Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Albert Galera‐Prat"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract ADP-ribosyltransferases PARP1 and PARP2 play a major role in DNA repair mechanism by detecting the DNA damage and inducing poly-ADP-ribosylation dependent chromatin relaxation and recruitment of repair proteins. Catalytic PARP inhibitors are
Externí odkaz:
https://doaj.org/article/727b9cd0eeaf41c0ba3dc9660a674d86
Autor:
Dr. Patricia Korn, Arno Classen, Dr. Sudarshan Murthy, Dr. Riccardo Guareschi, Mirko M. Maksimainen, Barbara E. Lippok, Albert Galera‐Prat, Sven T. Sowa, Catharina Voigt, Prof. Dr. Giulia Rossetti, Prof. Dr. Lari Lehtiö, Prof. Dr. Carsten Bolm, Prof. Dr. Bernhard Lüscher
Publikováno v:
ChemistryOpen, Vol 10, Iss 10, Pp 939-948 (2021)
Abstract Intracellular ADP‐ribosyltransferases catalyze mono‐ and poly‐ADP‐ribosylation and affect a broad range of biological processes. The mono‐ADP‐ribosyltransferase PARP10 is involved in signaling and DNA repair. Previous studies ide
Externí odkaz:
https://doaj.org/article/0e125f0171b24e93b9aec1f09fcdc7ff
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Poly(ADP-ribose) polymerase 2 (PARP2) is activated by 5′-phosphorylated DNA breaks but the molecular mechanism is not fully understood. Here, the authors report a crystal structure of PARP2 bound to an activating DNA fragment, providing insights in
Externí odkaz:
https://doaj.org/article/3e12a12ec89744fea3a04b2b30548e8f
Autor:
Rubén Hervás, María del Carmen Fernández-Ramírez, Albert Galera-Prat, Mari Suzuki, Yoshitaka Nagai, Marta Bruix, Margarita Menéndez, Douglas V. Laurents, Mariano Carrión-Vázquez
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-14 (2021)
Abstract Background Amyloids are ordered, insoluble protein aggregates, characterized by a cross-β sheet quaternary structure in which molecules in a β-strand conformation are stacked along the filament axis via intermolecular interactions. While a
Externí odkaz:
https://doaj.org/article/424f921c44eb4d14bf0ae0e29dc08050
Autor:
Sven T. Sowa, Albert Galera-Prat, Sarah Wazir, Heli I. Alanen, Mirko M. Maksimainen, Lari Lehtiö
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101147- (2022)
Summary: Here, we describe a protocol to set up a screening assay for ADP-ribosyl binding proteins including proteins that possess O-glycosidase or N-glycosidase activities. The FRET-based assay measures the interaction of any ADP-ribosyl binding pro
Externí odkaz:
https://doaj.org/article/5757d53f46f04a1595194b95e88c4132
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1688 (2022)
Tankyrases are poly-ADP-ribosyltransferases that regulate many crucial and diverse cellular processes in humans such as Wnt signaling, telomere homeostasis, mitotic spindle formation and glucose metabolism. While tankyrases are present in most animal
Externí odkaz:
https://doaj.org/article/c88ed3dc5bc543089e8f5ee72fa3dd34
Autor:
Rubén Hervás, Liying Li, Amitabha Majumdar, María Del Carmen Fernández-Ramírez, Jay R Unruh, Brian D Slaughter, Albert Galera-Prat, Elena Santana, Mari Suzuki, Yoshitaka Nagai, Marta Bruix, Sergio Casas-Tintó, Margarita Menéndez, Douglas V Laurents, Kausik Si, Mariano Carrión-Vázquez
Publikováno v:
PLoS Biology, Vol 14, Iss 1, p e1002361 (2016)
Amyloids are ordered protein aggregates that are typically associated with neurodegenerative diseases and cognitive impairment. By contrast, the amyloid-like state of the neuronal RNA binding protein Orb2 in Drosophila was recently implicated in memo
Externí odkaz:
https://doaj.org/article/77f95cb5f9284cf6befdeef4b438bc58
Autor:
Héctor R Méndez-Gómez, Albert Galera-Prat, Craig Meyers, Weijun Chen, Jasbir Singh, Mariano Carrión-Vázquez, Nicholas Muzyczka
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)
Crossing the bloodâbrain and the bloodâcerebrospinal fluid barriers (BCSFB) is one of the fundamental challenges in the development of new therapeutic molecules for brain disorders because these barriers prevent entry of most drugs from the blood i
Externí odkaz:
https://doaj.org/article/5fe3c387774a410da3338d5073bfeaf4
Autor:
Rubén Hervás, Javier Oroz, Albert Galera-Prat, Oscar Goñi, Alejandro Valbuena, Andrés M Vera, Angel Gómez-Sicilia, Fernando Losada-Urzáiz, Vladimir N Uversky, Margarita Menéndez, Douglas V Laurents, Marta Bruix, Mariano Carrión-Vázquez
Publikováno v:
PLoS Biology, Vol 10, Iss 5, p e1001335 (2012)
Amyloidogenic neurodegenerative diseases are incurable conditions with high social impact that are typically caused by specific, largely disordered proteins. However, the underlying molecular mechanism remains elusive to established techniques. A fav
Externí odkaz:
https://doaj.org/article/ace39d0bb3a74abdb135fcb523029e9a
Autor:
Jo Waaler, Stefan Krauss, Anita Wegert, Ruben G.G. Leenders, Ilonka A.T.M. Meerts, Lari Lehtiö, Albert Galera-Prat, Sven T. Sowa, Gunnveig Grødeland, Hanne Scholz, Merete Høyem, Lone Holmen, Petter A. Olsen, Aleksandra Aizenshtadt, Clara Hammarström, Sandra Espada, Enya Amundsen-Isaksen, Shoshy A. Brinch
Supplementary Figure S1. Chemical structures of selected tankyrase inhibitors. Supplementary Figure S2. OM-153 specifically inhibits TNKS1/2 and WNT/β-catenin signaling. Supplementary Figure S3. OM-153 specifically inhibits cell growth of an APC-mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae321b85444944ba3b4b1f59b1193c2
https://doi.org/10.1158/2767-9764.22544588.v1
https://doi.org/10.1158/2767-9764.22544588.v1