Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Albert G. Zimmermann"'
Mutations that impair the proliferation of enteric neural crest-derived cells (ENCDC) cause Hirschsprung disease, a potentially lethal birth defect where the enteric nervous system (ENS) is absent from distal bowel. Inosine 5' monophosphate dehydroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba05a9e9ac9725f24cca2637bcaac184
Autor:
Irving C. Allen, Denis Gris, Beckley K. Davis, Yu Lei, John B. Bowzard, Jenny P.-Y. Ting, Raymond J. Pickles, Priya Ranjan, Kathryn M. Monroe, Suryaprakash Sambhara, Monika Schneider, Albert G. Zimmermann, Kelly E. Roney, Chris B. Moore, Margaret A. Scull
Publikováno v:
Immunity. 34(6):854-865
Summary The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) proteins regulate innate immunity. Although the positive regulatory impact of NLRs is clear, their inhibitory roles are not well defined. We showed that Nlrx1 −/− mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b614281f4959833f71d6c2216c1e53c4
Autor:
Eda K. Holl, T. Matt Holl, Albert G. Zimmermann, Brian P. O'Connor, Kelly E. Roney, Garnett Kelsoe, Sushmita Jha, Jenny P.-Y. Ting
Publikováno v:
The Journal of Immunology. 186:5603-5611
Long-lived humoral immune responses depend upon the generation of memory B cells and long-lived plasma cells during the germinal center (GC) reaction. These memory compartments, characterized by class-switched IgG and high-affinity Abs, are the basis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfb7ff95d6a14e410501e2545512c9b
https://doi.org/10.4049/jimmunol.1003464
https://doi.org/10.4049/jimmunol.1003464
Publikováno v:
Journal of Biological Chemistry. 274:22705-22712
We have isolated the 5' region of the ecto-5'-nucleotidase (low K(m) 5'-NT) gene and established that a 969-base pair (bp) fragment confers cell-specific expression of a CAT reporter gene that correlates with the expression of endogenous ecto-5'-NT m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c001292193d84b1872cbdca6839d293
https://doi.org/10.1074/jbc.274.32.22705
https://doi.org/10.1074/jbc.274.32.22705
Publikováno v:
Journal of Biological Chemistry. 272:22913-22923
Expression of the gene encoding human inosine- 5'-monophosphate dehydrogenase (IMPDH) type II, an enzyme catalyzing the rate-limiting step in the generation of guanine nucleotides, is increased more than 10-fold in activated peripheral blood T lympho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f87a1fd7a5a4d6b24ac07b423d653366
https://doi.org/10.1074/jbc.272.36.22913
https://doi.org/10.1074/jbc.272.36.22913
Autor:
Albert G, Zimmermann, Yue, Sun
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1031
Murine gene knockout models engineered over the last two decades have continued to demonstrate their potential as invaluable tools in understanding the role of gene function in the context of normal human development and disease. The more recent eluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8b12fbaece16a64c8d2d67134fd6b12
https://pubmed.ncbi.nlm.nih.gov/23824881
https://pubmed.ncbi.nlm.nih.gov/23824881
Autor:
Albert G. Zimmermann, Yue Sun
Publikováno v:
Mouse Models of Innate Immunity ISBN: 9781627034807
Murine gene knockout models engineered over the last two decades have continued to demonstrate their potential as invaluable tools in understanding the role of gene function in the context of normal human development and disease. The more recent eluc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2214a80493853fb8907f5a9e09a2b14e
https://doi.org/10.1007/978-1-62703-481-4_1
https://doi.org/10.1007/978-1-62703-481-4_1
Publikováno v:
Advances in Enzyme Regulation. 36:75-84
Inosine 5′-monophosphate dehydrogenase (IMPDH) is an essential ratelimiting enzyme in the de novo guanine nucleotide synthetic pathway that catalyzes the conversion of IMP to XMP. Enzyme activity is accounted for by the expression of two distinct b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ba4a3f7e06542fe10fed9dc48e227c
https://doi.org/10.1016/0065-2571(95)00012-7
https://doi.org/10.1016/0065-2571(95)00012-7
Autor:
Zhengmao Ye, Beverly H. Koller, Brian J. Conti, Irving C. Allen, Haitao Wen, Monika Schneider, Albert G. Zimmermann, Timothy K. Eitas, Karen V. Swanson, Reid A. Roberts, Beckley K. Davis, Jenny P.-Y. Ting, Adeeb H. Rahman, Eda K. Holl, Lu Zhang
Publikováno v:
Nature immunology. 13(9)
Several members of the NLR family of sensors activate innate immunity. In contrast, we found here that NLRC3 inhibited Toll-like receptor (TLR)-dependent activation of the transcription factor NF-κB by interacting with the TLR signaling adaptor TRAF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f283721e53f933ea188a53d541158a2
https://pubmed.ncbi.nlm.nih.gov/22863753
https://pubmed.ncbi.nlm.nih.gov/22863753
Autor:
Joseph A. Duncan, Albert G. Zimmermann, Daniel T. Bergstralh, Zhengmao Ye, Stephen B. Willingham, Jenny P.-Y. Ting, Yanhong Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 104(19)
The CATERPILLER (CLR/NLR) gene family encodes a family of putative nucleotide-binding proteins important for host defense. Although nucleotide binding is thought to be central to this family, this aspect is largely unstudied. The CATERPILLER protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74e7cdfabdc747104605c8814bc7a45
https://pubmed.ncbi.nlm.nih.gov/17483456
https://pubmed.ncbi.nlm.nih.gov/17483456