A novel mechanism for the prevention of transcription replication conflicts

Autor: Berta Canal, Alba Duch, Francesc Posas, Eulàlia de Nadal

Publikováno v: Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)

Transcription and replication complexes can coincide in space and time. Such coincidences may result in collisions that trigger genomic instability. The phosphorylation of Mrc1 by different signaling kinases is part of a general mechanism that serves

Externí odkaz: https://doaj.org/article/5a5ef5e6fc8741c19dacb92a0a7fb359

Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts

Autor: Francesc Posas, Gerhard Seisenbacher, Eulàlia de Nadal, María L. García-Rubio, Berta Canal, Alba Duch, Andrés Aguilera, Sonia Barroso

Publikováno v: Nature Communications
idUS. Depósito de Investigación de la Universidad de Sevilla
instname
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Recercat. Dipósit de la Recerca de Catalunya
Digital.CSIC. Repositorio Institucional del CSIC

Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have evolved strategies to prevent such conflicts. However, little is known regarding how cells cope with sudden increases of transc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8b68493fb4d1d09689ab7a9d4be3b6
http://europepmc.org/articles/PMC5785523

Coordinated control of replication and transcription by a SAPK protects genomic integrity

Autor: Eulàlia de Nadal, Gilad Yaakov, María L. García-Rubio, Irene Felipe-Abrio, Andrés Aguilera, Sonia Barroso, Francesc Posas, Alba Duch

Publikováno v: Nature; Vol 493
Digital.CSIC. Repositorio Institucional del CSIC
instname

Upon environmental changes or extracellular signals, cells are subjected to marked changes in gene expression 1,2. Dealing with high levels of transcription during replication is critical to prevent collisions between the transcription and replicatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9825c92102655d155747aa8f0516b46f
https://pubmed.ncbi.nlm.nih.gov/23473562

Time-dependent quantitative multicomponent control of the G₁-S network by the stress-activated protein kinase Hog1 upon osmostress

Autor: Miquel Àngel, Adrover, Zhike, Zi, Alba, Duch, Jörg, Schaber, Alberto, González-Novo, Javier, Jimenez, Mariona, Nadal-Ribelles, Josep, Clotet, Edda, Klipp, Francesc, Posas

Publikováno v: Science signaling. 4(192)

Control of cell cycle progression by stress-activated protein kinases (SAPKs) is essential for cell adaptation to extracellular stimuli. Exposure of yeast to hyperosmotic stress activates the SAPK Hog1, which delays cell cycle progression through G�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b04d3e644a8225cc92da36caf98c49a3
https://pubmed.ncbi.nlm.nih.gov/21954289

A Dbf4 mutant contributes to bypassing the Rad53-mediated block of origins of replication in response to genotoxic stress

Autor: James A. Wohlschlegel, Zophonías O. Jónsson, Gloria Palou, Roger Palou, Enrique Calvo, David G. Quintana, Alba Duch

Publikováno v: The Journal of biological chemistry. 286(4)

An intra-S phase checkpoint slows the rate of DNA replication in response to DNA damage and replication fork blocks in eukaryotic cells. In the budding yeast Saccharomyces cerevisiae, such down-regulation is achieved through the Rad53 kinase-dependen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae60b91ecbce7e5f3ca02f5545f7a012
https://pubmed.ncbi.nlm.nih.gov/21098477