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Autor:
Eduardo Madrigal-Bujaidar, Germán Chamorro-Cevallos, Carvajal-Sandoval G, Pedro Zamudio-Cortes, Elías Parra-Hernández, Alba Martínez-Angoa
Publikováno v:
Birth Defects Research Part A: Clinical and Molecular Teratology. 76:731-738
BACKGROUND: Prenatal rat embryo exposure to retinoids induces severe malformations in various organs; the most active and teratogenic metabolite is all-trans-retinoic acid (atRA). The mechanisms of this embryopathy are only partly known. In the prese