haploinsufficiency is implicated in behavioral deficits related to autism, schizophrenia, and intellectual disability. Although perturbations in the cerebellum, notably Purkinje cells, have been linked to these neurological disorders, the under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9c10d1eb2d7ceb819b81e635453017
https://hdl.handle.net/10356/138987
https://hdl.handle.net/10356/138987
Conditional deletion of Cadherin 13 perturbs Golgi cells and disrupts social and cognitive behaviors
Autor:
Jinsook Kim, Albert I. Chen, M. Tantra, L. Guo, Volker Eulenburg, Norliyana Zainolabidin, George J. Augustine
Publikováno v:
Genes, Brain, and Behavior
Inhibitory interneurons mediate the gating of synaptic transmission and modulate the activities of neural circuits. Disruption of the function of inhibitory networks in the forebrain is linked to impairment of social and cognitive behaviors, but the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6aedfeb3846213c217737dc5349829
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/98786
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/98786
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Frontiers in Molecular Neuroscience, Vol 10 (2017)
GABAergic inhibitory neurons in the cerebellum are subdivided into Purkinje cells and distinct subtypes of interneurons from the same pool of progenitors, but the determinants of this diversification process are not well defined. To explore the trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eea3dbf8ae013c0e9327b91a50f2d3ed
https://pubmed.ncbi.nlm.nih.gov/28912684
https://pubmed.ncbi.nlm.nih.gov/28912684
Publikováno v:
Scientific reports, vol 6, iss 1
Scientific Reports
Chen, AI; Zang, K; Masliah, E; & Reichardt, LF. (2016). Glutamatergic axon-derived BDNF controls GABAergic synaptic differentiation in the cerebellum. SCIENTIFIC REPORTS, 6. doi: 10.1038/srep20201. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/9wz5164j
Scientific Reports
Chen, AI; Zang, K; Masliah, E; & Reichardt, LF. (2016). Glutamatergic axon-derived BDNF controls GABAergic synaptic differentiation in the cerebellum. SCIENTIFIC REPORTS, 6. doi: 10.1038/srep20201. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/9wz5164j
To study mechanisms that regulate the construction of inhibitory circuits, we examined the role of brain-derived neurotrophic factor (BDNF) in the assembly of GABAergic inhibitory synapses in the mouse cerebellar cortex. We show that within the cereb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f027a3a92dd1758404b0919cdb4306b