Influence of sex, age and diabetes on brain transcriptome and proteome modifications following cerebral ischemia

Autor: Laura Ramiro, Júlia Faura, Alba Simats, Paula García-Rodríguez, Feifei Ma, Luna Martín, Francesc Canals, Anna Rosell, Joan Montaner

Publikováno v: BMC Neuroscience, Vol 24, Iss 1, Pp 1-15 (2023)

Abstract Ischemic stroke is a major cause of death and disability worldwide. Translation into the clinical setting of neuroprotective agents showing promising results in pre-clinical studies has systematically failed. One possible explanation is that

Externí odkaz: https://doaj.org/article/f034745269f04a3195c5e741c91af626

T cells modulate the microglial response to brain ischemia

Autor: Corinne Benakis, Alba Simats, Sophie Tritschler, Steffanie Heindl, Simon Besson-Girard, Gemma Llovera, Kelsey Pinkham, Anna Kolz, Alessio Ricci, Fabian J Theis, Stefan Bittner, Özgün Gökce, Anneli Peters, Arthur Liesz

Publikováno v: eLife, Vol 11 (2022)

Neuroinflammation after stroke is characterized by the activation of resident microglia and the invasion of circulating leukocytes into the brain. Although lymphocytes infiltrate the brain in small number, they have been consistently demonstrated to

Externí odkaz: https://doaj.org/article/29761c34a6c0413cab34109057614566

Perspective Review of Myeloid Immune Cell Responses and Poststroke Immunosuppression

Autor: Wanqing Xie, Alba Simats, Yunlu Guo, Tingting Huang, Xiaoyu Sun, Weijie Chen, Yuxuan Lin, Xin Wang, Zhongmeng Lai, Weifeng Yu, Arthur Liesz, Peiying Li

Publikováno v: Stroke.

Ischemic stroke profoundly influences the peripheral immune system, which responds quickly to brain ischemia and participates in the evolution of poststroke neuroinflammation, while a period of systemic immunosuppression ensues. Poststroke immunosupp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab8f35decda805528395813f05e0f4a0
https://doi.org/10.1161/strokeaha.122.042075

Evaluation and Characterization of Post-Stroke Lung Damage in a Murine Model of Cerebral Ischemia

Autor: Júlia Faura, Laura Ramiro, Alba Simats, Feifei Ma, Anna Penalba, Teresa Gasull, Anna Rosell, Joan Montaner, Alejandro Bustamante

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8093
International Journal of Molecular Sciences
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname

After stroke and other brain injuries, there is a high incidence of respiratory complications such as pneumonia or acute lung injury. The molecular mechanisms that drive the brain-lung interaction post-stroke have not yet been elucidated. We performe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd127755b1173beda6d110e2862cc70a
https://hdl.handle.net/10668/21178

A Mouse Brain-based Multi-omics Integrative Approach Reveals Potential Blood Biomarkers for Ischemic Stroke

Autor: Alejandro Bustamante, Joan Montaner, Natalia Gill, Ricardo Gonzalo, Laura Ramiro, Anna Rosell, Teresa García-Berrocoso, Nuria Colomé, Anna Sabé, Alba Simats, Luna Martín, Anna Penalba, Francesc Canals, Alex Sánchez, Ferran Briansó

Publikováno v: Mol Cell Proteomics

Stroke remains a leading cause of death and disability worldwide. Despite continuous advances, the identification of key molecular signatures in the hyper-acute phase of ischemic stroke is still a primary interest for translational research on stroke

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36d5ee59d05066599dd4eff20f86c4b
https://doi.org/10.1074/mcp.ra120.002283