Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Albecka A"'
Autor:
Alex Kleinpeter, Donna L. Mallery, Nadine Renner, Anna Albecka, J. Ole Klarhof, Eric O. Freed, Leo C. James
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The HIV-1 capsid is composed of capsid (CA) protein hexamers and pentamers (capsomers) that contain a central pore hypothesised to regulate capsid assembly and facilitate nucleotide import early during post-infection. These pore functions ar
Externí odkaz:
https://doaj.org/article/146fe9a36e924c2a89d4ea1eeb9173fc
Autor:
Katherine U. Gaynor, Marina Vaysburd, Maximilian A. J. Harman, Anna Albecka, Phillip Jeffrey, Paul Beswick, Guido Papa, Liuhong Chen, Donna Mallery, Brian McGuinness, Katerine Van Rietschoten, Steven Stanway, Paul Brear, Aleksei Lulla, Katarzyna Ciazynska, Veronica T. Chang, Jo Sharp, Megan Neary, Helen Box, Jo Herriott, Edyta Kijak, Lee Tatham, Eleanor G. Bentley, Parul Sharma, Adam Kirby, Ximeng Han, James P. Stewart, Andrew Owen, John A. G. Briggs, Marko Hyvönen, Michael J. Skynner, Leo C. James
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract COVID-19 has stimulated the rapid development of new antibody and small molecule therapeutics to inhibit SARS-CoV-2 infection. Here we describe a third antiviral modality that combines the drug-like advantages of both. Bicycles are entropica
Externí odkaz:
https://doaj.org/article/83eee9acaa674188b99a7694be9c0c15
Akademický článek
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Autor:
Kleinpeter, Alex, Mallery, Donna L., Renner, Nadine, Albecka, Anna, Klarhof, J. Ole, Freed, Eric O., James, Leo C.
Publikováno v:
Nature Communications; 9/14/2024, Vol. 15 Issue 1, p1-15, 15p
Autor:
Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The HUSH complex plays a key role in controlling transcription of viruses and transposable elements. Here, the authors define the biochemical basis of HUSH assembly and show that the TASOR subunit contains a pseudo-PARP domain critical for HUSH-depen
Externí odkaz:
https://doaj.org/article/ec9909b7b0774e2691625135a2850ac1
Autor:
Javier Castillo-Olivares, David A. Wells, Matteo Ferrari, Andrew C. Y. Chan, Peter Smith, Angalee Nadesalingam, Minna Paloniemi, George W. Carnell, Luis Ohlendorf, Diego Cantoni, Martin Mayora-Neto, Phil Palmer, Paul Tonks, Nigel J. Temperton, David Peterhoff, Patrick Neckermann, Ralf Wagner, Rainer Doffinger, Sarah Kempster, Ashley D. Otter, Amanda Semper, Tim Brooks, Anna Albecka, Leo C. James, Mark Page, Wilhelm Schwaeble, Helen Baxendale, Jonathan L. Heeney
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Precision monitoring of antibody responses during the COVID-19 pandemic is increasingly important during large scale vaccine rollout and rise in prevalence of Severe Acute Respiratory Syndrome-related Coronavirus-2 (SARS-CoV-2) variants of concern (V
Externí odkaz:
https://doaj.org/article/83c33cb02bac4ce88d2084a406ccc680
Autor:
Jakub Luptak, Donna L. Mallery, Aminu S. Jahun, Anna Albecka, Dean Clift, Osaid Ather, Greg Slodkowicz, Ian Goodfellow, Leo C. James
Publikováno v:
Viruses, Vol 14, Iss 8, p 1610 (2022)
TRIM7 catalyzes the ubiquitination of multiple substrates with unrelated biological functions. This cross-reactivity is at odds with the specificity usually displayed by enzymes, including ubiquitin ligases. Here we show that TRIM7′s extreme substr
Externí odkaz:
https://doaj.org/article/de751fb30f1643d5ae43609ef27a7402
HIV-1 uses inositol hexakisphosphate (IP6) to build a metastable capsid capable of delivering its genome into the host nucleus. Here, we show that viruses that are unable to package IP6 lack capsid protection and are detected by innate immunity, resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28cda8fee089e63d981a0c2e62bc315d
https://www.repository.cam.ac.uk/handle/1810/347962
https://www.repository.cam.ac.uk/handle/1810/347962
Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion.
Autor:
Guido Papa, Donna L Mallery, Anna Albecka, Lawrence G Welch, Jérôme Cattin-Ortolá, Jakub Luptak, David Paul, Harvey T McMahon, Ian G Goodfellow, Andrew Carter, Sean Munro, Leo C James
Publikováno v:
PLoS Pathogens, Vol 17, Iss 1, p e1009246 (2021)
Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infects cells by binding to the host cell receptor ACE2 and undergoing virus-host membrane fusion. Fusion is triggered by the protease TMPRSS2, which processes the viral Spike (S) protein t
Externí odkaz:
https://doaj.org/article/e7f61576d1094208b86f915b6e68af06
Autor:
Nadine Renner, Alex Kleinpeter, Donna L. Mallery, Anna Albecka, K. M. Rifat Faysal, Till Böcking, Adolfo Saiardi, Eric O. Freed, Leo C. James
Publikováno v:
Nature Structural & Molecular Biology. 30:370-382