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Autor:
Peter W. Seale, Peter John Murray, Andrew B. Holmes, Mark Ladlow, Frédéric Berst, Simon L. Croft, Richard J. Upton, Paul Stead, Albert Andrzej Glaxo Wellcome plc Jaxa-Chamiec, William Clegg, Michael Kranz, Kenneth Keavey, Stephen Taylor, Mark R. J. Elsegood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:773-776
A novel synthetic strategy is described which may be used to prepare analogues of the antimalarial, fungal metabolite apicidin. Compared to the natural product, one analogue shows potent and selective activity in vitro against the parasite Trypanosom