Nanopillar Templating Augments the Stiffness and Strength in Biopolymer Films

Autor: Sara Heedy, Juviarelli J. Pineda, Vijaykumar S. Meli, Szu-Wen Wang, Albert F. Yee

Publikováno v: ACS Nano. 16:3311-3322

Natural load-bearing mammalian tissues, such as cartilage and ligaments, contain ∼70% water yet can be mechanically stiff and strong due to the highly templated structures within. Here, we present a bioinspired approach to significantly stiffen and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50ec68ff5c62c50a2cfc3de7d479075
https://doi.org/10.1021/acsnano.1c11378

Importance of Sub-Nanosecond Fluctuations on the Toughness of Polycarbonate Glasses

Autor: Madhusudan Tyagi, Christopher L. Soles, Adam B. Burns, Edwin P. Chan, Albert F. Yee, Kanae Ito, Jianwei Liu

Publikováno v: Macromolecules. 53:6672-6681

This article explores the relationship between the nano- to picosecond dynamics, as quantified by elastic incoherent neutron scattering, in polycarbonate (PC) glasses with their mechanical toughnes...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7223f4ba23c44adc007c693ad1a17b8f
https://doi.org/10.1021/acs.macromol.0c00857

Synergistic Antimicrobial Activity of a Nanopillar Surface on a Chitosan Hydrogel

Autor: Juviarelli J. Pineda, Eric Pearlman, Michaela E. Marshall, Sara Heedy, Albert F. Yee

Publikováno v: ACS applied bio materials. 3(11)

Despite ongoing efforts and technology development, the contamination of medical device surfaces by disease-causing microbes remains problematic. Two approaches to producing antimicrobial surfaces are using antimicrobial materials and applying physic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7ad9fe29d117da7354da72de24d3fa
https://pubmed.ncbi.nlm.nih.gov/35019543

Correlation of focal adhesion assembly and disassembly with cell migration on nanotopography

Autor: Michelle A. Digman, Albert F. Yee, Elena I. Liang, Emma J. Mah

Publikováno v: Liang, Elena I; Mah, Emma J; Yee, Albert F; & Digman, Michelle A. (2017). Correlation of focal adhesion assembly and disassembly with cell migration on nanotopography.. Integrative biology : quantitative biosciences from nano to macro, 9(2), 145-155. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/77w3t1p6

Selective cell adhesion is desirable to control cell growth and migration on biomedical implants. Mesenchymal cell migration is regulated through focal adhesions (FAs) and can be modulated by their microenvironment, including changes in surface topog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc99727d8fc0a56dab7f2edb3567c22b
https://doi.org/10.1039/c6ib00193a

Collagen density modulates triple-negative breast cancer cell metabolism through adhesion-mediated contractility

Autor: Austin E. Y. T. Lefebvre, Michelle A. Digman, Emma J. Mah, Gabrielle E. McGahey, Albert F. Yee

Publikováno v: Mah, Emma J; Lefebvre, Austin EYT; McGahey, Gabrielle E; Yee, Albert F; & Digman, Michelle A. (2018). Collagen density modulates triple-negative breast cancer cell metabolism through adhesion-mediated contractility.. Scientific reports, 8(1), 17094. doi: 10.1038/s41598-018-35381-9. UC Office of the President: Research Grants Program Office (RGPO). Retrieved from: http://www.escholarship.org/uc/item/9sb7g6bf
Scientific Reports
Scientific reports, vol 8, iss 1
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)

Extracellular matrix (ECM) mechanical properties upregulate cancer invasion, cell contractility, and focal adhesion formation. Alteration in energy metabolism is a known characteristic of cancer cells (i.e., Warburg effect) and modulates cell invasio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49ec8fe0ab824f706cdaf46536a1d9bc
http://www.escholarship.org/uc/item/9sb7g6bf