Targeting interleukin-6 as a treatment approach for peritoneal carcinomatosis

Autor: Neda Dadgar, Christopher Sherry, Jenna Zimmerman, Hyun Park, Catherine Lewis, Albert Donnenberg, Ali H. Zaidi, Yong Fan, Kunhong Xiao, David Bartlett, Vera Donnenberg, Patrick L. Wagner

Publikováno v: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-18 (2024)

Abstract Peritoneal carcinomatosis (PC) is a complex manifestation of abdominal cancers, with a poor prognosis and limited treatment options. Recent work identifying high concentrations of the cytokine interleukin-6 (IL-6) and its soluble receptor (s

Externí odkaz: https://doaj.org/article/a71ee4cc59e64df78edf01e2021607ca

INTRAPLEURAL THERAPY TO DISRUPT IL-6/IL-8 JUXTACTINE SIGNALLING TO BLOCK TUMOR EMT AND TO DRIVE SYSTEMIC ANTI-TUMOR IMMUNITY

Autor: Vera Donnenberg, Albert Donnenberg, Ibrahim Sultan, Shannon Puhalla, James Luketich, Christie Hilton, David Bartlett

Publikováno v: Hematology, Transfusion and Cell Therapy, Vol 44, Iss , Pp S24-S25 (2022)

Objective: The goal of this study was to determine whether antiIL-6Rα block (tocilizumab) will alter the pleural secretome and will diminish tumor-specific immune responses. Methodology: Pleural T cells were isolated from freshly drained pleural eff

Externí odkaz: https://doaj.org/article/b99e8ddc87e14aa9b2b216ec16e5fca4

1435 Comparison of the cytokine and chemokine secretome of benign and malignant peritoneal fluid identifies FGF and IL 1R alpha as potential drivers of tumor growth

Autor: Patrick Wagner, Vera Donnenberg, Christian Cruz Pico, Albert Donnenberg, David Bartlett

Publikováno v: Regular and Young Investigator Award Abstracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4537ab395250407f3bfe5fecf18d2cde
https://doi.org/10.1136/jitc-2022-sitc2022.1435

Contributors

Autor: Graça Almeida-Porada, Greg Asatrian, Anthony Atala, Stephen F. Badylak, Pedro M. Baptista, Cameron Best, Khalil N. Bitar, Christopher K. Breuer, Bryan N. Brown, Raphaël F. Canadas, Arnold I. Caplan, Irene Cervelló, William C.W. Chen, Dong F. Chen, Martin K. Childers, Kin-Sang Cho, Claudio J. Conti, A. Crespo-Barreda, Marcela Del Río, Giacomo Della Verde, Abritee Dhal, Albert Donnenberg, M.M. Encabo-Berzosa, Ignacio Giménez, Melissa A. Goddard, R. González-Pastor, Riccardo Gottardi, Xuan Guan, Sara Guerrero-Aspizua, Chenying Guo, Winters Hardy, Ira M. Herman, Catalina K. Hwang, M. Iglesias, Glicerio Ignacio, Aaron W. James, Thi H. Khanh Vu, Nobuaki Kikyo, Joanne Kurtzberg, Gabriela M. Kuster, Angel Lanas, Mark T. Langhans, Fernando Larcher, Avione Y. Lee, Yong-Ung Lee, Ronglih Liao, Jr-Jiun Liou, David L. Mack, Nathan Mahler, Alexandra P. Marques, Kacey G. Marra, P. Martin-Duque, Patricia Meade, Jose Vicente Medrano, Emma Moran, Joaquim M. Oliveira, P. Ortíz-Teba, Bruno Péault, Otmar Pfister, Sandra Pina, Christopher D. Porada, Rui L. Reis, J. Peter Rubin, Keith Sabin, Natalia Sánchez-Romero, Alvaro Santamaria, J.L. Serrano, Anthony R. Sheets, Carlos Simón, Shay Soker, Chia Soo, Jessica M. Sun, Mays Talib, Shuhei Tara, Kang Ting, Rocky S. Tuan, Jolene E. Valentin, Dipen Vyas, Bo Wang, Jason A. Wertheim, Honghua Yu, Elie Zakhem, Elisabeth Zapatero-Solana, Nan Zhang, Yuanyuan Zhang

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fea9ec4b40c658faea5ab7d0501dfa4
https://doi.org/10.1016/b978-0-12-800548-4.01002-0

Targeting interleukin-6 as a treatment approach for peritoneal carcinomatosis.

Autor: Dadgar, Neda¹ (AUTHOR), Sherry, Christopher² (AUTHOR), Zimmerman, Jenna² (AUTHOR), Park, Hyun² (AUTHOR), Lewis, Catherine² (AUTHOR), Donnenberg, Albert² (AUTHOR), Zaidi, Ali H.² (AUTHOR), Fan, Yong² (AUTHOR), Xiao, Kunhong³ (AUTHOR), Bartlett, David² (AUTHOR), Donnenberg, Vera⁴ (AUTHOR), Wagner, Patrick L.² (AUTHOR) patrick.wagner@ahn.org

Publikováno v: Journal of Translational Medicine. 4/30/2024, Vol. 22 Issue 1, p1-18. 18p.