Zobrazeno 1 - 10
of 454
pro vyhledávání: '"Albert D. Windhorst"'
Autor:
Federica Bonanno, Ran Sing Saw, Daniel Bleher, Ioannis Papadopoulos, Gregory D. Bowden, Kaare Bjerregaard-Andersen, Albert D. Windhorst, Bernd J. Pichler, Kristina Herfert, Andreas Maurer
Publikováno v:
ACS Omega, Vol 9, Iss 23, Pp 24774-24788 (2024)
Externí odkaz:
https://doaj.org/article/bded1bd3bd34484c848df899721fc131
Autor:
Ruixue Xia, Shuang Shi, Zhenmei Xu, Henry F. Vischer, Albert D. Windhorst, Yu Qian, Yaning Duan, Jiale Liang, Kai Chen, Anqi Zhang, Changyou Guo, Rob Leurs, Yuanzheng He
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The histamine H4 receptor (H4R) plays key role in immune cell function and is a highly valued target for treating allergic and inflammatory diseases. However, structural information of H4R remains elusive. Here, we report four cryo-EM struct
Externí odkaz:
https://doaj.org/article/bb329f6ecb7241a28d3a490e5bc87b0e
Autor:
Xavier Palard-Novello, Denise Visser, Nelleke Tolboom, Charlotte L. C. Smith, Gerben Zwezerijnen, Elsmarieke van de Giessen, Marijke E. den Hollander, Frederik Barkhof, Albert D. Windhorst, Bart NM van Berckel, Ronald Boellaard, Maqsood Yaqub
Publikováno v:
EJNMMI Physics, Vol 11, Iss 1, Pp 1-13 (2024)
Abstract Background Accurate image-derived input function (IDIF) from highly sensitive large axial field of view (LAFOV) PET/CT scanners could avoid the need of invasive blood sampling for kinetic modelling. The aim is to validate the use of IDIF for
Externí odkaz:
https://doaj.org/article/14582a280aeb4cb5b8e15da9c4eba088
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
Immunotherapy targeted to immune checkpoint inhibitors, such as the program cell death receptor (PD-1) and its ligand (PD-L1), has revolutionized cancer treatment. However, it is now well-known that PD-1/PD-L1 immunotherapy response is inconsistent a
Externí odkaz:
https://doaj.org/article/0a96982e3b674bd28cdbd407459036bb
Autor:
Antonia A. Högnäsbacka, Alex J. Poot, Christophe Plisson, Jonas Bergare, David R. Bonsall, Stuart P. McCluskey, Lisa A. Wells, Esther Kooijman, Robert C. Schuit, Mariska Verlaan, Wissam Beaino, Guus A. M. S. van Dongen, Danielle J. Vugts, Charles S. Elmore, Jan Passchier, Albert D. Windhorst
Publikováno v:
EJNMMI Research, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Background Mutations in the epidermal growth factor receptor (EGFR) kinase domain are common in non-small cell lung cancer. Conventional tyrosine kinase inhibitors target the mutation site in the ATP binding pocket, thereby inhibiting the re
Externí odkaz:
https://doaj.org/article/625cc69bf6ed4690bf32bf9fa866699c
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-31 (2023)
Abstract Background Positron emission tomography (PET) is a powerful, non-invasive preclinical and clinical nuclear imaging technique used in disease diagnosis and therapy assessment. Fluorine-18 is the predominant radionuclide used for PET tracer sy
Externí odkaz:
https://doaj.org/article/c441d1b7df3c4c29ab3acf5ac9bf233c
Autor:
Juliana M. Nieuwland, Erik Nutma, Ingrid H. C. H. M. Philippens, Kinga P. Böszörményi, Edmond J. Remarque, Jaco Bakker, Lisette Meijer, Noor Woerdman, Zahra C. Fagrouch, Babs E. Verstrepen, Jan A. M. Langermans, Ernst J. Verschoor, Albert D. Windhorst, Ronald E. Bontrop, Helga E. de Vries, Marieke A. Stammes, Jinte Middeldorp
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Background Coronavirus disease 2019 (COVID-19) patients initially develop respiratory symptoms, but they may also suffer from neurological symptoms. People with long-lasting effects after acute infections with severe respiratory syndrome cor
Externí odkaz:
https://doaj.org/article/7deba191465348f99f359569106a989d
Autor:
Lonneke Rotteveel, Alex J. Poot, Esther J. M. Kooijman, Robert C. Schuit, Ingrid Schalij, Xiaoqing Sun, Kondababu Kurakula, Chris Happé, Wissam Beaino, Peter ten Dijke, Adriaan A. Lammertsma, Harm Jan Bogaard, Albert D. Windhorst
Publikováno v:
EJNMMI Research, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Transforming growth factor β (TGFβ) activity is perturbed in remodelled pulmonary vasculature of patients with pulmonary arterial hypertension (PAH), cancer, vascular diseases and developmental disorders. Inhibition of TGFβ, which signals
Externí odkaz:
https://doaj.org/article/d4e5834623554ec79cfeb8672ef8eb29
Autor:
Jarith L. Ebenau, Denise Visser, Lior A. Kroeze, Mardou S. S. A. van Leeuwenstijn, Argonde C. van Harten, Albert D. Windhorst, Sandeep V. S. Golla, Ronald Boellaard, Philip Scheltens, Frederik Barkhof, Bart N. M. van Berckel, Wiesje M. van der Flier
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-12 (2022)
Abstract Background Biomarkers for amyloid, tau, and neurodegeneration (ATN) have predictive value for clinical progression, but it is not clear how individuals move through these stages. We examined changes in ATN profiles over time, and investigate
Externí odkaz:
https://doaj.org/article/2a10f0eecc1f491fb787668eb12f36a8
Autor:
Hayel Tuncel, Ronald Boellaard, Emma M. Coomans, Marijke den Hollander-Meeuwsen, Erik F. J. de Vries, Andor W. J. M. Glaudemans, Paula Kopschina Feltes, David Vállez García, Sander C. J. Verfaillie, Emma E. Wolters, Steven P. Sweeney, J. Michael Ryan, Magnus Ivarsson, Berkley A. Lynch, Patrick Schober, Philip Scheltens, Robert C. Schuit, Albert D. Windhorst, Peter P. De Deyn, Bart N. M. van Berckel, Sandeep S. V. Golla
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract [11C]UCB-J is a PET radioligand that binds to the presynaptic vesicle glycoprotein 2A. Therefore, [11C]UCB-J PET may serve as an in vivo marker of synaptic integrity. The main objective of this study was to evaluate the quantitative accuracy
Externí odkaz:
https://doaj.org/article/1d98093e987342dd9416579091feee0d