Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Albert Braunwalder"'
Autor:
Albert Braunwalder, Michael Williams
Publikováno v:
Journal of Neurochemistry. 47:88-97
Adenine nucleotides displace the binding of the selective adenosine A-1 receptor ligand [3H]cyclopentyladenosine (CPA) to rat brain membranes in a concentration-dependent manner, with the rank order of activity being ATP greater than ADP greater than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969247c918d3d61800f71710afe3ddef
https://doi.org/10.1111/j.1471-4159.1986.tb02835.x
https://doi.org/10.1111/j.1471-4159.1986.tb02835.x
Autor:
W. D. Cash, Albert Braunwalder, P.S. Bernard, G. C. Mazzenga, R. A. Lovell, B. S. Barbaz, Francis John E, J. L. Hyun, Debra A. Bennett, R. C. Friedmann, P. S. Loo
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5e7514324fefecbf5dee278114703a6
https://doi.org/10.1002/chin.199123167
https://doi.org/10.1002/chin.199123167
Publikováno v:
Analytical biochemistry. 238(2)
A nonradioactive, sensitive assay method to evaluate the activity of protein tyrosine kinases is described. This method utilizes europium chelate-labeled anti-phosphotyrosine antibodies to detect phosphate transfer to a polymeric substrate coated ont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5c0d9410f63a3c65ea79e5802d1908
https://pubmed.ncbi.nlm.nih.gov/8660605
https://pubmed.ncbi.nlm.nih.gov/8660605
Autor:
James Wasvary, Isidoros Vlattas, James L. Stanton, Albert Braunwalder, Bruce Seligmann, Matthew A. Sills, James Dellureficio, Galakatos Nicholas G, Richard Kramer, Iou Iou Sytwu
Publikováno v:
Journal of medicinal chemistry. 37(17)
In order to identify regions of C5a that contribute to receptor binding and functional activity of the anaphylatoxin, a series of peptides was synthesized in which core segments have been attached to C-terminal segments via native peptidic or disulfi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf174e45d8bc5402c1b7b002aa085f
https://pubmed.ncbi.nlm.nih.gov/8064805
https://pubmed.ncbi.nlm.nih.gov/8064805
Autor:
Galakatos Nicholas G, Matthew J. Toth, William O. Haston, Matthew A. Sills, Donna R. Yarwood, Bruce Seligmann, Albert Braunwalder, William C. Boyar, Leslie Huwyler, Joseph T. Hadala
We have determined which amino acids contribute to the pharmacophore of human C5a, a potent inflammatory mediator. A systematic mutational analysis of this 74-amino acid protein was performed and the effects on the potency of receptor binding and of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77975a36b4e3a2a39e16669dc49efbe
https://europepmc.org/articles/PMC2142918/
https://europepmc.org/articles/PMC2142918/
Autor:
Shou-Ih Hu, Lynnette Conder, Sid Vlattas, Albert Braunwalder, Catherine L. Cioffi, Lawrence P. Wennogle, Richard Kramer, Cindy Winter
Publikováno v:
Journal of cellular biochemistry. 55(3)
Binding of biotin-C5a to the C5a receptor in membrane fragments followed by detergent solubilization and purification with streptavidin-agarose affinity chromatography resulted in the isolation of a receptor complex with associated G-proteins. In con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caaa09c706424900ba093fd290916392
https://pubmed.ncbi.nlm.nih.gov/7962171
https://pubmed.ncbi.nlm.nih.gov/7962171
Autor:
R. A. Lovell, J. L. Hyun, R. C. Friedmann, Francis John E, P. S. Loo, P.S. Bernard, G. C. Mazzenga, B. S. Barbaz, W. D. Cash, Albert Braunwalder
Publikováno v:
Journal of medicinal chemistry. 34(1)
Investigation of tricyclic heterocycles related to the 2-arylpyrazolo[4,3-c]quinolin-3(5H)-ones, structures with high affinity for the benzodiazepine (BZ) receptor, led to the synthesis of 2-phenyl-[1,2,4]triazolo[1,5-c]quinazolin-5(6H)-one, a compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff1e62a2a144f9438eeefcaa2e2a533
https://pubmed.ncbi.nlm.nih.gov/1846920
https://pubmed.ncbi.nlm.nih.gov/1846920
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 332:179-183
The binding of [3H]-Cyclopentyladenosine (CPA), an N6-substituted analog of adenosine, was examined in vitro. CPA bound with high affinity (Kd = 0.48 nmol/l) to rat brain membranes. Specific binding, which represented 90-97% of the total counts bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a889f10303166386a68fe7c5d78fc2a
https://doi.org/10.1007/bf00511410
https://doi.org/10.1007/bf00511410
Autor:
P.S. Bernard, Susan Gerhardt, Patricia Loo, Jeffrey M. Liebman, Naokata Yokoyama, Caryl L. Amrick, Carl A. Boast, Markus Schmutz, Albert Braunwalder, D. Wilson, Debra A. Bennett, Klaus Klebs
Publikováno v:
Drug Development Research. 11:219-233
CGS 17867A (2-(4-chlorophenyl)-2,5,6,7,8,9,-hexahydor-3H-pyrazolo [4,3,-c]quinoline-3-one-hydrochloride salt) is a tetrahydorpyrazoloquinoline related to the benzodiazepine (BZ) receptor agonist, CGS 9896. The compound is an effective inhibitor of [3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::874a82b64a60bd99e213ae3c96b65f04
https://doi.org/10.1002/ddr.430110309
https://doi.org/10.1002/ddr.430110309
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 8:785-788
The efficacy of coupling between the benzodiazepine receptor and chloride channel as well as the coupling to the GABA receptor is differentially affected by different benzodiazepine ligands. In general, the order of efficacy with regard to allosteric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37d12de0180feee715fb5146857394b
https://doi.org/10.1016/0278-5846(84)90059-9
https://doi.org/10.1016/0278-5846(84)90059-9