Zobrazeno 1 - 10
of 215
pro vyhledávání: '"Albee Messing"'
Publikováno v:
PLoS ONE, Vol 19, Iss 1 (2024)
Externí odkaz:
https://doaj.org/article/c8a7bb495d784a699e22801c2b343fb6
Autor:
Michelle M. Boyd, Suzanne J. Litscher, Laura L. Seitz, Albee Messing, Tracy L. Hagemann, Lara S. Collier
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-12 (2021)
Abstract Background Alexander disease (AxD) is a rare neurodegenerative disorder that is caused by dominant mutations in the gene encoding glial fibrillary acidic protein (GFAP), an intermediate filament that is primarily expressed by astrocytes. In
Externí odkaz:
https://doaj.org/article/1f287bbee59c40abaa415f56c48a0634
Publikováno v:
Cells, Vol 12, Iss 7, p 978 (2023)
Alexander disease (AxD) is caused by mutations in the gene for glial fibrillary acidic protein (GFAP), an intermediate filament expressed by astrocytes in the central nervous system. AxD-associated mutations cause GFAP aggregation and astrogliosis, a
Externí odkaz:
https://doaj.org/article/73cf2e06e61d4e96bc33ab64935f77de
Autor:
Albee Messing
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 11, Iss 1, Pp 1-4 (2019)
Abstract Background Alexander disease is caused by dominantly acting mutations in glial fibrillary acidic protein (GFAP), the major intermediate filament of astrocytes in the central nervous system. Main body In addition to the sequence variants that
Externí odkaz:
https://doaj.org/article/63ab39b70d614bd985004e5d90724aa3
Autor:
Michael Brenner, Albee Messing
Publikováno v:
ASN Neuro, Vol 13 (2021)
Expression of the GFAP gene has attracted considerable attention because its onset is a marker for astrocyte development, its upregulation is a marker for reactive gliosis, and its predominance in astrocytes provides a tool for their genetic manipula
Externí odkaz:
https://doaj.org/article/8519bc11f91b450797ecc740ec7d3f04
Autor:
Albee Messing, Michael Brenner
Publikováno v:
ASN Neuro, Vol 12 (2020)
Fifty years have passed since the discovery of glial fibrillary acidic protein (GFAP) by Lawrence Eng and colleagues. Now recognized as a member of the intermediate filament family of proteins, it has become a subject for study in fields as diverse a
Externí odkaz:
https://doaj.org/article/713dc578fb2b42eab692e802b2a95867
Autor:
Liqun Wang, Jing Xia, Jonathan Li, Tracy L. Hagemann, Jeffrey R. Jones, Ernest Fraenkel, David A. Weitz, Su-Chun Zhang, Albee Messing, Mel B. Feany
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Alexander disease is a rare neurodegeneration caused by mutations in a glial gene GFAP. Here, Wang and colleagues show in animal models of Alexander disease that GFAP mutant brain and cells have greater tissue and cellular stiffness and greater activ
Externí odkaz:
https://doaj.org/article/36c12df858ac434183e838e24dc960c5
Autor:
Jeffrey R. Jones, Linghai Kong, Michael G. Hanna, IV, Brianna Hoffman, Robert Krencik, Robert Bradley, Tracy Hagemann, Jeea Choi, Matthew Doers, Marina Dubovis, Mohammad Amin Sherafat, Anita Bhattacharyya, Christina Kendziorski, Anjon Audhya, Albee Messing, Su-Chun Zhang
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 947-958.e4 (2018)
Summary: How mutations in glial fibrillary acidic protein (GFAP) cause Alexander disease (AxD) remains elusive. We generated iPSCs from two AxD patients and corrected the GFAP mutations to examine the effects of mutant GFAP on human astrocytes. AxD a
Externí odkaz:
https://doaj.org/article/8661b3e265394aa380281091f516e8d2
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180694 (2017)
Alexander disease (AxD) is a neurodegenerative disease caused by heterozygous mutations in the GFAP gene, which encodes the major intermediate filament protein of astrocytes. This disease is characterized by the accumulation of cytoplasmic protein ag
Externí odkaz:
https://doaj.org/article/6904c79a477a4df28429d437f64e1c85
Autor:
Anna Duarri, Miguel Lopez de Heredia, Xavier Capdevila-Nortes, Margreet C. Ridder, Marisol Montolio, Tania López-Hernández, Ilja Boor, Chun-Fu Lien, Tracy Hagemann, Albee Messing, Dariusz C. Gorecki, Gert C. Scheper, Albert Martínez, Virginia Nunes, Marjo S. van der Knaap, Raúl Estévez
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 1, Pp 228-238 (2011)
Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare type of leukodystrophy, in the majority of cases caused by mutations in the MLC1 gene. MRI from MLC patients shows diffuse cerebral white matter signal abnormality and swellin
Externí odkaz:
https://doaj.org/article/ab7e770a271145778d5dd3d5e8bc9908