Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Albert A. Manian"'
Autor:
Albert A. Manian, Joyce J. Kaufman
Publikováno v:
International Journal of Quantum Chemistry. 6:375-381
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14bb47050d88eab576ee5014e04329fe
https://doi.org/10.1002/qua.560060639
https://doi.org/10.1002/qua.560060639
Publikováno v:
Journal of Medicinal Chemistry. 22:196-199
The electrochemical oxidations of several hydroxylated derivatives of promazine, chlorpromazine, imipramine, and 3-chloroimipramine are examined and compared. Oxidation of the monohydroxyphenothiazine derivatives leads to both dihydroxy species and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0ff4d7cbfe464fa93f79cf7c2ce7e97
https://doi.org/10.1021/jm00188a014
https://doi.org/10.1021/jm00188a014
Publikováno v:
Life Sciences. 18:685-691
The relative muscarinic anticholinergic actions of phenothiazines and related drugs are thought to regulate the propensity of these agents to elicit extrapyramidal side effects, especially those resembling the symptoms of Parkinson's disease. Pimozid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931adad3c46f8d0357213368f39f5732
https://doi.org/10.1016/0024-3205(76)90179-x
https://doi.org/10.1016/0024-3205(76)90179-x
Publikováno v:
Journal of Heterocyclic Chemistry. 14:107-112
The synthesis of 7-hydroxy, 8-hydroxy and 7,8-dihydroxy prochlorperazines (3a) and per-phenazines (3b) is reported. The parent ehlorophenothiazines were prepared analogously to previously reported chlorpromazine (3e) metabolite syntheses. The prochlo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45537aca0fcdbdef011bd630e299663e
https://doi.org/10.1002/jhet.5570140121
https://doi.org/10.1002/jhet.5570140121
Publikováno v:
Brain Research. 104:401-406
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49961e3d7c7f65f6800f7d282d74a1b6
https://doi.org/10.1016/0006-8993(76)90640-5
https://doi.org/10.1016/0006-8993(76)90640-5
Publikováno v:
European Journal of Pharmacology. 38:205-209
Cyclic guanosine 3' ,5'-monophosphate(cyclic GMP) levels were increased in incubated tissue slices from rat cerebral cortex in response to added cholinomimetic agents (carbachol and choline chloride) and neuroleptic compounds (chlorpromazine, 8-hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9f5b5d00374fdd19fc657acec10b955
https://doi.org/10.1016/0014-2999(76)90220-x
https://doi.org/10.1016/0014-2999(76)90220-x
Publikováno v:
Journal of Heterocyclic Chemistry. 13:1067-1072
The syntheses of di- and trihydroxychlorpromazines, I, II, III, and V, and of dioxo derivatives, IV and VI, are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ac9317eba10a74d94ded5774cecc611
https://doi.org/10.1002/jhet.5570130526
https://doi.org/10.1002/jhet.5570130526
Publikováno v:
Journal of Heterocyclic Chemistry. 16:1227-1232
The syntheses of dioxogenated chlorpromazines 1, 2, and 3 via the reductive ring closure of substituted nitrodiphenyl sulfides are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9d63f7e8c58ffeaf9ed5153d9195223
https://doi.org/10.1002/jhet.5570160627
https://doi.org/10.1002/jhet.5570160627
Publikováno v:
European Journal of Pharmacology. 47:291-296
A series of chlorpromazine metabolites and derivatives have been assayed for their ability to compete with 3H-haloperidol binding to dopamine receptors in membranes of rat corpus striatum. 3-Hydroxylation of chlorpromazine doubles affinity for recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba5773fb5ef4295b7d170e71b8998c2
https://doi.org/10.1016/0014-2999(78)90236-4
https://doi.org/10.1016/0014-2999(78)90236-4
Publikováno v:
Biochemical Pharmacology. 24:363-369
7,8-Dihydroxychlorpromazine, 7,8-dihydroxyprochlorperazine and 7,8-dihydroxyperphenazine all reacted with O 2 to make hydrogen peroxide (H 2 O 2 ). The rate of reaction between the ortho -dihydroxyphenothiazines and O 2 was increased by superoxide di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4906e60bb62c29bb19354e9f470fb32c
https://doi.org/10.1016/0006-2952(75)90219-1
https://doi.org/10.1016/0006-2952(75)90219-1