Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Albert Gründer"'
Autor:
Tanja Klein-Rodewald, Kateryna Micklich, Adrián Sanz-Moreno, Monica Tost, Julia Calzada-Wack, Thure Adler, Matthias Klaften, Sibylle Sabrautzki, Bernhard Aigner, Markus Kraiger, Valerie Gailus-Durner, Helmut Fuchs, German Mouse Clinic Consortium, Albert Gründer, Heike Pahl, Eckhard Wolf, Martin Hrabe de Angelis, Birgit Rathkolb
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Gastro-intestinal stromal tumors and acute myeloid leukemia induced by activating stem cell factor receptor tyrosine kinase (KIT) mutations are highly malignant. Less clear is the role of KIT mutations in the context of breast cancer. Treatm
Externí odkaz:
https://doaj.org/article/14dce610731c4ac3b187cabc3137d082
Publikováno v:
HemaSphere, Vol 5, Iss 5, p e565 (2021)
Even after development of the JAK1/JAK2 inhibitor ruxolitinib, myeloproliferative neoplasm (MPN) patients require novel therapeutic options. While ruxolitinib can considerably improve quality of life and prolong survival, it does not modify the natur
Externí odkaz:
https://doaj.org/article/f66e03f2b42847d99e9a14da8384fb4f
Autor:
Lukas Clemens Böckelmann, Titiksha Basu, Albert Gründer, Wei Wang, Jan Breucker, Sandra Kaiser, Andrea Pichler, Heike Luise Pahl
Publikováno v:
Haematologica, Vol 106, Iss 4 (2020)
Externí odkaz:
https://doaj.org/article/9cb5c5ce01d84a959d4140043ef76ff7
Autor:
Katharina Sies, Corinna Spohr, Albert Gründer, Rumyana Todorova, Franziska Maria Uhl, Julia Huber, Robert Zeiser, Heike Luise Pahl, Heiko Becker, Konrad Aumann, Tilman Brummer, Sebastian Halbach
Publikováno v:
HemaSphere, Vol 3, Iss 2 (2019)
Externí odkaz:
https://doaj.org/article/e8be1cd1ebd94896b7a4b6796222f10e
Autor:
Monika Gothwal, Julius Wehrle, Konrad Aumann, Vanessa Zimmermann, Albert Gründer, Heike L. Pahl
Publikováno v:
Haematologica, Vol 101, Iss 9 (2016)
We have recently demonstrated that the transcription factor nuclear factor-erythroid 2, which is critical for erythroid maturation and globin gene expression, plays an important role in the pathophysiology of myeloproliferative neoplasms. Myeloprolif
Externí odkaz:
https://doaj.org/article/145ed68bc4904fa882aec86cc1be5729
Autor:
Wei Wang, Jan Breucker, Heike L. Pahl, Lukas Clemens Böckelmann, Albert Gründer, Andrea Pichler, Titiksha Basu, Sandra Kaiser
Publikováno v:
Haematologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976ff3291a989914350f84050331f1b4
http://europepmc.org/articles/PMC8018143
http://europepmc.org/articles/PMC8018143
Autor:
Tanja, Klein-Rodewald, Kateryna, Micklich, Adrián, Sanz-Moreno, Monica, Tost, Julia, Calzada-Wack, Thure, Adler, Matthias, Klaften, Sibylle, Sabrautzki, Bernhard, Aigner, Markus, Kraiger, Valerie, Gailus-Durner, Helmut, Fuchs, Albert, Gründer, Heike, Pahl, Eckhard, Wolf, Martin, Hrabe de Angelis, Claudia, Stoeger
Publikováno v:
Scientific reports. 12(1)
Gastro-intestinal stromal tumors and acute myeloid leukemia induced by activating stem cell factor receptor tyrosine kinase (KIT) mutations are highly malignant. Less clear is the role of KIT mutations in the context of breast cancer. Treatment succe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd7fd897d2c41720b31576b110b56fd4
https://pubmed.ncbi.nlm.nih.gov/36396684
https://pubmed.ncbi.nlm.nih.gov/36396684
Autor:
Christoph Koellerer, Albert Gründer, Mathijs A. Sanders, Manuela Simoni, Laura Riccetti, Heike L. Pahl, Jerzy-Roch Nofer, Peter J. M. Valk, Jonas S. Jutzi, Carsten Müller-Tidow, Fengbiao Zhou, Samuel Vorbach, Francesco Potì
Publikováno v:
Leukemia, 34(3), 721-734. Nature Publishing Group
Acute myeloid leukemia (AML) carries a 10–100 fold lower mutational burden than other neoplastic entities. Mechanistic explanations for why a low number of mutations suffice to induce leukemogenesis are therefore required. Here we demonstrate that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb707d0458f143e2e572ab3d682e6567
https://doi.org/10.1038/s41375-019-0577-7
https://doi.org/10.1038/s41375-019-0577-7
Autor:
Laura C. Siegwart, Thalia S. Seeger, Julius Wehrle, Sven Schwemmers, Albert Gründer, Heike L. Pahl, Christoph Koellerer
Publikováno v:
Experimental hematology. 87
Activity of the transcription factor NFE2 is elevated in the majority of patients with myeloproliferative neoplasms (MPNs), either by overexpression of the wild-type alleles or by the presence of an activating mutation. In murine models, enhanced NFE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32ad62fa0af82b35f4f2b7e884ce9204
https://pubmed.ncbi.nlm.nih.gov/32593672
https://pubmed.ncbi.nlm.nih.gov/32593672
Autor:
Heiko Becker, Tilman Brummer, Albert Gründer, Sebastian Halbach, Heike L. Pahl, Franziska M. Uhl, Julia Huber, Rumyana Todorova, Robert Zeiser, Corinna Spohr, Konrad Aumann, Katharina Sies
Publikováno v:
HemaSphere
HemaSphere, Vol 3, Iss 2 (2019)
HemaSphere, Vol 3, Iss 2 (2019)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584a479da9e95b77344c6850ed371f1d
http://europepmc.org/articles/PMC6746037
http://europepmc.org/articles/PMC6746037