Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Albert Agustinus"'
Autor:
Mathieu F. Bakhoum, Jasmine H. Francis, Albert Agustinus, Ethan M. Earlie, Melody Di Bona, David H. Abramson, Mercedes Duran, Ignas Masilionis, Elsa Molina, Alexander N. Shoushtari, Michael H. Goldbaum, Paul S. Mischel, Samuel F. Bakhoum, Ashley M. Laughney
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The molecular underpinnings driving uveal melanoma (UM) progression are unknown. Here the authors show that loss of Polycomb Repressive Complex 1 triggers chromosomal instability, which promotes inflammatory signaling and migration in UM.
Externí odkaz:
https://doaj.org/article/3bfb2543650b4dffa2fb1404ab14b57d
Autor:
Efrat Finkin-Groner, Amni Al-Kachak, Albert Agustinus, Ryan Bastle, Ashley Lepack, Yang Lyu, Ian Maze, Yael David
Publikováno v:
bioRxiv
Recent advances in protein engineering have provided a wealth of methods that allow for the site-specific manipulation of proteinsin vitroand in cells. However, the efforts to expand these toolkits for use in live animals has been limited. Here, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfaef821adf5c5e749c4fa9eafd4ef97
https://europepmc.org/articles/PMC10055299/
https://europepmc.org/articles/PMC10055299/
Autor:
Yang Bai, Albert Agustinus, Cem Meydan, Dylan R. McNally, Shira Yomtoubian, Liron Yoffe, Ari M. Melnick, Samuel Bakhoum, Vivek Mittal
Publikováno v:
Cancer Research. 83:5811-5811
Metastasis is the leading cause of cancer-related death among women with breast cancer. Chromosomal instability (CIN) has emerged as a hallmark of triple-negative breast cancer (TNBC) as it has recently been shown to promote metastasis. However, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d1eeab5e3da147ef457a9932230a578
https://doi.org/10.1158/1538-7445.am2023-5811
https://doi.org/10.1158/1538-7445.am2023-5811
Autor:
Merav Antman-Passig, Eitan Wong, Georgia R. Frost, Christian Cupo, Janki Shah, Albert Agustinus, Ziyu Chen, Chiara Mancinelli, Maikel Kamel, Thomas Li, Lauren A. Jonas, Yue-Ming Li, Daniel A. Heller
Publikováno v:
ACS Nano
Amyloid-beta (Aβ) deposition occurs in the early stages of Alzheimer’s disease (AD), but the early detection of Aβ is a persistent challenge. Herein, we engineered a near-infrared optical nanosensor capable of detecting Aβ intracellularly in liv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23057c3c9c35a6898c952c17e0f7ba74
https://pubmed.ncbi.nlm.nih.gov/35420796
https://pubmed.ncbi.nlm.nih.gov/35420796
Autor:
Albert Agustinus, Ramya Raviram, Bhargavi Dameracharla, Jens Luebeck, Stephanie Stransky, Lorenzo Scipioni, Robert M. Myers, Melody Di Bona, Mercedes Duran, Britta Weigelt, Shira Yomtoubian, Eléonore Toufektchan, Paul S. Mischel, Vivek Mittal, Sohrab Shah, John Maciejowski, Enrico Gratton, Peter Ly, Mathieu F. Bakhoum, Dan Landau, Vineet Bafna, Simone Sidoli, Yael David, Samuel F. Bakhoum
Chromosomal instability (CIN) and epigenetic alterations are characteristics of advanced and metastatic cancers [1-4], yet whether they are mechanistically linked is unknown. Here we show that missegregation of mitotic chromosomes, their sequestratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bca96ab2ad7e1411c903ace33782445f
https://doi.org/10.1101/2022.01.12.475944
https://doi.org/10.1101/2022.01.12.475944
Autor:
Albert Agustinus, Mercedes Duran, Michael H. Goldbaum, David H. Abramson, Paul S. Mischel, Ashley M. Laughney, Jasmine H. Francis, Alexander N. Shoushtari, Mathieu F. Bakhoum, Melody Di Bona, Ethan M. Earlie, Samuel F. Bakhoum, Elsa Molina, Ignas Masilionis
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Chromosomal instability (CIN) and epigenetic alterations have been implicated in tumor progression and metastasis; yet how these two hallmarks of cancer are related remains poorly understood. By integrating genetic, epigenetic, and functional analyse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c02d8097512dfd8970de2673fbbcc19
https://escholarship.org/uc/item/20b57582
https://escholarship.org/uc/item/20b57582
Autor:
Jana Biermann, Johannes C. Melms, Amit Dipak Amin, Yiping Wang, Lindsay A. Caprio, Alcida Karz, Somnath Tagore, Irving Barrera, Miguel A. Ibarra-Arellano, Massimo Andreatta, Benjamin T. Fullerton, Kristjan H. Gretarsson, Varun Sahu, Vaibhav S. Mangipudy, Trang T.T. Nguyen, Ajay Nair, Meri Rogava, Patricia Ho, Peter D. Koch, Matei Banu, Nelson Humala, Aayushi Mahajan, Zachary H. Walsh, Shivem B. Shah, Daniel H. Vaccaro, Blake Caldwell, Michael Mu, Florian Wünnemann, Margot Chazotte, Simon Berhe, Adrienne M. Luoma, Joseph Driver, Matthew Ingham, Shaheer A. Khan, Suthee Rapisuwon, Craig L. Slingluff, Thomas Eigentler, Martin Röcken, Richard Carvajal, Michael B. Atkins, Michael A. Davies, Albert Agustinus, Samuel F. Bakhoum, Elham Azizi, Markus Siegelin, Chao Lu, Santiago J. Carmona, Hanina Hibshoosh, Antoni Ribas, Peter Canoll, Jeffrey N. Bruce, Wenya Linda Bi, Praveen Agrawal, Denis Schapiro, Eva Hernando, Evan Z. Macosko, Fei Chen, Gary K. Schwartz, Benjamin Izar
Publikováno v:
Cell
Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma, yet our understanding of the underlying salient biology is rudimentary. Here, we performed single-cell/nucleus RNA-seq in 22 treatment-naïve MBM and 10 extracrania
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffeb8cdc8ddd73723b19f34d8d372008
https://doi.org/10.1016/j.cell.2022.06.007
https://doi.org/10.1016/j.cell.2022.06.007
Autor:
Melody Di Bona, Albert Agustinus, Yanyang Chen, Lorenzo Scipioni, Daniel Bronder, Samuel F. Bakhoum
Publikováno v:
Cancer Research. 82:1589-1589
Chromosomal instability is a hallmark of aggressive human cancers and it is often associated with metastasis, immune evasion, and therapeutic resistance. Chromosomally unstable tumors often contain rupture-prone micronuclei, which harbor mis-segregat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8da534f15ab838259b94b3d45685b518
https://doi.org/10.1158/1538-7445.am2022-1589
https://doi.org/10.1158/1538-7445.am2022-1589
Autor:
Wan Fang Wong, Daniel A. Heller, Merav Antman-Passig, Georgia Frost, Chiara Mancinelli, Ziyu Chen, Maikel Kamel, Albert Agustinus
Publikováno v:
ECS Meeting Abstracts. :3410-3410
Alzheimer’s disease (AD) and other dementias are the 5th leading cause of death globally and pose an increasing global health challenge as the proportions of elderly population increase demographically. Although research aimed at providing treatmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a739a5260418bf11aeebd68e9166f80
https://doi.org/10.1149/ma2020-02673410mtgabs
https://doi.org/10.1149/ma2020-02673410mtgabs