Proteomic profiling of human plasma extracellular vesicles identifies PF4 and C1R as novel biomarker in sarcopenia

Autor: Paula Aparicio, David Navarrete‐Villanueva, Alba Gómez‐Cabello, Tresa López‐Royo, Enrique Santamaría, Joaquín Fernández‐Irigoyen, Karina Ausín, Manuel Arruebo, Victor Sebastian, Germán Vicente‐Rodríguez, Rosario Osta, Raquel Manzano

Publikováno v: Journal of Cachexia, Sarcopenia and Muscle, Vol 15, Iss 5, Pp 1883-1897 (2024)

Abstract Background Sarcopenia, the gradual and generalized loss of muscle mass and function with ageing, is one of the major health problems in older adults, given its high prevalence and substantial socioeconomic implications. Despite the extensive

Externí odkaz: https://doaj.org/article/d1f9518606374239b3f7f8bf3ae2919c

A systematic review of progranulin concentrations in biofluids in over 7,000 people—assessing the pathogenicity of GRN mutations and other influencing factors

Autor: Imogen J. Swift, Rosa Rademakers, NiCole Finch, Matt Baker, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Giacomina Rossi, Matthis Synofzik, Carlo Wilke, David Mengel, Caroline Graff, Leonel T. Takada, Raquel Sánchez-Valle, Anna Antonell, Daniela Galimberti, Chiara Fenoglio, Maria Serpente, Marina Arcaro, Stefanie Schreiber, Stefan Vielhaber, Philipp Arndt, Isabel Santana, Maria Rosario Almeida, Fermín Moreno, Myriam Barandiaran, Alazne Gabilondo, Johannes Stubert, Estrella Gómez-Tortosa, Pablo Agüero, M. José Sainz, Tomohito Gohda, Maki Murakoshi, Nozomu Kamei, Sarah Kittel-Schneider, Andreas Reif, Johannes Weigl, Jinlong Jian, Chuanju Liu, Ginette Serrero, Thomas Greither, Gerit Theil, Ebba Lohmann, Stefano Gazzina, Silvia Bagnoli, Giovanni Coppola, Amalia Bruni, Mirja Quante, Wieland Kiess, Andreas Hiemisch, Anne Jurkutat, Matthew S. Block, Aaron M. Carlson, Geir Bråthen, Sigrid Botne Sando, Gøril Rolfseng Grøntvedt, Camilla Lauridsen, Amanda Heslegrave, Carolin Heller, Emily Abel, Alba Gómez-Núñez, Roger Puey, Andrea Arighi, Enmanuela Rotondo, Lize C. Jiskoot, Lieke H. H. Meeter, João Durães, Marisa Lima, Miguel Tábuas-Pereira, João Lemos, Bradley Boeve, Ronald C. Petersen, Dennis W. Dickson, Neill R. Graff-Radford, Isabelle LeBer, Leila Sellami, Foudil Lamari, Fabienne Clot, Barbara Borroni, Valentina Cantoni, Jasmine Rivolta, Alberto Lleó, Juan Fortea, Daniel Alcolea, Ignacio Illán-Gala, Lucie Andres-Cerezo, Philip Van Damme, Jordi Clarimon, Petra Steinacker, Emily Feneberg, Markus Otto, Emma L. van der Ende, John C. van Swieten, Harro Seelaar, Henrik Zetterberg, Aitana Sogorb-Esteve, Jonathan D. Rohrer

Publikováno v: Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)

Abstract Background Pathogenic heterozygous mutations in the progranulin gene (GRN) are a key cause of frontotemporal dementia (FTD), leading to significantly reduced biofluid concentrations of the progranulin protein (PGRN). This has led to a number

Externí odkaz: https://doaj.org/article/1d7c751ac55c494a90e49ef788756561

Effects of a multicomponent training followed by a detraining period on metabolic syndrome profile of older adults

Autor: Jorge Subías-Perié, David Navarrete-Villanueva, Ángel Iván Fernández-García, Ana Moradell, Gabriel Lozano-Berges, Eva Gesteiro, Jorge Pérez-Gómez, Ignacio Ara, Alba Gómez-Cabello, Germán Vicente-Rodríguez, José Antonio Casajús

Publikováno v: Experimental Gerontology, Vol 186, Iss , Pp 112363- (2024)

Aims: The present study sought to analyze the effects of 6-month multicomponent training (MCT) combined with a 4-month detraining on metabolic syndrome (MetS) profile among older adults with decreased functional capacity. Methods: This quasi-experime

Externí odkaz: https://doaj.org/article/d466461021a141cd91e8dddde76215bf

Globe penetration during loco-regional anesthesia: prevalence and review of cases

Autor: Alba Gómez-Benlloch, Maximiliano Olivera, Jeroni Nadal, Gemma Julio, Javier Elizalde

Publikováno v: International Journal of Ophthalmology, Vol 15, Iss 10, Pp 1683-1690 (2022)

AIM: To describe prevalence and different clinical signs and management of cases with penetrating eye injuries during loco-regional anesthesia for ophthalmic surgery. METHODS: A retrospective review of clinical records was carried out, identifying ca

Externí odkaz: https://doaj.org/article/5c8e442d22284963b7df093db314a648

Características de la rehabilitación respiratoria: resultados de una auditoría nacional

Autor: Carlos Antonio Amado Diago, Ángel Julián Iglesias Merchán, Itxaso Sayago, Susana Chic, Alba Gómez, Pilar Cejudo

Publikováno v: Open Respiratory Archives, Vol 5, Iss 1, Pp 100221- (2023)

Externí odkaz: https://doaj.org/article/e3d624ed9bf74085bad525c504bea810