Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Alba Dosil"'
Autor:
Alfonso Yubero, Aranzazu Barquín, Purificación Estévez, Bella Pajares, Luisa Sánchez, Piedad Reche, Jesús Alarcón, Julia Calzas, Lydia Gaba, José Fuentes, Ana Santaballa, Carmen Salvador, Luis Manso, Ana Herrero, Álvaro Taus, Raúl Márquez, Julia Madani, María Merino, Gloria Marquina, Victoria Casado, Manuel Constenla, María Gutiérrez, Alba Dosil, Antonio González-Martín
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-10 (2022)
Abstract Background: Rucaparib is a poly(ADP-ribose) polymerase inhibitor approved in Europe as maintenance therapy for recurrent platinum-sensitive (Pt-S) ovarian cancer (OC). The Rucaparib Access Programme (RAP) was designed to provide early access
Externí odkaz:
https://doaj.org/article/535064772afa48388b62acdd5418de2a
Autor:
Xavier Dolcet, Xavier Matias-Guiu, Antonio Llombart-Cussac, Joan Valls, Maria Santacana, Cristina Mirantes, Maria Alba Dosil, Mónica Domingo, Nuria Eritja
PDF - 1218K, Four ECCs (IK, AN3CA, MFE-296 and HEC-1A) were treated with Dovitinib (0.05-0.1-0.5-1-2.5 μmol/L) for 72 hours. Cells were stained with Hoechst. The graph on the right shows the percentage of cells displaying apoptotic nuclei in each co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030f3740c76466623d75c5fc88c8e809
https://doi.org/10.1158/1535-7163.22500991.v1
https://doi.org/10.1158/1535-7163.22500991.v1
Autor:
Xavier Dolcet, Xavier Matias-Guiu, Antonio Llombart-Cussac, Joan Valls, Maria Santacana, Cristina Mirantes, Maria Alba Dosil, Mónica Domingo, Nuria Eritja
PDF - 51K, Analysis of Variance tables. Degrees of freedom (Df), sum of squares (SS), mean sum of squares (Mean SS) and corresponding F statistic and p-value are shown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3aed51bcafebaae7f960f162e8a6df
https://doi.org/10.1158/1535-7163.22500970.v1
https://doi.org/10.1158/1535-7163.22500970.v1
Autor:
Xavier Dolcet, Xavier Matias-Guiu, Antonio Llombart-Cussac, Joan Valls, Maria Santacana, Cristina Mirantes, Maria Alba Dosil, Mónica Domingo, Nuria Eritja
Mutations in fibroblast growth factor receptor 2 (FGFR2) have been recently described as a molecular-specific feature in endometrial carcinomas and the presence of activated FGFR2 mutations is associated with poor prognosis. For that reason, inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478f14ae87df1a1e298157b8d794de4f
https://doi.org/10.1158/1535-7163.c.6536650.v1
https://doi.org/10.1158/1535-7163.c.6536650.v1
Autor:
Xavier Dolcet, Xavier Matias-Guiu, Antonio Llombart-Cussac, Joan Valls, Maria Santacana, Cristina Mirantes, Maria Alba Dosil, Mónica Domingo, Nuria Eritja
PDF - 66K, Legends for Supplementary Figures 1 through 5.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9bb9a13d4f1903e204d5c1bdef4b0e9
https://doi.org/10.1158/1535-7163.22500976.v1
https://doi.org/10.1158/1535-7163.22500976.v1
Autor:
Xavier Dolcet, Xavier Matias-Guiu, Antonio Llombart-Cussac, Joan Valls, Maria Santacana, Cristina Mirantes, Maria Alba Dosil, Mónica Domingo, Nuria Eritja
PDF - 27K, Representative graphs mean of cell survival (in percentages) for each combination of Dovitinib and ICI. Confidence intervals as estimated from the linear models are shown. Experiments were performed, at least, 3 times on 3 independent days
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac12d9031fb360035c67d63e91b207f3
https://doi.org/10.1158/1535-7163.22500985.v1
https://doi.org/10.1158/1535-7163.22500985.v1
Autor:
Cristina Mirantes, Núria Eritja, Maria Alba Dosil, Maria Santacana, Judit Pallares, Sónia Gatius, Laura Bergadà, Oscar Maiques, Xavier Matias-Guiu, Xavier Dolcet
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 3, Pp 710-720 (2013)
SUMMARY PTEN is one of the most frequently mutated tumor suppressor genes in human cancers. The role of PTEN in carcinogenesis has been validated by knockout mouse models. PTEN heterozygous mice develop neoplasms in multiple organs. Unfortunately, th
Externí odkaz:
https://doaj.org/article/ef731cf3c44f4c4d94d4002ea39b22b3
Autor:
Ana Velasco, Marta Vaquero, Cristina Megino, Sonia Gatius, Isidre Felip, Raúl Navaridas, Cristina Mirantes, Xavier Dolcet, Maria Alba Dosil, Carla Barceló, Izaskun Urdanibia, Anna Macià, Jordi Tarragona, Maria Santacana, Xavier Matias-Guiu, Carme Piñol, Nuria Eritja, Mónica Domingo, Oscar Maiques
Publikováno v:
The Journal of Pathology. 247:72-85
Many human cancers present Phosphatase and tensin homolog (PTEN) deficiency and between 20 and 30% of colorectal tumors show PTEN loss. The transcription factor, E2 promoter binding factor 1 (E2F-1), exhibits tumor promoter or suppressive functions d
Autor:
Cristina Mirantes, Sonia Gatius, Eloi Garí, Cristian Pablo Moiola, Xavier Matias-Guiu, Raúl Navaridas, Mario Encinas, Nuria Eritja, Eva Colas, Isidre Felip, Maria Alba Dosil, J.A. Schoenenberger, Xavier Dolcet, Maria Santacana
Publikováno v:
The Journal of Pathology. 242:152-164
PTEN is one of the most frequently mutated genes in human cancers. The frequency of PTEN alterations is particularly high in endometrial carcinomas. Loss of PTEN leads to dysregulation of cell division, and promotes the accumulation of cell cycle com
Autor:
Xavier Dolcet, Cristina Mirantes, Sonia Gatius, Jian Yang, Felip Vilardell, Maria Alba Dosil, David Hills, Maria Santacana, Nuria Eritja, Xavier Matias-Guiu, Alexander Medvinsky
Publikováno v:
Medvinsky, A, Hills, D, Mirantes, C & Dosil, M A 2016, ' Deletion of Pten of CD45-expressing cells leads to development of T-cell lymphoblastic lymphoma but not myeloid malignancies ', Blood, vol. 127, no. 5, pp. 1907-1911 . https://doi.org/10.1182/blood-2015-09-669036
Since its discovery in the late 1990s, Pten has turned out to be one of the most important tumor suppressor genes. Pten loss results in increased activation of the phosphatidylinositol 3-kinase/Akt signaling pathway, which is associated with increase