Zobrazeno 1 - 10
of 238
pro vyhledávání: '"Albena T. Dinkova-Kostova"'
Autor:
Chinmai Patibandla, Lidy van Aalten, Albena T. Dinkova-Kostova, Tadashi Honda, Antonio Cuadrado, Raquel Fernández-Ginés, Alison D. McNeilly, John D. Hayes, James Cantley, Calum Sutherland
Publikováno v:
Redox Biology, Vol 71, Iss , Pp 103117- (2024)
Accumulation of reactive oxygen species (i.e., oxidative stress) is a leading cause of beta cell dysfunction and apoptosis in diabetes. NRF2 (NF-E2 p45-related factor-2) regulates the adaptation to oxidative stress, and its activity is negatively reg
Externí odkaz:
https://doaj.org/article/174bdfaa05484649a9d4e82ff51fecbf
Autor:
Sharadha Dayalan Naidu, Aki Muramatsu, Ryota Saito, Soichiro Asami, Tadashi Honda, Tomonori Hosoya, Ken Itoh, Masayuki Yamamoto, Takafumi Suzuki, Albena T. Dinkova-Kostova
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/5dfbbe1b40ee41239edc4e542ee62be3
Autor:
Noemí Esteras, Thomas S. Blacker, Evgeny A. Zherebtsov, Olga A. Stelmashuk, Ying Zhang, W. Christian Wigley, Michael R. Duchen, Albena T. Dinkova-Kostova, Andrey Y. Abramov
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102672- (2023)
The transcription factor Nrf2 and its repressor Keap1 mediate cell stress adaptation by inducing expression of genes regulating cellular detoxification, antioxidant defence and energy metabolism. Energy production and antioxidant defence employ NADH
Externí odkaz:
https://doaj.org/article/4123d5a1ee434661a0e1f99bf4759861
Autor:
Christa P. Baker, Iain R. Phair, Alejandro J. Brenes, Abdelmadjid Atrih, Dylan G. Ryan, Roland Bruderer, Albena T. Dinkova-Kostova, Douglas J. Lamont, J. Simon C. Arthur, Andrew J.M. Howden
Publikováno v:
STAR Protocols, Vol 3, Iss 4, Pp 101725- (2022)
Summary: Here, we describe an optimized protocol to analyze murine bone-marrow-derived macrophages using label-free data-independent acquisition (DIA) proteomics. We provide a complete step-by-step protocol describing sample preparation utilizing the
Externí odkaz:
https://doaj.org/article/55dbb36cd7934934bcf60bd53c5f3bf4
Autor:
Kit‐Kay Mak, Zhang Shiming, Dr. Ola Epemolu, Prof. Dr. Albena T. Dinkova‐Kostova, Dr. Geoffrey Wells, Dr. Irina G. Gazaryan, Dr. Raghavendra Sakirolla, Prof. Dr. Zulkefeli Mohd, Prof. Dr. Mallikarjuna Rao Pichika
Publikováno v:
ChemistryOpen, Vol 11, Iss 10, Pp n/a-n/a (2022)
Abstract This is the first study investigating the nuclear factor (erythroid‐derived 2)‐like 2 (NRF2) activity of compounds containing a new scaffold, tetrahydrobenzo[b]thiophene. Eighteen compounds were synthesised and confirmed their NRF2 activ
Externí odkaz:
https://doaj.org/article/3b58c0e2150c48848d2a62f4f7dd5ec1
Autor:
Elena V. Knatko, Cecilia Castro, Maureen Higgins, Ying Zhang, Tadashi Honda, Colin J. Henderson, C. Roland Wolf, Julian L. Griffin, Albena T. Dinkova-Kostova
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Knatko et al. examined the importance of Nrf2 activity in the development of colorectal adenomas by performing genetic and pharmacological analyses. The authors found that Keap1 knockdown and Nrf2 activation impacted the metabolism of the non-tumoral
Externí odkaz:
https://doaj.org/article/7c780740b0f74743a3772c55d2dbaca7
Autor:
Yuta Horie, Takafumi Suzuki, Jin Inoue, Tatsuro Iso, Geoffrey Wells, Terry W. Moore, Tsunehiro Mizushima, Albena T. Dinkova-Kostova, Takuma Kasai, Takashi Kamei, Seizo Koshiba, Masayuki Yamamoto
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Using NMR spectroscopy, Horie, Suzuki, Inoue et al. show that the dissociation of Keap1 from Nrf2, or the Hinge-Latch mechanism, is triggered by Keap1-Nrf2 inhibitors and occurs during p62- mediated Nrf2 activation, but not by electrophilic Nrf2 indu
Externí odkaz:
https://doaj.org/article/b744783a8c5b4f278122faa72d2167f4
Publikováno v:
STAR Protocols, Vol 3, Iss 2, Pp 101265- (2022)
Summary: Pharmacologic inhibition of the protein-protein interaction (PPI) interface of the Keap1:Nrf2 complex, which leads to Nrf2 activation and cytoprotective gene expression, offers a promising strategy for disease prevention and treatment. To fa
Externí odkaz:
https://doaj.org/article/766063801b5e49d2a33f13f6b82b19ae
Autor:
Laura Casares, Rita Moreno, Kevin X. Ali, Maureen Higgins, Sharadha Dayalan Naidu, Graham Neill, Lena Cassin, Anders E. Kiib, Esben B. Svenningsen, Alberto Minassi, Tadashi Honda, Thomas B. Poulsen, Clotilde Wiel, Volkan I. Sayin, Albena T. Dinkova-Kostova, David Olagnier, Laureano de la Vega
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102291- (2022)
The transcription factor BACH1 is a potential therapeutic target for a variety of chronic conditions linked to oxidative stress and inflammation, as well as cancer metastasis. However, only a few BACH1 degraders/inhibitors have been described. BACH1
Externí odkaz:
https://doaj.org/article/1416ed819aa4406aaf232a9276b3919d
Autor:
Dylan G. Ryan, Elena V. Knatko, Alva M. Casey, Jens L. Hukelmann, Sharadha Dayalan Naidu, Alejandro J. Brenes, Thanapon Ekkunagul, Christa Baker, Maureen Higgins, Laura Tronci, Efterpi Nikitopolou, Tadashi Honda, Richard C. Hartley, Luke A.J. O’Neill, Christian Frezza, Angus I. Lamond, Andrey Y. Abramov, J. Simon C. Arthur, Doreen A. Cantrell, Michael P. Murphy, Albena T. Dinkova-Kostova
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103827- (2022)
Summary: To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH associated protein
Externí odkaz:
https://doaj.org/article/59b0d8bd2ed646e68bc099da31cf94d0