Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Albert Escobedo"'
Autor:
Albert Escobedo, Jonathan Piccirillo, Juan Aranda, Tammo Diercks, Borja Mateos, Carla Garcia-Cabau, Macarena Sánchez-Navarro, Busra Topal, Mateusz Biesaga, Lasse Staby, Birthe B. Kragelund, Jesús García, Oscar Millet, Modesto Orozco, Murray Coles, Ramon Crehuet, Xavier Salvatella
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Targeting biomedically relevant protein-protein interactions is a long-lasting challenge in medicinal chemistry. Here, the authors develop a single α-helical peptide scaffold that can be tailored to target globular proteins of biomedical interest.
Externí odkaz:
https://doaj.org/article/0ea4c921c75c4f04849c5efbc9071b23
Autor:
Albert Escobedo, Busra Topal, Micha B. A. Kunze, Juan Aranda, Giulio Chiesa, Daniele Mungianu, Ganeko Bernardo-Seisdedos, Bahareh Eftekharzadeh, Margarida Gairí, Roberta Pierattelli, Isabella C. Felli, Tammo Diercks, Oscar Millet, Jesús García, Modesto Orozco, Ramon Crehuet, Kresten Lindorff-Larsen, Xavier Salvatella
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Polyglutamine (polyQ) tracts are low-complexity regions and their expansion is linked to certain neurodegenerative diseases. Here the authors combine experimental and computational approaches to find that the length of the androgen receptor polyQ tra
Externí odkaz:
https://doaj.org/article/1f190bc76aba4d9fb248940a644fa9a9
Autor:
Shaon Basu, Paula Martínez-Cristóbal, Mireia Pesarrodona, Marta Frigolé-Vivas, Michael Lewis, Elzbieta Szulc, C. Adriana Bañuelos, Carolina Sánchez-Zarzalejo, Stasė Bielskutė, Jiaqi Zhu, Karina Pombo-García, Carla Garcia-Cabau, Cristina Batlle, Borja Mateos, Mateusz Biesaga, Albert Escobedo, Lídia Bardia, Xavier Verdaguer, Alessandro Ruffoni, Nasrin R. Mawji, Jun Wang, Teresa Tam, Isabelle Brun-Heath, Salvador Ventura, David Meierhofer, Jesús García, Paul Robustelli, Travis H. Stracker, Marianne D. Sadar, Antoni Riera, Denes Hnisz, Xavier Salvatella
SummaryTranscription factors are among the most attractive therapeutic targets but are considered largely undruggable due to the intrinsically disordered nature of their activation domains. Here we show that the aromatic character of the activation d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::647a49166ea017e1660f5ae923fe0668
https://doi.org/10.1101/2022.08.18.504385
https://doi.org/10.1101/2022.08.18.504385
Publikováno v:
Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname
Bioconjugate Chemistry
instname
Bioconjugate Chemistry
The two-dimensional (2D) homogeneous assembly of nanoparticle monolayer arrays onto a broad range of substrates constitutes an important challenge for chemistry, nanotechnology, and material science. α-Synuclein (αS) is an intrinsically disordered
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2141
High solvent exposure of certain sequences located in intrinsically disordered regions (IDRs) may eventually lead to aggregation, as is the case for some low-complexity regions (LCRs) and short linear motifs (SLiMs). In particular, polyglutamine (pol
Publikováno v:
Methods in Molecular Biology ISBN: 9781071605233
High solvent exposure of certain sequences located in intrinsically disordered regions (IDRs) may eventually lead to aggregation, as is the case for some low-complexity regions (LCRs) and short linear motifs (SLiMs). In particular, polyglutamine (pol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76b09f6b6c3fd4b3222922ddf971880f
https://doi.org/10.1007/978-1-0716-0524-0_10
https://doi.org/10.1007/978-1-0716-0524-0_10
Autor:
Tammo Diercks, Micha B. A. Kunze, Oscar Millet, Jesús García, Busra Topal, Albert Escobedo, Giulio Chiesa, Xavier Salvatella, Isabella C. Felli, Modesto Orozco, Kresten Lindorff-Larsen, Juan Aranda, Roberta Pierattelli, Ramon Crehuet, Bahareh Eftekharzadeh
Publikováno v:
Biophysical Journal. 118:369a-370a
Autor:
Kresten Lindorff-Larsen, Juan Aranda, Jesús T. García, Ganeko Bernardo-Seisdedos, Giulio Chiesa, Ramon Crehuet, Oscar Millet, Margarida Gairí, Micha B. A. Kunze, Busra Topal, Xavier Salvatella, Daniele Mungianu, Albert Escobedo, Bahareh Eftekharzadeh, Roberta Pierattelli, Isabella C. Felli, Tammo Diercks, Modesto Orozco
Publikováno v:
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Escobedo, A, Topal, B, Kunze, M B A, Aranda, J, Chiesa, G, Mungianu, D, Bernardo-Seisdedos, G, Eftekharzadeh, B, Gairí, M, Pierattelli, R, Felli, I C, Diercks, T, Millet, O, García, J, Orozco, M, Crehuet, R, Lindorff-Larsen, K & Salvatella, X 2019, ' Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor ', Nature Communications, vol. 10, 2034 . https://doi.org/10.1038/s41467-019-09923-2
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Escobedo, A, Topal, B, Kunze, M B A, Aranda, J, Chiesa, G, Mungianu, D, Bernardo-Seisdedos, G, Eftekharzadeh, B, Gairí, M, Pierattelli, R, Felli, I C, Diercks, T, Millet, O, García, J, Orozco, M, Crehuet, R, Lindorff-Larsen, K & Salvatella, X 2019, ' Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor ', Nature Communications, vol. 10, 2034 . https://doi.org/10.1038/s41467-019-09923-2
Polyglutamine (polyQ) tracts are regions of low sequence complexity frequently found in transcription factors. Tract length often correlates with transcriptional activity and expansion beyond specific thresholds in certain human proteins is the cause
Autor:
Oscar Millet, Giulio Chiesa, Busra Topal, Jesús García, Roberta Pierattelli, Tammo Diercks, Micha B. A. Kunze, Isabella C. Felli, Juan Aranda, Xavier Salvatella, Daniele Mungianu, Modesto Orozco, Bahareh Eftekharzadeh, Margarida Gairí, Ramon Crehuet, Kresten Lindorff-Larsen, Ganeko Bernardo-Seisdedos, Albert Escobedo
Polyglutamine (polyQ) tracts are regions of low sequence complexity of variable length found in more than one hundred human proteins. These tracts are frequent in activation domains of transcription factors and their length often correlates with tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0cd28275f996d7110ef2696a9179794
https://doi.org/10.1101/447896
https://doi.org/10.1101/447896
Autor:
Pau Martin-Malpartida, Albert Escobedo, Maria J. Macias, Lidia Ruiz, Eric Aragón, Tiago Gomes
Publikováno v:
Structure. 22(10):1446-1457
Summary We investigated the mechanisms of activation and degradation of the E3 ubiquitin ligase Nedd4L combining the available biochemical information with complementary biophysical techniques. Using nuclear magnetic resonance spectroscopy, we identi