Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Albert Cheong"'
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
PDF file - 2.9MB, In-vitro kinase assay, Histology, Cell proliferation, MANOVA analysis for genomic correlates of drug sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ecb3048e6ff5affcb194a51978b5d1
https://doi.org/10.1158/1535-7163.22497421
https://doi.org/10.1158/1535-7163.22497421
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
Dysregulation of the PI3K/mTOR pathway, either through amplifications, deletions, or as a direct result of mutations, has been closely linked to the development and progression of a wide range of cancers. Moreover, this pathway activation is a poor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::389efae3908c20bd53e37aa050195e71
https://doi.org/10.1158/1535-7163.c.6535609
https://doi.org/10.1158/1535-7163.c.6535609
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
PDF file - 663K, Ambit kinome tree, Cell proliferation data, Pharmacokinetics, Body weight changes in PC3 efficacy study, Active vessel stain in COLO-205 efficacy study, MV4-11 efficacy model, Drug sensitivity profiling and correlation to mutation st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407e7e397fec9712aed4f01696117bc4
https://doi.org/10.1158/1535-7163.22497424
https://doi.org/10.1158/1535-7163.22497424
Autor:
Jeanette M. Wood, Brian Dymock, Mathew Garnett, Ultan McDermott, Cyril Benes, Boon Cher Goh, Nurulhuda Mustafa, Wee Joo Chng, Kantharaj Ethirajulu, Khalid M. Pasha, Ramesh Jayaraman, Harish Nagaraj, Babita Madan, Chithra Amalini, Bee Kheng Ng, Albert Cheong, Lai Chun Ong, Yong Cheng Tan, Meredith Williams, Kee Chuan Goh, Veronica Novotny-Diermayr, Stefan Hart
XLS file - 167K, Table 1: Cell line drug sensitivity data for SB2343 and mutations in cancer genes. Table 2: Results from MANOVA analysis of cancer genes as modifiers of drug sensitivity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794bb76ff68be2e6a52cec2e5c03efb5
https://doi.org/10.1158/1535-7163.22497418
https://doi.org/10.1158/1535-7163.22497418
Conservation defines functional motifs in the squint/nodal-related 1 RNA dorsal localization element
Publikováno v:
Nucleic Acids Research
RNA localization is emerging as a general principle of sub-cellular protein localization and cellular organization. However, the sequence and structural requirements in many RNA localization elements remain poorly understood. Whereas transcription fa
Publikováno v:
Gene. 304:107-115
Myotonic dystrophy kinase-related Cdc42-binding kinase alpha (MRCKalpha) is a Cdc42/Rac interactive binding-containing serine/threonine kinase with multiple functional domains. Its roles in the regulation of peripheral actin reorganization in HeLa ce
Publikováno v:
Nature. 450:E2-E4
Replying to: J. T. Bennett et al. , doi:10.1038/nature06314 (2007) We presented several lines of evidence indicating that dorso–ventral asymmetry is apparent in zebrafish embryos by cleavage stages1, one of which showed that injection of three diff
Autor:
Jeanette Marjorie Wood, Ramesh Jayaraman, Yong Cheng Tan, Stefan Hart, Khalis M Pasha, Veronica Novotny-Diermayr, Albert Cheong, Kantharaj Ethirajulu, Nurulhuda Mustafa, B. K. Ng, Lai Chun Ong, Boon Cher Goh, Chithra Amalini, Wee Joo Chng, Babita Madan, Ultan McDermott, Meredith Williams, Harish Kumar Mysore Nagaraj, Kee Chuan Goh, Brian W. Dymock, Cyril H. Benes, Mathew J. Garnett
Dysregulation of the PI3K/mTOR pathway, either through amplifications, deletions, or as a direct result of mutations, has been closely linked to the development and progression of a wide range of cancers. Moreover, this pathway activation is a poor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5563f504dd744af76e5286ea49281647
https://europepmc.org/articles/PMC3588144/
https://europepmc.org/articles/PMC3588144/
Autor:
Grant Buchanan, Wayne D. Tilley, Villis R. Marshall, Charles J. Ryan, Albert Cheong, Howard I. Scher, Amelia A. Peters, Nicole L. Moore, Eleanor F. Need, Gary A. Wittert
The androgen receptor (AR) is an important signaling molecule in multiple tissues, yet its mode of action and cell-specific activities remain enigmatic. AR function has been best studied in the prostate, in which it is essential for growth and homeos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2cadc859d7fa0a4ef658ef6b09d2e36
https://europepmc.org/articles/PMC2689802/
https://europepmc.org/articles/PMC2689802/
Autor:
Albert Cheong, Karuna Sampath, Eric S. Weinberg, Patrick C. Gilligan, Aniket V. Gore, Shingo Maegawa
Publikováno v:
Nature. 438(7070)
A central question in the development of multicellular organisms pertains to the timing and mechanisms of specification of the embryonic axes. In many organisms, specification of the dorsoventral axis requires signalling by proteins of the Transformi