Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Albert Felten"'
Autor:
Joseph A. Reddy, Melissa Nelson, Christina Dircksen, Marilynn Vetzel, Theresa Johnson, Vicky Cross, Elaine Westrick, LongWu Qi, Spencer Hahn, Hari Krishna Santhapuram, Garth Parham, Kevin Wang, Jeremy F. Vaughn, Albert Felten, Michael Pugh, June Lu, Patrick Klein, Iontcho R. Vlahov, Christopher P. Leamon
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Abstract Folate receptor (FR)-targeted small molecule drug conjugates (SMDCs) have shown promising results in early stage clinical trials with microtubule destabilizing agents, such as vintafolide and EC1456. In our effort to develop FR-targeted SMDC
Externí odkaz:
https://doaj.org/article/62cffd133d60412fb62fcc23f334889b
Autor:
Iontcho Radoslavov Vlahov, Garth L. Parham, Patrick J. Klein, Elaine Westrick, June Lu, Christopher P. Leamon, Christina Dircksen, Marilynn Vetzel, Jeremy F. Vaughn, Albert Felten, Melissa Nelson, Vicky A. Cross, Longwu Qi, Kevin Wang, Hari Krishna Santhapuram, Joseph A. Reddy, Theresa Johnson, Spencer Hahn, Michael Pugh
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Folate receptor (FR)-targeted small molecule drug conjugates (SMDCs) have shown promising results in early stage clinical trials with microtubule destabilizing agents, such as vintafolide and EC1456. In our effort to develop FR-targeted SMDCs with va
Autor:
Jeff Nicoson, Kevin Wang, Fei You, Hanna F. Klein, Longwu Qi, Jeremy F. Vaughn, Iontcho Radoslavov Vlahov, Hari Krishna Santhapuram, Joe Reddy, Dan Reno, Garth L. Parham, Paul J. Kleindl, Spencer Hahn, Ning Zou, Christopher P. Leamon, Albert Felten
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(7)
Pyrrolobenzodiazepines (PBDs) and their dimers (bis-PBDs) have emerged as some of the most potent chemotherapeutic compounds and are currently under development as novel payloads in antibody-drug conjugates (ADCs). However, when used as stand-alone t
Autor:
Jeremy F. Vaughn, Joseph A. Reddy, Hari Krishna Santhapuram, Fei You, Hanna F. Klein, Melissa Nelson, Albert Felten, Longwu Qi, Paul J. Kleindl, Christopher P. Leamon, Iontcho Radoslavov Vlahov, Jeff Nicoson, Spencer Hahn, Marilynn Vetzel, Kevin Wang, Garth L. Parham
Publikováno v:
Bioconjugate Chemistry. 28:2921-2931
Pyrrolobenzodiazepines (PBDs) and their dimers (bis-PBDs) have emerged as some of the most potent chemotherapeutic compounds, and are currently under development as novel payloads in antibody-drug conjugates (ADCs). However, when used as stand-alone
Publikováno v:
Cytotoxic Payloads for Antibody – Drug Conjugates ISBN: 9781788010771
Pyrrolobenzodiazepines (PBDs) and their dimers have emerged as some of the most potent chemotherapeutic compounds, and are currently under development as novel payloads in antibody–drug conjugates (ADCs). However, when used as stand-alone therapeut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b4d57e5829c79e89be44c1b65e10fbf
https://doi.org/10.1039/9781788012898-00279
https://doi.org/10.1039/9781788012898-00279
Autor:
Albert Felten, Hari Krishna Santhapuram, Spencer Hahn, Ning Zou, Christopher P. Leamon, Kevin K.W. Wang, Jeremy F. Vaughn, Paul J. Kleindl, Iontcho Radoslavov Vlahov
Publikováno v:
Cancer Research. 78:757-757
Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antibiotics are a class of natural products produced by various actinomycetes bacteria. PBD-dimers function as sequence-selective DNA-crosslinking, alkylating compounds which are considerably more potent than s
Autor:
Elaine Westrick, Leroy W. Wheeler, Hari Krishna Santhapuram, Joseph A. Reddy, Iontcho Radoslavov Vlahov, Albert Felten, Christopher P. Leamon, Melissa Nelson, Le-Cun Xu, Marilynn Vetzel
Publikováno v:
Cancer Research. 78:852-852
Prostate-specific membrane antigen (PSMA) is a biomarker that is overexpressed on prostate cancer as well as on the neovasculature of many non-prostate solid tumors. Lately, several small molecular PSMA binding ligands chelated to various radionuclid
Autor:
Christopher P. Leamon, Paul J. Kleindl, Jeremy F. Vaughn, Albert Felten, Spencer Hahn, Iontcho Radoslavov Vlahov, Longwu Qi, Hari Krishna Santhapuram, Kevin K.W. Wang
Publikováno v:
Cancer Research. 77:5147-5147
Pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antibiotics, are a class of natural products produced by various actinomycetes bacteria. PBDs are sequence selective DNA-crosslinking alkylating compounds and are considerably more potent than systemic chemothe
Autor:
Nikki Parker, Haiyan Chu, Jonathan M. Shillingford, Yingjuan Lu, Jeremy F. Vaughn, Joseph A. Reddy, Melissa Nelson, Iontcho Radoslavov Vlahov, Christopher P. Leamon, Albert Felten
Publikováno v:
Cancer Research. 77:4017-4017
With the development of molecularly-targeted therapeutics, it is critical to have a reliable method for predicting response to therapy of patients with target-expressing diseases. Folate receptor (FR) is overexpressed in a number of disease states wh