Výsledky vyhledávání - "Alba Gigante"

Akademický článek

Leishmania infantum EndoG is an endo/exo-nuclease essential for parasite survival.

Autor: Eva Rico, Cristina Oliva, Kilian Jesús Gutierrez, Juan Fernando Alzate, Carlos Mario Genes, David Moreno, Elena Casanova, Alba Gigante, María-Jesús Pérez-Pérez, María-José Camarasa, Joachim Clos, Federico Gago, Antonio Jiménez-Ruiz

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e89526 (2014)

EndoG, a member of the DNA/RNA non-specific ββα-metal family of nucleases, has been demonstrated to be present in many organisms, including Trypanosomatids. This nuclease participates in the apoptotic program in these parasites by migrating from t

Externí odkaz: https://doaj.org/article/1af79e5702954df3b5e90f3e7c475a3d

Zobrazit plný text záznamu

Supplementary Figure 1 from The Thymidine Phosphorylase Inhibitor 5′-O-Tritylinosine (KIN59) Is an Antiangiogenic Multitarget Fibroblast Growth Factor-2 Antagonist

Autor: Marco Presta, Jan Balzarini, María-Jesús Pérez-Pérez, Ghislain Opdenakker, Elena Casanova, Alba Gigante, Beatrice Nico, Domenico Ribatti, Rebecca Sienaert, Antonella Bugatti, Mirella Belleri, Annelies Bronckaers, Sandra Liekens

PDF file - 252K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487e13485a8bb91aa76db38840ff203b
https://doi.org/10.1158/1535-7163.22498858

Zobrazit plný text záznamu

Supplementary Figure 2 from The Thymidine Phosphorylase Inhibitor 5′-O-Tritylinosine (KIN59) Is an Antiangiogenic Multitarget Fibroblast Growth Factor-2 Antagonist

PDF file - 238K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dca644a548590c1f484199b969c79d4
https://doi.org/10.1158/1535-7163.22498855

Zobrazit plný text záznamu

Supplementary Figure 3 from The Thymidine Phosphorylase Inhibitor 5′-O-Tritylinosine (KIN59) Is an Antiangiogenic Multitarget Fibroblast Growth Factor-2 Antagonist

PDF file - 62K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b14b9b8740041f524c25472f6e8216
https://doi.org/10.1158/1535-7163.22498852

Zobrazit plný text záznamu

A Supramolecular Stabilizer of the 14‐3‐3ζ/ERα Protein‐Protein Interaction with a Synergistic Mode of Action

Autor: Eline Sijbesma, Xiao‐Yu Hu, Christian Ottmann, Carsten Schmuck, Federico Gago, Pedro A. Sánchez-Murcia, Shirley K. Knauer, David Bier, Alba Gigante, Sandra Bäcker

Publikováno v: Angewandte Chemie (International Ed. in English)
Angewandte Chemie-International Edition, 59(13), 5284-5287. Wiley

We report on a stabilizer of the interaction between 14‐3‐3ζ and the Estrogen Receptor alpha (ERα). ERα is a driver in the majority of breast cancers and 14‐3‐3 proteins are negative regulators of this nuclear receptor, making the stabiliz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde41d87a6c6914e76c19062fc5d7c1f
http://europepmc.org/articles/PMC7155037

Zobrazit plný text záznamu

Multivalent ligands with tailor-made anion binding motif as stabilizers of protein–protein interactions

Autor: Jeroen Briels, Peter Bayer, Christian Ottmann, Lina Bartsch, Yasser B. Ruiz-Blanco, Maria Bartel, Javier Iglesias-Fernández, Christine Beuck, Elsa Sanchez-Garcia, Niklas Toetsch, Alba Gigante, Carsten Schmuck

Publikováno v: ChemBioChem, 20(23), 2921-2926. Wiley-VCH Verlag

Modulation of protein–protein interactions (PPIs) is essential for understanding and tuning biologically relevant processes. Although inhibitors for PPIs are widely used, the field still lacks the targeted design of stabilizers. Here, we report unn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::600f132cca64ba62a0f4ef61ac463103
https://doi.org/10.1002/cbic.201900288

Zobrazit plný text záznamu

Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Protein 1 Inhibitors

Autor: Leen Delang, Rhian Jones, Juan Reguera, María-Jesús Pérez-Pérez, Julia Moesslacher, Gerhard Pürstinger, Eric J. Snijder, Lak Shin Jeong, Johan Neyts, Alba Gigante, Kristina Kovacikova, Martijn J. van Hemert, Thierry Langer, Gerard J. P. van Westen, Marina Gorostiola González

Publikováno v: Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, 2021, 65 (7), ⟨10.1128/AAC.02566-20⟩
Antimicrobial Agents and Chemotherapy, 65(7). AMER SOC MICROBIOLOGY
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2021, 65 (7), ⟨10.1128/AAC.02566-20⟩
Antimicrobial Agents and Chemotherapy, 65(7). American Society for Microbiology
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Digital.CSIC. Repositorio Institucional del CSIC
instname

Chikungunya virus (CHIKV) nonstructural protein 1 (nsP1) harbors the methyltransferase (MTase) and guanylyltransferase (GTase) activities needed for viral RNA capping and represents a promising antiviral drug target. We compared the antiviral efficac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aa1598d3d938282630b217bae8c19d7
https://hal-amu.archives-ouvertes.fr/hal-03366195

Zobrazit plný text záznamu

A new class of supramolecular ligands stabilizes 14-3-3 protein-protein interactions by up to two orders of magnitude

Autor: Christian Ottmann, Alba Gigante, M. Bartel, J. Briels, Carsten Schmuck, Daniel Hoffmann, Jean-Noël Grad

Publikováno v: Chemical Communications, ChemComm, 55(1), 111-114. Royal Society of Chemistry

We report the first supramolecular stabilizers of the interaction between 14-3-3ζ and two of its effectors, Tau and C-Raf, which are involved in neurodegenerative diseases and proliferative signal transduction, respectively. These supramolecular lig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::321f62f63b901897c5431e36a82bd9e0
https://doi.org/10.1039/c8cc07946c

Zobrazit plný text záznamu

Locating Large, Flexible Ligands on Proteins

Autor: Ludwig Ohl, Jean-Noël Grad, Carsten Schmuck, Christoph Wilms, Christian Ottmann, Daniel Hoffmann, Jan Nikolaj Dybowski, Alba Gigante

Publikováno v: Journal of Chemical Information and Modeling, 58(2), 315-327. American Chemical Society

Many biologically important ligands of proteins are large, flexible, and in many cases charged molecules that bind to extended regions on the protein surface. It is infeasible or expensive to locate such ligands on proteins with standard methods such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698c047f2706bb7a5f9316b901eeae27
https://doi.org/10.1021/acs.jcim.7b00413

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání