Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Alba Galan"'
Autor:
Alba Galan, Arturo Papaluca, Ali Nejatie, Emad Matanes, Fouad Brahimi, Wenyong Tong, Ibrahim Yaseen Hachim, Amber Yasmeen, Euridice Carmona, Kathleen Oros Klein, Sonja Billes, Ahmed E. Dawod, Prasad Gawande, Anna Milik Jeter, Anne-Marie Mes-Masson, Celia M. T. Greenwood, Walter H. Gotlieb, H. Uri Saragovi
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundOvarian cancer (OC) is the deadliest gynecological cancer, often diagnosed at advanced stages. A fast and accurate diagnostic method for early-stage OC is needed. The tumor marker gangliosides, GD2 and GD3, exhibit properties that make them
Externí odkaz:
https://doaj.org/article/a20a7eb4b7de4c459fb30b314eba8359
Autor:
Alba Galan, Alejandro Seisdedos-Benzal, Beatrice Enrica Carletti, Setefilla Quiros, Eva Maria Martin, David Menor, Maria del Mar Granados
Publikováno v:
Veterinární Medicína, Vol 65, Iss 7, Pp 297-300 (2020)
The analysis of cerebrospinal fluid biomarkers provides a wide range of information about the neurological health of a patient. Lactate is a metabolic precursor necessary for brain gluconeogenesis. When oxidative impairment or mitochondrial damage is
Externí odkaz:
https://doaj.org/article/6f86ff98cdab4aca8a6db9fd019e8ff1
Autor:
Fouad Brahimi, Alba Galan, Sean Jmaeff, Pablo F. Barcelona, Nicolas De Jay, Kurt Dejgaard, Jason C. Young, Claudia L. Kleinman, David Y. Thomas, H. Uri Saragovi
Publikováno v:
iScience, Vol 23, Iss 9, Pp 101447- (2020)
Summary: Events at a receptor ectodomain affect the intracellular domain conformation, activating signal transduction (out-to-in conformational effects). We investigated the reverse direction (in-to-out) where the intracellular domain may impact on e
Externí odkaz:
https://doaj.org/article/a1ee55768c1b44989b14c88b23d6c507
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Neurotrophins (NTs) are a subset of the neurotrophic factor family. These growth factors were originally named based on the nerve growth functional assays used to identify them. NTs act as paracrine or autocrine factors for cells expressing NT recept
Externí odkaz:
https://doaj.org/article/66aef3b00c244a74aa0480849929cddb
Publikováno v:
PLoS ONE, Vol 13, Iss 6, p e0199079 (2018)
Many neurodegenerative retinal diseases are treated with monoclonal antibodies (mAb) delivered by invasive intravitreal injection (IVT). In Diabetic Retinopathy there is a scarcity of effective agents that can be delivered using non-invasive methods,
Externí odkaz:
https://doaj.org/article/95a01a4c4bff40f0bcdc3c3bf6b197a2
Autor:
Fouad Brahimi, Mario Maira, Pablo F Barcelona, Alba Galan, Tahar Aboulkassim, Katrina Teske, Mary-Louise Rogers, Lisa Bertram, Jing Wang, Masoud Yousefi, Robert Rush, Marc Fabian, Neil Cashman, H Uri Saragovi
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0162307 (2016)
Full length TrkC (TrkC-FL) is a receptor tyrosine kinase whose mRNA can be spliced to a truncated TrkC.T1 isoform lacking the kinase domain. Neurotrophin-3 (NT-3) activates TrkC-FL to maintain motor neuron health and function and TrkC.T1 to produce n
Externí odkaz:
https://doaj.org/article/9586ff7d786941bea985576cde95b154
Autor:
Alba Galan, Pauline Dergham, Pedro Escoll, Antonio de-la-Hera, Philippe M D'Onofrio, Mark M Magharious, Paulo D Koeberle, José María Frade, H Uri Saragovi
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101349 (2014)
Retinal ganglion cells (RGCs) are neurons that relay visual signals from the retina to the brain. The RGC cell bodies reside in the retina and their fibers form the optic nerve. Full transection (axotomy) of the optic nerve is an extra-retinal injury
Externí odkaz:
https://doaj.org/article/0813c48195554d0faa8ac438f040f18e
Autor:
Sairey Siegel, Stephanie Szobota, Alan C. Foster, Alba Galan, Marinko V. Sarunic, Fouad Brahimi, H. Uri Saragovi
Publikováno v:
Molecular Pharmacology. 100:491-501
The neurotrophin growth factors bind and activate two types of cell surface receptors: the tropomyosin receptor kinase (Trk) family and p75. TrkA, TrkB, and TrkC are bound preferentially by nerve growth factor, brain-derived neurotrophic factor, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbfba2523444945ec58acf9448bd81b
https://doi.org/10.1124/molpharm.121.000301
https://doi.org/10.1124/molpharm.121.000301
Autor:
H. Uri Saragovi, Alba Galan, Pablo F. Barcelona, Abubakr Mossa, Monica Velasquez Flores, Philippe Cammisotto, Lysanne Campeau, Samer Shamout
Publikováno v:
Diabetologia. 63:1932-1946
Although 80% of diabetic patients will suffer from voiding difficulties and urinary symptoms, defined as diabetic voiding dysfunction (DVD), therapeutic targets and treatment options are limited. We hypothesise that the blockade of the pro-nerve grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e99295b91750d0744edede37ff2277ab
https://doi.org/10.1007/s00125-020-05222-4
https://doi.org/10.1007/s00125-020-05222-4
Autor:
Fan Huang, Christopher E. Rudd, Mark E. Issa, Jie Su, Tomasz Rzymski, Marina Gimeno, Connie M. Krawczyk, Audrey Emond, Magdalena Masiejczyk, Qianyu Guo, Nahum Sonenberg, Alexandre Benoit, Milena Mazan, Ghanem Elias Ghanem, Dany Plourde, Brendan Cordeiro, Sonia V. del Rincón, Natascha Gagnon, David Dankort, Margarita Bartish, Jacek Faber, Yao Zhan, Mikhael Attias, Elie Khoury, Joelle Rémy-Sarrazin, Christophe Goncalves, Ivan Topisirovic, Alba Galan, H. Uri Saragovi, Ciriaco A. Piccirillo, Fabrice Journe, Wilson H. Miller, William Yang
Publikováno v:
J Clin Invest
Melanomas commonly undergo a phenotype switch, from a proliferative to an invasive state. Such tumor cell plasticity contributes to immunotherapy resistance; however, the mechanisms are not completely understood and thus are therapeutically unexploit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d845fe7afdd091bb817c6503a5a7834
https://doi.org/10.1172/jci140752
https://doi.org/10.1172/jci140752