Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Albert, Gerding"'
Autor:
Ligia Akemi Kiyuna, Kishore Alagere Krishnamurthy, Esther B. Homan, Miriam Langelaar-Makkinje, Albert Gerding, Trijnie Bos, Dorenda Oosterhuis, Ruben J. Overduin, Andrea B. Schreuder, Vincent E. de Meijer, Peter Olinga, Terry G. J. Derks, Karen van Eunen, Barbara M. Bakker, Maaike H. Oosterveer
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Fasting hypoglycemia is a severe and incompletely understood symptom of various inborn errors of metabolism (IEM). Precision-cut liver slices (PCLS) represent a promising model for studying glucose production ex vivo. This study quantified t
Externí odkaz:
https://doaj.org/article/80c7e8fec88b4b8f9ec36708526d3646
Autor:
Kirsten T. Nijholt, Pablo I. Sánchez-Aguilera, Belend Mahmoud, Albert Gerding, Justina C. Wolters, Anouk H. G. Wolters, Ben N. G. Giepmans, Herman H. W. Silljé, Rudolf A. de Boer, Barbara M. Bakker, B. Daan Westenbrink
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract A Kinase Interacting Protein 1 (AKIP1) is a signalling adaptor that promotes mitochondrial respiration and attenuates mitochondrial oxidative stress in cultured cardiomyocytes. We sought to determine whether AKIP1 influences mitochondrial fu
Externí odkaz:
https://doaj.org/article/0f6febf0dad84f44a4fe25e6b176abbe
Autor:
Christoff Odendaal, Emmalie A. Jager, Anne-Claire M. F. Martines, Marcel A. Vieira-Lara, Nicolette C. A. Huijkman, Ligia A. Kiyuna, Albert Gerding, Justina C. Wolters, Rebecca Heiner-Fokkema, Karen van Eunen, Terry G. J. Derks, Barbara M. Bakker
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background Monogenetic inborn errors of metabolism cause a wide phenotypic heterogeneity that may even differ between family members carrying the same genetic variant. Computational modelling of metabolic networks may identify putative sourc
Externí odkaz:
https://doaj.org/article/c317aa533e824a27ae9be54b9fd0b3e9
Autor:
Mara P.H. van Trijp, Melany Rios-Morales, Ben Witteman, Fentaw Abegaz, Albert Gerding, Ran An, Martijn Koehorst, Bernard Evers, Katja C.V. van Dongen, Erwin G. Zoetendal, Henk Schols, Lydia A. Afman, Dirk-Jan Reijngoud, Barbara M. Bakker, Guido J. Hooiveld
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109208- (2024)
Summary: Consumption of fructo- (FOS) and galacto-oligosaccharides (GOS) has health benefits which have been linked in part to short-chain fatty acids (SCFA) production by the gut microbiota. However, detailed knowledge of this process in the human i
Externí odkaz:
https://doaj.org/article/cd41ade7fb8e4d98876000536f453c8e
Autor:
Catriona Ling, Christian J. Versloot, Matilda E. Arvidsson Kvissberg, Guanlan Hu, Nathan Swain, José M. Horcas-Nieto, Emily Miraglia, Mehakpreet K. Thind, Amber Farooqui, Albert Gerding, Karen van Eunen, Mirjam H. Koster, Niels J. Kloosterhuis, Lijun Chi, YueYing ChenMi, Miriam Langelaar-Makkinje, Celine Bourdon, Jonathan Swann, Marieke Smit, Alain de Bruin, Sameh A. Youssef, Marjon Feenstra, Theo H. van Dijk, Kathrin Thedieck, Johan W. Jonker, Peter K. Kim, Barbara M. Bakker, Robert H.J. Bandsma
Publikováno v:
EBioMedicine, Vol 96, Iss , Pp 104809- (2023)
Summary: Background: The intestine of children with severe malnutrition (SM) shows structural and functional changes that are linked to increased infection and mortality. SM dysregulates the tryptophan-kynurenine pathway, which may impact processes s
Externí odkaz:
https://doaj.org/article/030dcd61c99342418554af2a1f59e28d
Autor:
Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins, Marjan Geugien, Alan Cunningham, Maurien G. Pruis, Isabel Weinhäuser, Albert Gerding, Barbara M. Bakker, Albertus T. J. Wierenga, Eduardo M. Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Inhibition of specific metabolic pathways often drives metabolic adaptation. Here, the authors show that FLT3-ITD + acute myeloid leukemia cells are OXPHOS-driven, and inhibition of complex II activity results in increased lactate influx to drive res
Externí odkaz:
https://doaj.org/article/c6190c32ad6545bcbde3640dce0f4ff7
Autor:
Marcel A. Vieira-Lara, Marleen B. Dommerholt, Wenxuan Zhang, Maaike Blankestijn, Justina C. Wolters, Fentaw Abegaz, Albert Gerding, Ydwine T. van der Veen, Rachel Thomas, Ronald P. van Os, Dirk-Jan Reijngoud, Johan W. Jonker, Janine K. Kruit, Barbara M. Bakker
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-18 (2021)
Abstract Background The skeletal muscle plays a central role in glucose homeostasis through the uptake of glucose from the extracellular medium in response to insulin. A number of factors are known to disrupt the normal response to insulin leading to
Externí odkaz:
https://doaj.org/article/a9716da0b74d420cb0e3c1ac024d69e9
Autor:
Melany Rios-Morales, Mara P. H. van Trijp, Christiane Rösch, Ran An, Theo Boer, Albert Gerding, Naomi de Ruiter, Martijn Koehorst, M. Rebecca Heiner-Fokkema, Henk A. Schols, Dirk-Jan Reijngoud, Guido J. E. J. Hooiveld, Barbara M. Bakker
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Detailed knowledge on the fate of dietary components inside the human intestinal tract is lacking. Access to this inner world of digestion is now possible through novel human gastrointestinal sampling capsules. Due to the novelty of such dev
Externí odkaz:
https://doaj.org/article/06a21ae74d734b99a00a021edd180d58
Autor:
Andries Heida, Nanda Gruben, Leen Catrysse, Martijn Koehorst, Mirjam Koster, Niels J. Kloosterhuis, Albert Gerding, Rick Havinga, Vincent W. Bloks, Laura Bongiovanni, Justina C. Wolters, Theo van Dijk, Geert van Loo, Alain de Bruin, Folkert Kuipers, Debby P.Y. Koonen, Bart van de Sluis
Publikováno v:
Molecular Metabolism, Vol 54, Iss , Pp 101349- (2021)
Objective: Obesity-related chronic inflammation plays an important role in the development of Metabolic Associated Fatty Liver Disease (MAFLD). Although the contribution of the pro-inflammatory NF-κB signaling pathway to the progression from simple
Externí odkaz:
https://doaj.org/article/54c1ebb08d38492b9a76c2c3c92de6e6
Autor:
Koen D. W. Hendriks, Isabel M. A. Brüggenwirth, Hanno Maassen, Albert Gerding, Barbara Bakker, Robert J. Porte, Robert H. Henning, Henri G. D. Leuvenink
Publikováno v:
Journal of Translational Medicine, Vol 17, Iss 1, Pp 1-10 (2019)
Abstract Background Hypothermia, leading to mitochondrial inhibition, is widely used to reduce ischemic injury during kidney preservation. However, the exact effect of hypothermic kidney preservation on mitochondrial function remains unclear. Methods
Externí odkaz:
https://doaj.org/article/e772a71da13c40ab8cae6bfb04fae314